Peak plasma concentration of total and free bupivacaine after erector spinae plane and pectointercostal fascial plane blocks
© 2022. Canadian Anesthesiologists' Society..
PURPOSE: Erector spinae plane blocks (ESPB) and pectointercostal fascial (PIFB) plane blocks are novel interfascial blocks for which local anesthetic (LA) doses and concentrations necessary to achieve safe and effective analgesia are unknown. The goal of this prospective observational study was to provide the timing (Tmax) and concentration (Cmax) of maximum total and free plasma bupivacaine after ESPB in breast surgery and after PIFB in cardiac surgery patients.
METHODS: Erector spinae plane blocks or PIFBs (18 patients per block; total, 36 patients) were performed with 2 mg⋅kg-1 of bupivacaine with epinephrine 5 μg⋅mL-1. Our principal outcomes were the mean or median Cmax of total and free plasma bupivacaine measured 10, 20, 30, 45, 60, 90, 180, and 240 min after LA injection using liquid chromatography with tandem mass spectrometry.
RESULTS: For ESPB, the mean (standard deviation [SD]) total bupivacaine Cmax was 0.37 (0.12) μg⋅mL-1 (range, 0.19 to 0.64), and the median [interquartile range (IQR)] Tmax was 30 [50] min (range, 10-180). For ESPB, the mean (SD) free bupivacaine Cmax was 0.015 (0.017) μg⋅mL-1 (range, 0.003-0.067), and the median [IQR] Tmax was 30 [20] min (range, 10-120). After PIFB, mean plasma concentrations plateaued at 60-240 min. For PIFB, the mean (SD) total bupivacaine Cmax was 0.32 (0.21) μg⋅mL-1 (range, 0.14-0.95), with a median [IQR] Tmax of 120 [150] min (range, 30-240). For PIFB, the mean (SD) free bupivacaine Cmax was 0.019 (0.010) μg⋅mL-1 (range, 0.005-0.048), and the median [IQR] Tmax was 180 [120] min (range, 30-240). For both ESPB and PIFB, we observed no correlations between pharmacokinetic and demographic parameters.
CONCLUSION: Total and free bupivacaine Cmax observed after ESPB and PIFB with 2 mg⋅kg-1 of bupivacaine with epinephrine 5 μg⋅mL-1 were five to twenty times lower than levels considered toxic in the literature.
| Errataetall: |
CommentIn: Expert Opin Drug Metab Toxicol. 2022 Sep;18(9):537-539. - PMID 36084290 |
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| Medienart: |
E-Artikel |
| Erscheinungsjahr: |
2022 |
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| Erschienen: |
2022 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:69 |
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| Enthalten in: |
Canadian journal of anaesthesia = Journal canadien d'anesthesie - 69(2022), 9 vom: 06. Sept., Seite 1151-1159 |
| Sprache: |
Englisch |
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| Weiterer Titel: |
Concentrations plasmatiques maximales de bupivacaïne totale et libre après des blocs des muscles érecteurs du rachis et des plans fasciaux pecto-intercostaux |
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| Beteiligte Personen: |
Maximos, Sarah [VerfasserIn] |
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| Links: |
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| Themen: |
Analgesia |
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| Anmerkungen: |
Date Completed 16.09.2022 Date Revised 26.12.2023 published: Print-Electronic CommentIn: Expert Opin Drug Metab Toxicol. 2022 Sep;18(9):537-539. - PMID 36084290 Citation Status MEDLINE |
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| doi: |
10.1007/s12630-022-02260-x |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| 100 | 1 | |a Maximos, Sarah |e verfasserin |4 aut | |
| 245 | 1 | 0 | |a Peak plasma concentration of total and free bupivacaine after erector spinae plane and pectointercostal fascial plane blocks |
| 246 | 3 | 3 | |a Concentrations plasmatiques maximales de bupivacaïne totale et libre après des blocs des muscles érecteurs du rachis et des plans fasciaux pecto-intercostaux |
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| 500 | |a Date Completed 16.09.2022 | ||
| 500 | |a Date Revised 26.12.2023 | ||
| 500 | |a published: Print-Electronic | ||
| 500 | |a CommentIn: Expert Opin Drug Metab Toxicol. 2022 Sep;18(9):537-539. - PMID 36084290 | ||
| 500 | |a Citation Status MEDLINE | ||
| 520 | |a © 2022. Canadian Anesthesiologists' Society. | ||
| 520 | |a PURPOSE: Erector spinae plane blocks (ESPB) and pectointercostal fascial (PIFB) plane blocks are novel interfascial blocks for which local anesthetic (LA) doses and concentrations necessary to achieve safe and effective analgesia are unknown. The goal of this prospective observational study was to provide the timing (Tmax) and concentration (Cmax) of maximum total and free plasma bupivacaine after ESPB in breast surgery and after PIFB in cardiac surgery patients | ||
| 520 | |a METHODS: Erector spinae plane blocks or PIFBs (18 patients per block; total, 36 patients) were performed with 2 mg⋅kg-1 of bupivacaine with epinephrine 5 μg⋅mL-1. Our principal outcomes were the mean or median Cmax of total and free plasma bupivacaine measured 10, 20, 30, 45, 60, 90, 180, and 240 min after LA injection using liquid chromatography with tandem mass spectrometry | ||
| 520 | |a RESULTS: For ESPB, the mean (standard deviation [SD]) total bupivacaine Cmax was 0.37 (0.12) μg⋅mL-1 (range, 0.19 to 0.64), and the median [interquartile range (IQR)] Tmax was 30 [50] min (range, 10-180). For ESPB, the mean (SD) free bupivacaine Cmax was 0.015 (0.017) μg⋅mL-1 (range, 0.003-0.067), and the median [IQR] Tmax was 30 [20] min (range, 10-120). After PIFB, mean plasma concentrations plateaued at 60-240 min. For PIFB, the mean (SD) total bupivacaine Cmax was 0.32 (0.21) μg⋅mL-1 (range, 0.14-0.95), with a median [IQR] Tmax of 120 [150] min (range, 30-240). For PIFB, the mean (SD) free bupivacaine Cmax was 0.019 (0.010) μg⋅mL-1 (range, 0.005-0.048), and the median [IQR] Tmax was 180 [120] min (range, 30-240). For both ESPB and PIFB, we observed no correlations between pharmacokinetic and demographic parameters | ||
| 520 | |a CONCLUSION: Total and free bupivacaine Cmax observed after ESPB and PIFB with 2 mg⋅kg-1 of bupivacaine with epinephrine 5 μg⋅mL-1 were five to twenty times lower than levels considered toxic in the literature | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a Observational Study | |
| 650 | 4 | |a Analgesia | |
| 650 | 4 | |a block | |
| 650 | 4 | |a bupivacaine | |
| 650 | 4 | |a erector spinae | |
| 650 | 4 | |a pectointercostal | |
| 650 | 4 | |a pharmacokinetics | |
| 650 | 7 | |a Anesthetics, Local |2 NLM | |
| 650 | 7 | |a Bupivacaine |2 NLM | |
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| 700 | 1 | |a Vaillancourt-Jean, Éric |e verfasserin |4 aut | |
| 700 | 1 | |a Mouksassi, Samer |e verfasserin |4 aut | |
| 700 | 1 | |a De Cassai, Alessandro |e verfasserin |4 aut | |
| 700 | 1 | |a Ayoub, Sophie |e verfasserin |4 aut | |
| 700 | 1 | |a Ruel, Monique |e verfasserin |4 aut | |
| 700 | 1 | |a Desroches, Julie |e verfasserin |4 aut | |
| 700 | 1 | |a Hétu, Pierre-Oliver |e verfasserin |4 aut | |
| 700 | 1 | |a Moore, Alex |e verfasserin |4 aut | |
| 700 | 1 | |a Williams, Stephan |e verfasserin |4 aut | |
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