Clinical and Histological Prognostic Factors of Recurrence and Malignant Transformation in a Large Series of Oral Potentially Malignant Disorders
Copyright © 2022 Lorini, Tomasoni, Gurizzan, Magri, Facchetti, Battocchio, Romani, Ravanelli, Oberti, Bozzola, Bardellini, Paderno, Mattavelli, Lombardi, Grammatica, Deganello, Facchetti, Calza, Majorana, Piazza and Bossi..
Background: Oral potentially malignant disorders (OPMDs) represent a heterogeneous set of different histological lesions, characterized by the capacity to transform in oral squamous cell carcinoma (OSCC). Despite optimal surgical treatment, approximately 20%-30% of OPMDs may evolve into OSCC. No clear clinical/histological factors are able to identify OPMDs at higher risk of malignant transformation.
Materials and Methods: We considered surgically treated patients with a diagnosis of OPMDs, enrolled from 1996 to 2019 at ASST Spedali Civili of Brescia without a diagnosis of OSCC within the previous 2 years. Clinical and histological characteristics were recorded. Outcomes of interest were recurrence-free survival (RFS), defined as the time from surgery for primary OPMD to any relapse of OPMD or malignant transformation, whichever occurred first, and carcinoma-free survival (CFS), defined as the time from surgery for OPMD to malignant transformation.
Results: We retrospectively reviewed 106 OPMDs cases. Median age at first diagnosis was 64 years old (IQR = 18.75); female patients comprise 51.9% of the cases. During a median follow-up of 30.5 months (IQR = 44), in 23.5% of patients, malignant transformation occurred. RFS at 1, 5, and 10 years was 92.4%, 60.9%, and 43.2%, respectively. Female sex and history of previous OSCC were independent risk factors for RFS. CFS at 1, 5, and 10 years of follow-up was 97.1%, 75.9%, and 64.4%, respectively. Previous OSCC was an independent risk factor for CFS.
Conclusions: In this large series of OPMDs, only previous diagnosis of OSCC was a prognostic factor for further OSCC occurrence. Given the lack of additional clinical/pathological prognostic factors, we advocate further studies into molecular characterization of OPMDs to better stratify the risk of malignant transformation.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2022 |
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| Erschienen: |
2022 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:12 |
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| Enthalten in: |
Frontiers in oncology - 12(2022) vom: 22., Seite 886404 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Lorini, Luigi [VerfasserIn] |
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| Links: |
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| Anmerkungen: |
Date Revised 16.07.2022 published: Electronic-eCollection Citation Status PubMed-not-MEDLINE |
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| doi: |
10.3389/fonc.2022.886404 |
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| Förderinstitution / Projekttitel: |
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NLM340588268 |
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| 100 | 1 | |a Lorini, Luigi |e verfasserin |4 aut | |
| 245 | 1 | 0 | |a Clinical and Histological Prognostic Factors of Recurrence and Malignant Transformation in a Large Series of Oral Potentially Malignant Disorders |
| 264 | 1 | |c 2022 | |
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| 500 | |a Citation Status PubMed-not-MEDLINE | ||
| 520 | |a Copyright © 2022 Lorini, Tomasoni, Gurizzan, Magri, Facchetti, Battocchio, Romani, Ravanelli, Oberti, Bozzola, Bardellini, Paderno, Mattavelli, Lombardi, Grammatica, Deganello, Facchetti, Calza, Majorana, Piazza and Bossi. | ||
| 520 | |a Background: Oral potentially malignant disorders (OPMDs) represent a heterogeneous set of different histological lesions, characterized by the capacity to transform in oral squamous cell carcinoma (OSCC). Despite optimal surgical treatment, approximately 20%-30% of OPMDs may evolve into OSCC. No clear clinical/histological factors are able to identify OPMDs at higher risk of malignant transformation | ||
| 520 | |a Materials and Methods: We considered surgically treated patients with a diagnosis of OPMDs, enrolled from 1996 to 2019 at ASST Spedali Civili of Brescia without a diagnosis of OSCC within the previous 2 years. Clinical and histological characteristics were recorded. Outcomes of interest were recurrence-free survival (RFS), defined as the time from surgery for primary OPMD to any relapse of OPMD or malignant transformation, whichever occurred first, and carcinoma-free survival (CFS), defined as the time from surgery for OPMD to malignant transformation | ||
| 520 | |a Results: We retrospectively reviewed 106 OPMDs cases. Median age at first diagnosis was 64 years old (IQR = 18.75); female patients comprise 51.9% of the cases. During a median follow-up of 30.5 months (IQR = 44), in 23.5% of patients, malignant transformation occurred. RFS at 1, 5, and 10 years was 92.4%, 60.9%, and 43.2%, respectively. Female sex and history of previous OSCC were independent risk factors for RFS. CFS at 1, 5, and 10 years of follow-up was 97.1%, 75.9%, and 64.4%, respectively. Previous OSCC was an independent risk factor for CFS | ||
| 520 | |a Conclusions: In this large series of OPMDs, only previous diagnosis of OSCC was a prognostic factor for further OSCC occurrence. Given the lack of additional clinical/pathological prognostic factors, we advocate further studies into molecular characterization of OPMDs to better stratify the risk of malignant transformation | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a head and neck squamous cell carcinoma (HNSCC) | |
| 650 | 4 | |a oral carcinoma risk factors | |
| 650 | 4 | |a oral potentially malignant disease | |
| 650 | 4 | |a oral squamous cell carcinoma (OSCC) | |
| 650 | 4 | |a prevention of malignant transformation | |
| 700 | 1 | |a Tomasoni, Michele |e verfasserin |4 aut | |
| 700 | 1 | |a Gurizzan, Cristina |e verfasserin |4 aut | |
| 700 | 1 | |a Magri, Chiara |e verfasserin |4 aut | |
| 700 | 1 | |a Facchetti, Mattia |e verfasserin |4 aut | |
| 700 | 1 | |a Battocchio, Simonetta |e verfasserin |4 aut | |
| 700 | 1 | |a Romani, Chiara |e verfasserin |4 aut | |
| 700 | 1 | |a Ravanelli, Marco |e verfasserin |4 aut | |
| 700 | 1 | |a Oberti, Arianna |e verfasserin |4 aut | |
| 700 | 1 | |a Bozzola, Anna |e verfasserin |4 aut | |
| 700 | 1 | |a Bardellini, Elena |e verfasserin |4 aut | |
| 700 | 1 | |a Paderno, Alberto |e verfasserin |4 aut | |
| 700 | 1 | |a Mattavelli, Davide |e verfasserin |4 aut | |
| 700 | 1 | |a Lombardi, Davide |e verfasserin |4 aut | |
| 700 | 1 | |a Grammatica, Alberto |e verfasserin |4 aut | |
| 700 | 1 | |a Deganello, Alberto |e verfasserin |4 aut | |
| 700 | 1 | |a Facchetti, Fabio |e verfasserin |4 aut | |
| 700 | 1 | |a Calza, Stefano |e verfasserin |4 aut | |
| 700 | 1 | |a Majorana, Alessandra |e verfasserin |4 aut | |
| 700 | 1 | |a Piazza, Cesare |e verfasserin |4 aut | |
| 700 | 1 | |a Bossi, Paolo |e verfasserin |4 aut | |
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