Estimated Pulse Wave Velocity Is Associated With All-Cause Mortality During 8.5 Years Follow-up in Patients Undergoing Elective Coronary Angiography
Background Estimated pulse wave velocity (ePWV) calculated by equations using age and blood pressure has been suggested as a new marker of mortality and cardiovascular risk. However, the prognostic potential of ePWV during long-term follow-up in patients with symptoms of stable angina remains unknown. Methods and Results In this study, ePWV was calculated in 25 066 patients without diabetes, previous myocardial infarction (MI), stroke, heart failure, or valvular disease (mean age 63.7±10.5 years, 58% male) with stable angina pectoris undergoing elective coronary angiography during 2003 to 2016. Multivariable Cox models were used to assess the association with incident all-cause mortality, MI, and stroke. Discrimination was assessed using Harrell´s C-index. During a median follow-up period of 8.5 years (interquartile range 5.5-11.3 years), 779 strokes, 1233 MIs, and 4112 deaths were recorded. ePWV was associated with all-cause mortality (hazard ratio [HR] per 1 m/s, 1.13; 95% CI, 1.05-1.21) and MI (HR per 1 m/s 1.23, 95% CI, 1.09-1.39) after adjusting for age, systolic blood pressure, body mass index, smoking, estimated glomerular filtration rate, Charlson Comorbidity Index score, antihypertensive treatment, statins, aspirin, and number of diseased coronary arteries. Compared with traditional risk factors, the adjusted model with ePWV was associated with a minor but likely not clinically relevant increase in discrimination for mortality, 76.63% with ePWV versus 76.56% without ePWV, P<0.05. Conclusions In patients with stable angina pectoris, ePWV was associated with all-cause mortality and MI beyond traditional risk factors. However, the added prediction of mortality was not improved to a clinically relevant extent.
| Errataetall: |
CommentIn: J Am Heart Assoc. 2022 May 17;11(10):e025830. - PMID 35535609 |
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| Medienart: |
E-Artikel |
| Erscheinungsjahr: |
2022 |
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| Erschienen: |
2022 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:11 |
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| Enthalten in: |
Journal of the American Heart Association - 11(2022), 10 vom: 17. Mai, Seite e025173 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Laugesen, Esben [VerfasserIn] |
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| Links: |
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| Themen: |
All‐cause mortality |
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| Anmerkungen: |
Date Completed 19.05.2022 Date Revised 25.07.2022 published: Print-Electronic CommentIn: J Am Heart Assoc. 2022 May 17;11(10):e025830. - PMID 35535609 Citation Status MEDLINE |
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| doi: |
10.1161/JAHA.121.025173 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM340639253 |
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| 245 | 1 | 0 | |a Estimated Pulse Wave Velocity Is Associated With All-Cause Mortality During 8.5 Years Follow-up in Patients Undergoing Elective Coronary Angiography |
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| 500 | |a Date Revised 25.07.2022 | ||
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| 500 | |a CommentIn: J Am Heart Assoc. 2022 May 17;11(10):e025830. - PMID 35535609 | ||
| 500 | |a Citation Status MEDLINE | ||
| 520 | |a Background Estimated pulse wave velocity (ePWV) calculated by equations using age and blood pressure has been suggested as a new marker of mortality and cardiovascular risk. However, the prognostic potential of ePWV during long-term follow-up in patients with symptoms of stable angina remains unknown. Methods and Results In this study, ePWV was calculated in 25 066 patients without diabetes, previous myocardial infarction (MI), stroke, heart failure, or valvular disease (mean age 63.7±10.5 years, 58% male) with stable angina pectoris undergoing elective coronary angiography during 2003 to 2016. Multivariable Cox models were used to assess the association with incident all-cause mortality, MI, and stroke. Discrimination was assessed using Harrell´s C-index. During a median follow-up period of 8.5 years (interquartile range 5.5-11.3 years), 779 strokes, 1233 MIs, and 4112 deaths were recorded. ePWV was associated with all-cause mortality (hazard ratio [HR] per 1 m/s, 1.13; 95% CI, 1.05-1.21) and MI (HR per 1 m/s 1.23, 95% CI, 1.09-1.39) after adjusting for age, systolic blood pressure, body mass index, smoking, estimated glomerular filtration rate, Charlson Comorbidity Index score, antihypertensive treatment, statins, aspirin, and number of diseased coronary arteries. Compared with traditional risk factors, the adjusted model with ePWV was associated with a minor but likely not clinically relevant increase in discrimination for mortality, 76.63% with ePWV versus 76.56% without ePWV, P<0.05. Conclusions In patients with stable angina pectoris, ePWV was associated with all-cause mortality and MI beyond traditional risk factors. However, the added prediction of mortality was not improved to a clinically relevant extent | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a Research Support, Non-U.S. Gov't | |
| 650 | 4 | |a all‐cause mortality | |
| 650 | 4 | |a blood pressure measurement | |
| 650 | 4 | |a estimated pulse wave velocity | |
| 650 | 4 | |a myocardial infarction | |
| 650 | 4 | |a stroke | |
| 700 | 1 | |a Olesen, Kevin K W |e verfasserin |4 aut | |
| 700 | 1 | |a Peters, Christian Daugaard |e verfasserin |4 aut | |
| 700 | 1 | |a Buus, Niels Henrik |e verfasserin |4 aut | |
| 700 | 1 | |a Maeng, Michael |e verfasserin |4 aut | |
| 700 | 1 | |a Botker, Hans Erik |e verfasserin |4 aut | |
| 700 | 1 | |a Poulsen, Per L |e verfasserin |4 aut | |
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