Role of YB-1 in Regulation of Poly(ADP-Ribosylation) Catalyzed by Poly(ADP-Ribose) Polymerases
Poly(ADP-ribosyl)ation is a post-translational modification of proteins that performs an essential regulatory function in the cellular response to DNA damage. The key enzyme synthesizing poly(ADP-ribose) (PAR) in the cells is poly(ADP-ribose) polymerase 1 (PARP1). Understanding the mechanisms of the PARP1 activity regulation within the cells is necessary for development of the PARP1-targeted antitumor therapy. This review is devoted to the studies of the role of the RNA-binding protein YB-1 in the PARP1-catalyzed PARylation. The mechanisms of PARP1 activity stimulation by YB-1 protein can possibly be extended to other RNA-binding proteins involved in the maintenance of the genome stability.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2022 |
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| Erschienen: |
2022 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:87 |
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| Enthalten in: |
Biochemistry. Biokhimiia - 87(2022), Suppl 1 vom: 01. Jan., Seite S32-S0 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Alemasova, Elizaveta E [VerfasserIn] |
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| Links: |
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| Anmerkungen: |
Date Completed 04.05.2022 Date Revised 04.05.2022 published: Print Citation Status MEDLINE |
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| doi: |
10.1134/S0006297922140048 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM340307366 |
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| 520 | |a Poly(ADP-ribosyl)ation is a post-translational modification of proteins that performs an essential regulatory function in the cellular response to DNA damage. The key enzyme synthesizing poly(ADP-ribose) (PAR) in the cells is poly(ADP-ribose) polymerase 1 (PARP1). Understanding the mechanisms of the PARP1 activity regulation within the cells is necessary for development of the PARP1-targeted antitumor therapy. This review is devoted to the studies of the role of the RNA-binding protein YB-1 in the PARP1-catalyzed PARylation. The mechanisms of PARP1 activity stimulation by YB-1 protein can possibly be extended to other RNA-binding proteins involved in the maintenance of the genome stability | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a Review | |
| 650 | 4 | |a RNA-binding protein (RBP) | |
| 650 | 4 | |a Y-box-binding protein 1 (YB-1) | |
| 650 | 4 | |a poly(ADP-ribose) (PAR) | |
| 650 | 4 | |a poly(ADP-ribose) polymerase 1 (PARP1) | |
| 650 | 4 | |a poly(ADP-ribosyl)ation (PARylation) | |
| 650 | 7 | |a Proteins |2 NLM | |
| 650 | 7 | |a Poly Adenosine Diphosphate Ribose |2 NLM | |
| 650 | 7 | |a 26656-46-2 |2 NLM | |
| 650 | 7 | |a Poly(ADP-ribose) Polymerases |2 NLM | |
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| 700 | 1 | |a Naumenko, Konstantin N |e verfasserin |4 aut | |
| 700 | 1 | |a Sukhanova, Maria V |e verfasserin |4 aut | |
| 700 | 1 | |a Lavrik, Olga I |e verfasserin |4 aut | |
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