Lipid metabolism after mild cold stress in persons with a cervical spinal cord injury
© 2022. The Author(s), under exclusive licence to International Spinal Cord Society..
STUDY DESIGN: Experimental study.
OBJECTIVES: To compare lipid metabolism in individuals with a cervical spinal cord injury (SCIC) and able-bodied (AB) persons in response to mild cold stress.
SETTINGS: Laboratory of Wakayama Medical University, Japan.
METHODS: Nine males with SCIC and 11 AB wore a water-perfusion suit in a supine position. Following 30-min rest thermoneutrality, the whole body was cooled by perfusing 25 °C water through the suit for 15-20 min (CS). Blood samples were collected before, immediately, and 60 (post-CS60) and 120 min after CS (post-CS120). Concentrations of serum free fatty acid ([FFA]s), total ketone bodies ([tKB]s), insulin ([Ins]s) and plasma adrenaline ([Ad]p), noradrenaline ([NA]p) and glucose ([Glc]p) were assessed.
RESULTS: [Ad]p in SCIC were lower than AB throughout the study (p = 0.0002) and remained largely unchanged in both groups. [NA]p increased after cold stress in AB only (p < 0.0001; GxT p = 0.006). [FFA]s increased by 62% immediately after cold stress in SCIC (p = 0.0028), without a difference between groups (p = 0.65). [tKB]s increased by 69% at post-CS60 and 132% at post-CS120 from the start in SCIC with no differences between groups (p = 0.54). [Glc]p and [Ins]s were reduced in SCIc only (GxT p = 0.003 and p = 0.001, respectively).
CONCLUSION: These data indicate that mild cold stress acutely elevates lipid and ketone body metabolism in persons with SCIc, despite the presence of sympathetic dysfunction.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2022 |
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| Erschienen: |
2022 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:60 |
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| Enthalten in: |
Spinal cord - 60(2022), 11 vom: 04. Nov., Seite 978-983 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Nishiyama, Kazunari [VerfasserIn] |
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| Links: |
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| Themen: |
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| Anmerkungen: |
Date Completed 07.11.2022 Date Revised 05.12.2022 published: Print-Electronic Citation Status MEDLINE |
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| doi: |
10.1038/s41393-022-00788-9 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM340371951 |
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| 100 | 1 | |a Nishiyama, Kazunari |e verfasserin |4 aut | |
| 245 | 1 | 0 | |a Lipid metabolism after mild cold stress in persons with a cervical spinal cord injury |
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| 500 | |a Date Revised 05.12.2022 | ||
| 500 | |a published: Print-Electronic | ||
| 500 | |a Citation Status MEDLINE | ||
| 520 | |a © 2022. The Author(s), under exclusive licence to International Spinal Cord Society. | ||
| 520 | |a STUDY DESIGN: Experimental study | ||
| 520 | |a OBJECTIVES: To compare lipid metabolism in individuals with a cervical spinal cord injury (SCIC) and able-bodied (AB) persons in response to mild cold stress | ||
| 520 | |a SETTINGS: Laboratory of Wakayama Medical University, Japan | ||
| 520 | |a METHODS: Nine males with SCIC and 11 AB wore a water-perfusion suit in a supine position. Following 30-min rest thermoneutrality, the whole body was cooled by perfusing 25 °C water through the suit for 15-20 min (CS). Blood samples were collected before, immediately, and 60 (post-CS60) and 120 min after CS (post-CS120). Concentrations of serum free fatty acid ([FFA]s), total ketone bodies ([tKB]s), insulin ([Ins]s) and plasma adrenaline ([Ad]p), noradrenaline ([NA]p) and glucose ([Glc]p) were assessed | ||
| 520 | |a RESULTS: [Ad]p in SCIC were lower than AB throughout the study (p = 0.0002) and remained largely unchanged in both groups. [NA]p increased after cold stress in AB only (p < 0.0001; GxT p = 0.006). [FFA]s increased by 62% immediately after cold stress in SCIC (p = 0.0028), without a difference between groups (p = 0.65). [tKB]s increased by 69% at post-CS60 and 132% at post-CS120 from the start in SCIC with no differences between groups (p = 0.54). [Glc]p and [Ins]s were reduced in SCIc only (GxT p = 0.003 and p = 0.001, respectively) | ||
| 520 | |a CONCLUSION: These data indicate that mild cold stress acutely elevates lipid and ketone body metabolism in persons with SCIc, despite the presence of sympathetic dysfunction | ||
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| 700 | 1 | |a van der Scheer, Jan W |e verfasserin |4 aut | |
| 700 | 1 | |a Kinoshita, Tokio |e verfasserin |4 aut | |
| 700 | 1 | |a Goosey-Tolfrey, Victoria L |e verfasserin |4 aut | |
| 700 | 1 | |a Hoekstra, Sven P |e verfasserin |4 aut | |
| 700 | 1 | |a Nishimura, Yukihide |e verfasserin |4 aut | |
| 700 | 1 | |a Kawasaki, Takashi |e verfasserin |4 aut | |
| 700 | 1 | |a Ogawa, Takahiro |e verfasserin |4 aut | |
| 700 | 1 | |a Tajima, Fumihiro |e verfasserin |4 aut | |
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