Prognostic impact of renal function trajectories in patients with STEMI and kidney dysfunction undergoing primary percutaneous coronary intervention : An analysis of ten years all-comers registry
Copyright © 2022 Hellenic Society of Cardiology. Published by Elsevier B.V. All rights reserved..
BACKGROUND: Renal dysfunction in patients with ST-elevation myocardial infarction (STEMI) undergoing primary percutaneous coronary intervention (pPCI) indicates a poor long-term prognosis. However, the prognostic value of the improvement or stabilisation of renal function during follow-up has not yet been assessed. This study aimed to investigate the long-term predictive impact of the improvement or stabilisation of renal function after one year of follow-up in patients with STEMI undergoing pPCI with renal dysfunction at discharge.
METHODS: This prospective, single-centre cohort study included 2170 consecutive patients with STEMI who underwent pPCI. The glomerular filtration rate (GFR) was determined at hospital discharge and one-year follow-up. The median clinical follow-up was 72 months.
RESULTS: Among the 2004 patients, 393 (19.6%) had a GFR <60 ml/min, and 1611 (80.4%) had a GFR ≥ 60 ml/min at discharge. Among patients with GFR <60 ml/min, data at one-year follow-up were available for 342. Of these patients, 127 (32%) showed improvement in renal function (defined as improvement in the Kidney Disease Improving Global Outcomes (KDIGO) chronic kidney disease (CKD) classification), 47 (12%) showed worsening of renal function (defined as worsening of the KDIGO CKD classification), and 168 (43%) showed no category changes. Improvement or stabilisation of GFR at one year of follow-up was associated with a reduction of major adverse cardiovascular events (MACE) [HR 0.51, 95% CI: 0.35-0.75, p = 0.001] and all-cause mortality [HR 0.54, 95% CI: 0.34-0.84, p = 0.007] during follow-up.
CONCLUSIONS: The improvement or stabilisation of renal function at one-year follow-up in patients with STEMI and renal dysfunction is associated with a better long-term prognosis.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2022 |
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| Erschienen: |
2022 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:66 |
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| Enthalten in: |
Hellenic journal of cardiology : HJC = Hellenike kardiologike epitheorese - 66(2022) vom: 01. Juli, Seite 1-10 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Tasende Rey, Pablo [VerfasserIn] |
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| Links: |
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| Themen: |
Improvement or stabilisation of renal function |
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| Anmerkungen: |
Date Completed 16.08.2022 Date Revised 16.08.2022 published: Print-Electronic Citation Status MEDLINE |
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| doi: |
10.1016/j.hjc.2022.04.007 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM340418869 |
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| 100 | 1 | |a Tasende Rey, Pablo |e verfasserin |4 aut | |
| 245 | 1 | 0 | |a Prognostic impact of renal function trajectories in patients with STEMI and kidney dysfunction undergoing primary percutaneous coronary intervention |b An analysis of ten years all-comers registry |
| 264 | 1 | |c 2022 | |
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| 500 | |a Date Completed 16.08.2022 | ||
| 500 | |a Date Revised 16.08.2022 | ||
| 500 | |a published: Print-Electronic | ||
| 500 | |a Citation Status MEDLINE | ||
| 520 | |a Copyright © 2022 Hellenic Society of Cardiology. Published by Elsevier B.V. All rights reserved. | ||
| 520 | |a BACKGROUND: Renal dysfunction in patients with ST-elevation myocardial infarction (STEMI) undergoing primary percutaneous coronary intervention (pPCI) indicates a poor long-term prognosis. However, the prognostic value of the improvement or stabilisation of renal function during follow-up has not yet been assessed. This study aimed to investigate the long-term predictive impact of the improvement or stabilisation of renal function after one year of follow-up in patients with STEMI undergoing pPCI with renal dysfunction at discharge | ||
| 520 | |a METHODS: This prospective, single-centre cohort study included 2170 consecutive patients with STEMI who underwent pPCI. The glomerular filtration rate (GFR) was determined at hospital discharge and one-year follow-up. The median clinical follow-up was 72 months | ||
| 520 | |a RESULTS: Among the 2004 patients, 393 (19.6%) had a GFR <60 ml/min, and 1611 (80.4%) had a GFR ≥ 60 ml/min at discharge. Among patients with GFR <60 ml/min, data at one-year follow-up were available for 342. Of these patients, 127 (32%) showed improvement in renal function (defined as improvement in the Kidney Disease Improving Global Outcomes (KDIGO) chronic kidney disease (CKD) classification), 47 (12%) showed worsening of renal function (defined as worsening of the KDIGO CKD classification), and 168 (43%) showed no category changes. Improvement or stabilisation of GFR at one year of follow-up was associated with a reduction of major adverse cardiovascular events (MACE) [HR 0.51, 95% CI: 0.35-0.75, p = 0.001] and all-cause mortality [HR 0.54, 95% CI: 0.34-0.84, p = 0.007] during follow-up | ||
| 520 | |a CONCLUSIONS: The improvement or stabilisation of renal function at one-year follow-up in patients with STEMI and renal dysfunction is associated with a better long-term prognosis | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a Improvement or stabilisation of renal function | |
| 650 | 4 | |a Primary percutaneous coronary intervention | |
| 650 | 4 | |a Prognosis | |
| 650 | 4 | |a ST-elevation myocardial infarction | |
| 700 | 1 | |a Otero García, Oscar |e verfasserin |4 aut | |
| 700 | 1 | |a Cid Álvarez, Ana Belén |e verfasserin |4 aut | |
| 700 | 1 | |a Juskova, Mària |e verfasserin |4 aut | |
| 700 | 1 | |a Álvarez Álvarez, Belén |e verfasserin |4 aut | |
| 700 | 1 | |a García Acuña, José María |e verfasserin |4 aut | |
| 700 | 1 | |a Agra Bermejo, Rosa |e verfasserin |4 aut | |
| 700 | 1 | |a Rigueiro Veloso, Pedro |e verfasserin |4 aut | |
| 700 | 1 | |a López Otero, Diego |e verfasserin |4 aut | |
| 700 | 1 | |a Sanmartín Pena, Juan Carlos |e verfasserin |4 aut | |
| 700 | 1 | |a Trillo Nouche, Ramiro |e verfasserin |4 aut | |
| 700 | 1 | |a González-Juanatey, José R |e verfasserin |4 aut | |
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