Outcomes in Patients With Chronic Kidney Disease and End-stage Renal Disease and Durable Left Ventricular Assist Device : Insights From the United States Renal Data System Database
Copyright © 2022 The Authors. Published by Elsevier Inc. All rights reserved..
BACKGROUND: There is paucity of data regarding durable left ventricular assist device (LVAD) outcomes in patients with chronic kidney disease (CKD) stages 3-5 and CKD stage 5 on dialysis (end-stage renal disease [ESRD]).
METHODS AND RESULTS: We conducted a retrospective study of Medicare beneficiaries with ESRD and a 5% sample of patients with CKD with an LVAD (2006-2018) to determine 1-year outcomes using the United States Renal Data System database. The LVAD implantation, comorbidities, and outcomes were identified using appropriate International Classification of Diseases, 9th and 10th edition codes. We identified 496 patients with CKD and 95 patients with ESRD who underwent LVAD implantation. The patients with ESRD were younger (59 years vs 66 years; P < .001), had more Blacks (40% vs 24.6%, P = .009), compared with the CKD group. The 1-year mortality (49.5% vs 30.9%, P < .001) and index mortality (27.4% vs 16.7%, P = .014) rates were higher for patients with ESRD. A subgroup analysis showed significantly higher mortality in ESRD vs CKD 3 (49.5% vs 30.2%, adjusted P = .009), but no significant difference in mortality between stage 3 vs 4/5 (30.2% vs 30.8%, adjusted P = .941). There was no significant difference in secondary outcomes (bleeding, stroke, and sepsis/infection) during follow-up between the 2 groups.
CONCLUSIONS: Patients with ESRD undergoing LVAD implantation had significantly higher index and 1-year mortality rates compared with patients with CKD.
| Medienart: |
E-Artikel |
|---|
| Erscheinungsjahr: |
2022 |
|---|---|
| Erschienen: |
2022 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:28 |
|---|---|
| Enthalten in: |
Journal of cardiac failure - 28(2022), 11 vom: 01. Nov., Seite 1604-1614 |
| Sprache: |
Englisch |
|---|
| Beteiligte Personen: |
Dalia, Tarun [VerfasserIn] |
|---|
| Links: |
|---|
| Themen: |
Chronic kidney disease (CKD) |
|---|
| Anmerkungen: |
Date Completed 15.11.2022 Date Revised 06.12.2022 published: Print-Electronic Citation Status MEDLINE |
|---|
| doi: |
10.1016/j.cardfail.2022.03.355 |
|---|
| funding: |
|
|---|---|
| Förderinstitution / Projekttitel: |
|
| PPN (Katalog-ID): |
NLM339991119 |
|---|
| LEADER | 01000naa a22002652 4500 | ||
|---|---|---|---|
| 001 | NLM339991119 | ||
| 003 | DE-627 | ||
| 005 | 20231226004134.0 | ||
| 007 | cr uuu---uuuuu | ||
| 008 | 231226s2022 xx |||||o 00| ||eng c | ||
| 024 | 7 | |a 10.1016/j.cardfail.2022.03.355 |2 doi | |
| 028 | 5 | 2 | |a pubmed24n1133.xml |
| 035 | |a (DE-627)NLM339991119 | ||
| 035 | |a (NLM)35470059 | ||
| 035 | |a (PII)S1071-9164(22)00488-2 | ||
| 040 | |a DE-627 |b ger |c DE-627 |e rakwb | ||
| 041 | |a eng | ||
| 100 | 1 | |a Dalia, Tarun |e verfasserin |4 aut | |
| 245 | 1 | 0 | |a Outcomes in Patients With Chronic Kidney Disease and End-stage Renal Disease and Durable Left Ventricular Assist Device |b Insights From the United States Renal Data System Database |
| 264 | 1 | |c 2022 | |
| 336 | |a Text |b txt |2 rdacontent | ||
| 337 | |a ƒaComputermedien |b c |2 rdamedia | ||
| 338 | |a ƒa Online-Ressource |b cr |2 rdacarrier | ||
| 500 | |a Date Completed 15.11.2022 | ||
| 500 | |a Date Revised 06.12.2022 | ||
| 500 | |a published: Print-Electronic | ||
| 500 | |a Citation Status MEDLINE | ||
| 520 | |a Copyright © 2022 The Authors. Published by Elsevier Inc. All rights reserved. | ||
| 520 | |a BACKGROUND: There is paucity of data regarding durable left ventricular assist device (LVAD) outcomes in patients with chronic kidney disease (CKD) stages 3-5 and CKD stage 5 on dialysis (end-stage renal disease [ESRD]) | ||
| 520 | |a METHODS AND RESULTS: We conducted a retrospective study of Medicare beneficiaries with ESRD and a 5% sample of patients with CKD with an LVAD (2006-2018) to determine 1-year outcomes using the United States Renal Data System database. The LVAD implantation, comorbidities, and outcomes were identified using appropriate International Classification of Diseases, 9th and 10th edition codes. We identified 496 patients with CKD and 95 patients with ESRD who underwent LVAD implantation. The patients with ESRD were younger (59 years vs 66 years; P < .001), had more Blacks (40% vs 24.6%, P = .009), compared with the CKD group. The 1-year mortality (49.5% vs 30.9%, P < .001) and index mortality (27.4% vs 16.7%, P = .014) rates were higher for patients with ESRD. A subgroup analysis showed significantly higher mortality in ESRD vs CKD 3 (49.5% vs 30.2%, adjusted P = .009), but no significant difference in mortality between stage 3 vs 4/5 (30.2% vs 30.8%, adjusted P = .941). There was no significant difference in secondary outcomes (bleeding, stroke, and sepsis/infection) during follow-up between the 2 groups | ||
| 520 | |a CONCLUSIONS: Patients with ESRD undergoing LVAD implantation had significantly higher index and 1-year mortality rates compared with patients with CKD | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a Left ventricular assist device (LVAD) | |
| 650 | 4 | |a chronic kidney disease (CKD) | |
| 650 | 4 | |a dialysis | |
| 650 | 4 | |a end-stage renal/kidney disease (ESRD) | |
| 650 | 4 | |a mortality | |
| 700 | 1 | |a Chan, Wan-Chi |e verfasserin |4 aut | |
| 700 | 1 | |a Sauer, Andrew J |e verfasserin |4 aut | |
| 700 | 1 | |a Ranka, Sagar |e verfasserin |4 aut | |
| 700 | 1 | |a Goyal, Amandeep |e verfasserin |4 aut | |
| 700 | 1 | |a Mastoris, Ioannis |e verfasserin |4 aut | |
| 700 | 1 | |a Pothuru, Suveenkrishna |e verfasserin |4 aut | |
| 700 | 1 | |a Abicht, Travis |e verfasserin |4 aut | |
| 700 | 1 | |a Danter, Matthew |e verfasserin |4 aut | |
| 700 | 1 | |a Vidic, Andrija |e verfasserin |4 aut | |
| 700 | 1 | |a Gupta, Kamal |e verfasserin |4 aut | |
| 700 | 1 | |a Tedford, Ryan J |e verfasserin |4 aut | |
| 700 | 1 | |a Cowger, Jennifer |e verfasserin |4 aut | |
| 700 | 1 | |a Fang, James C |e verfasserin |4 aut | |
| 700 | 1 | |a Shah, Zubair |e verfasserin |4 aut | |
| 773 | 0 | 8 | |i Enthalten in |t Journal of cardiac failure |d 1995 |g 28(2022), 11 vom: 01. Nov., Seite 1604-1614 |w (DE-627)NLM087692775 |x 1532-8414 |7 nnns |
| 773 | 1 | 8 | |g volume:28 |g year:2022 |g number:11 |g day:01 |g month:11 |g pages:1604-1614 |
| 856 | 4 | 0 | |u http://dx.doi.org/10.1016/j.cardfail.2022.03.355 |3 Volltext |
| 912 | |a GBV_USEFLAG_A | ||
| 912 | |a GBV_NLM | ||
| 951 | |a AR | ||
| 952 | |d 28 |j 2022 |e 11 |b 01 |c 11 |h 1604-1614 | ||