First registry of adult patients with chronic intestinal failure due to short bowel syndrome in Argentina : The RESTORE project
© 2022 American Society for Parenteral and Enteral Nutrition..
BACKGROUND: Short bowel syndrome (SBS) is considered a low prevalence disease. In Argentina, no registries are available on chronic intestinal failure (CIF) and SBS. This project was designed as the first national registry to report adult patients with this disease.
METHODS: A prospective multicenter observational registry was created including adult patients with CIF/SBS from approved centers. Demographics, clinical characteristics, nutrition assessment, home parenteral nutrition (HPN) management, surgeries performed, medical treatment, overall survival, and freedom from HPN survival were analyzed.
RESULTS: Of the 61 enrolled patients, 56 with available follow-up data were analyzed. At enrollment, the mean intestinal length was 59.5 ± 47.3 cm; the anatomy was type 1 (n = 41), type 2 (n = 10), and type 3 (n = 5). At the end of the interim analysis, anatomy changed to type 1 in 31, type 2 in 17, and type 3 in 8 patients. The overall mean time on HPN before enrollment was 33.5 ± 56.2 months. Autologous gastrointestinal reconstruction surgery was performed before enrollment on 21 patients, and afterward on 11. Nine patients (16.1%) were weaned off HPN with standard medical nutrition treatment; 12 patients received enterohormones, and 2 of them suspended HPN; one patient was considered a transplant candidate. In 23.7 ± 14.5 months, 11 of 56 patients discontinued HPN; Kaplan-Meier freedom from HPN survival was 28.9%. The number of cases collected represented 19.6 new adult CIF/SBS patients per year.
CONCLUSION: The RESTORE project allowed us to know the incidence, the current medical and surgical approach for this pathology, as well as its outcome and complications at dedicated centers.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2022 |
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| Erschienen: |
2022 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:46 |
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| Enthalten in: |
JPEN. Journal of parenteral and enteral nutrition - 46(2022), 7 vom: 06. Sept., Seite 1623-1631 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Gondolesi, Gabriel E [VerfasserIn] |
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| Links: |
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| Themen: |
Chronic intestinal failure |
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| Anmerkungen: |
Date Completed 13.09.2022 Date Revised 11.10.2022 published: Print-Electronic Citation Status MEDLINE |
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| doi: |
10.1002/jpen.2387 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM340403470 |
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| 100 | 1 | |a Gondolesi, Gabriel E |e verfasserin |4 aut | |
| 245 | 1 | 0 | |a First registry of adult patients with chronic intestinal failure due to short bowel syndrome in Argentina |b The RESTORE project |
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| 500 | |a Date Revised 11.10.2022 | ||
| 500 | |a published: Print-Electronic | ||
| 500 | |a Citation Status MEDLINE | ||
| 520 | |a © 2022 American Society for Parenteral and Enteral Nutrition. | ||
| 520 | |a BACKGROUND: Short bowel syndrome (SBS) is considered a low prevalence disease. In Argentina, no registries are available on chronic intestinal failure (CIF) and SBS. This project was designed as the first national registry to report adult patients with this disease | ||
| 520 | |a METHODS: A prospective multicenter observational registry was created including adult patients with CIF/SBS from approved centers. Demographics, clinical characteristics, nutrition assessment, home parenteral nutrition (HPN) management, surgeries performed, medical treatment, overall survival, and freedom from HPN survival were analyzed | ||
| 520 | |a RESULTS: Of the 61 enrolled patients, 56 with available follow-up data were analyzed. At enrollment, the mean intestinal length was 59.5 ± 47.3 cm; the anatomy was type 1 (n = 41), type 2 (n = 10), and type 3 (n = 5). At the end of the interim analysis, anatomy changed to type 1 in 31, type 2 in 17, and type 3 in 8 patients. The overall mean time on HPN before enrollment was 33.5 ± 56.2 months. Autologous gastrointestinal reconstruction surgery was performed before enrollment on 21 patients, and afterward on 11. Nine patients (16.1%) were weaned off HPN with standard medical nutrition treatment; 12 patients received enterohormones, and 2 of them suspended HPN; one patient was considered a transplant candidate. In 23.7 ± 14.5 months, 11 of 56 patients discontinued HPN; Kaplan-Meier freedom from HPN survival was 28.9%. The number of cases collected represented 19.6 new adult CIF/SBS patients per year | ||
| 520 | |a CONCLUSION: The RESTORE project allowed us to know the incidence, the current medical and surgical approach for this pathology, as well as its outcome and complications at dedicated centers | ||
| 650 | 4 | |a Journal Article | |
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| 650 | 4 | |a Research Support, Non-U.S. Gov't | |
| 650 | 4 | |a chronic intestinal failure | |
| 650 | 4 | |a enterohormones | |
| 650 | 4 | |a home parenteral nutrition | |
| 650 | 4 | |a intestinal rehabilitation | |
| 650 | 4 | |a short bowel syndrome | |
| 700 | 1 | |a Ortega, Mariana L |e verfasserin |4 aut | |
| 700 | 1 | |a Doeyo, Mariana |e verfasserin |4 aut | |
| 700 | 1 | |a Buncuga, Martin |e verfasserin |4 aut | |
| 700 | 1 | |a Pérez, Claudia |e verfasserin |4 aut | |
| 700 | 1 | |a Mauriño, Eduardo |e verfasserin |4 aut | |
| 700 | 1 | |a Costa, Florencia |e verfasserin |4 aut | |
| 700 | 1 | |a De Barrio, Silvia |e verfasserin |4 aut | |
| 700 | 1 | |a Manzur, Alejandra |e verfasserin |4 aut | |
| 700 | 1 | |a Donnadio, Luciana |e verfasserin |4 aut | |
| 700 | 1 | |a Matoso, Dolores |e verfasserin |4 aut | |
| 700 | 1 | |a Sánchez Claria, Rodrigo |e verfasserin |4 aut | |
| 700 | 1 | |a Crivelli, Adriana |e verfasserin |4 aut | |
| 700 | 1 | |a Solar, Héctor |e verfasserin |4 aut | |
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