Antibiotic stability in portable elastomeric infusion devices : A systematic review

© American Society of Health-System Pharmacists 2022. All rights reserved. For permissions, please e-mail: journals.permissionsoup.com..

PURPOSE: Although outpatient parenteral antibiotic therapy (OPAT) can be a good approach to treatment of infections, a lack of data regarding antibiotic stability in portable elastomeric infusion devices restricts its safe, appropriate, and effective use. The objective of this work was to complete a systematic peer-reviewed analysis of published articles about antibiotic stability in elastomeric infusion devices that provide evidence supporting their use in OPAT.

SUMMARY: A systematic review following PRISMA guidelines was conducted in January 2021 to identify published articles about antibiotic stability in portable elastomeric infusion devices. The databases used were PubMed, Embase, Web of Science, and a Cochrane database. A total of 1,615 original studies and conference communications were found. After title, abstract, and full-text review, 33 articles met the inclusion criteria. The data obtained included information about the stability of 30 different antibiotics. To our knowledge, this is the first review to summarize the available published data on the stability of antibiotics in portable elastomeric infusion devices. The results highlight the poor stability of some antibiotics in solution and the variability of the laboratory conditions in the included studies.

CONCLUSION: This systematic review can serve as a useful resource for healthcare professionals involved in providing OPAT using portable elastomeric infusion devices. However, further stability studies should be performed, especially high-quality studies simulating real-life time and temperature conditions.

Medienart:

E-Artikel

Erscheinungsjahr:

2022

Erschienen:

2022

Enthalten in:

Zur Gesamtaufnahme - volume:79

Enthalten in:

American journal of health-system pharmacy : AJHP : official journal of the American Society of Health-System Pharmacists - 79(2022), 16 vom: 05. Aug., Seite 1355-1368

Sprache:

Englisch

Beteiligte Personen:

Esteban-Cartelle, Beatriz [VerfasserIn]
Vicente-Oliveros, Noelia [VerfasserIn]
Pérez Menéndez-Conde, Covadonga [VerfasserIn]
Serrano, Dolores R [VerfasserIn]
Martín-Dávila, Pilar [VerfasserIn]
Fortún-Abete, Jesús [VerfasserIn]
León-Gil, Lourdes A [VerfasserIn]
Álvarez-Díaz, Ana [VerfasserIn]

Links:

Volltext

Themen:

Anti-Bacterial Agents
Antibiotic
Elastomers
Infusion pumps
Journal Article
Outpatient parenteral antimicrobial therapy
Research Support, Non-U.S. Gov't
Stability
Systematic Review

Anmerkungen:

Date Completed 08.08.2022

Date Revised 09.08.2022

published: Print

Citation Status MEDLINE

doi:

10.1093/ajhp/zxac122

funding:

Förderinstitution / Projekttitel:

PPN (Katalog-ID):

NLM340404604