Lung function impairment and risk of incident heart failure : the NHLBI Pooled Cohorts Study
© The Author(s) 2022. Published by Oxford University Press on behalf of European Society of Cardiology. All rights reserved. For permissions, please e-mail: journals.permissionsoup.com..
AIMS: The aim is to evaluate associations of lung function impairment with risk of incident heart failure (HF).
METHODS AND RESULTS: Data were pooled across eight US population-based cohorts that enrolled participants from 1987 to 2004. Participants with self-reported baseline cardiovascular disease were excluded. Spirometry was used to define obstructive [forced expiratory volume in 1 s/forced vital capacity (FEV1/FVC) <0.70] or restrictive (FEV1/FVC ≥0.70, FVC <80%) lung physiology. The incident HF was defined as hospitalization or death caused by HF. In a sub-set, HF events were sub-classified as HF with reduced ejection fraction (HFrEF; EF <50%) or preserved EF (HFpEF; EF ≥50%). The Fine-Gray proportional sub-distribution hazards models were adjusted for sociodemographic factors, smoking, and cardiovascular risk factors. In models of incident HF sub-types, HFrEF, HFpEF, and non-HF mortality were treated as competing risks. Among 31 677 adults, there were 3344 incident HF events over a median follow-up of 21.0 years. Of 2066 classifiable HF events, 1030 were classified as HFrEF and 1036 as HFpEF. Obstructive [adjusted hazard ratio (HR) 1.17, 95% confidence interval (CI) 1.07-1.27] and restrictive physiology (adjusted HR 1.43, 95% CI 1.27-1.62) were associated with incident HF. Obstructive and restrictive ventilatory defects were associated with HFpEF but not HFrEF. The magnitude of the association between restrictive physiology and HFpEF was similar to associations with hypertension, diabetes, and smoking.
CONCLUSION: Lung function impairment was associated with increased risk of incident HF, and particularly incident HFpEF, independent of and to a similar extent as major known cardiovascular risk factors.
| Errataetall: |
CommentIn: Eur Heart J. 2022 Jun 14;43(23):2209-2211. - PMID 35466998 |
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| Medienart: |
E-Artikel |
| Erscheinungsjahr: |
2022 |
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| Erschienen: |
2022 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:43 |
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| Enthalten in: |
European heart journal - 43(2022), 23 vom: 14. Juni, Seite 2196-2208 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Eckhardt, Christina M [VerfasserIn] |
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| Links: |
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| Themen: |
Heart failure |
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| Anmerkungen: |
Date Completed 15.06.2022 Date Revised 07.02.2024 published: Print CommentIn: Eur Heart J. 2022 Jun 14;43(23):2209-2211. - PMID 35466998 Citation Status MEDLINE |
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| doi: |
10.1093/eurheartj/ehac205 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| 100 | 1 | |a Eckhardt, Christina M |e verfasserin |4 aut | |
| 245 | 1 | 0 | |a Lung function impairment and risk of incident heart failure |b the NHLBI Pooled Cohorts Study |
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| 500 | |a Date Completed 15.06.2022 | ||
| 500 | |a Date Revised 07.02.2024 | ||
| 500 | |a published: Print | ||
| 500 | |a CommentIn: Eur Heart J. 2022 Jun 14;43(23):2209-2211. - PMID 35466998 | ||
| 500 | |a Citation Status MEDLINE | ||
| 520 | |a © The Author(s) 2022. Published by Oxford University Press on behalf of European Society of Cardiology. All rights reserved. For permissions, please e-mail: journals.permissionsoup.com. | ||
| 520 | |a AIMS: The aim is to evaluate associations of lung function impairment with risk of incident heart failure (HF) | ||
| 520 | |a METHODS AND RESULTS: Data were pooled across eight US population-based cohorts that enrolled participants from 1987 to 2004. Participants with self-reported baseline cardiovascular disease were excluded. Spirometry was used to define obstructive [forced expiratory volume in 1 s/forced vital capacity (FEV1/FVC) <0.70] or restrictive (FEV1/FVC ≥0.70, FVC <80%) lung physiology. The incident HF was defined as hospitalization or death caused by HF. In a sub-set, HF events were sub-classified as HF with reduced ejection fraction (HFrEF; EF <50%) or preserved EF (HFpEF; EF ≥50%). The Fine-Gray proportional sub-distribution hazards models were adjusted for sociodemographic factors, smoking, and cardiovascular risk factors. In models of incident HF sub-types, HFrEF, HFpEF, and non-HF mortality were treated as competing risks. Among 31 677 adults, there were 3344 incident HF events over a median follow-up of 21.0 years. Of 2066 classifiable HF events, 1030 were classified as HFrEF and 1036 as HFpEF. Obstructive [adjusted hazard ratio (HR) 1.17, 95% confidence interval (CI) 1.07-1.27] and restrictive physiology (adjusted HR 1.43, 95% CI 1.27-1.62) were associated with incident HF. Obstructive and restrictive ventilatory defects were associated with HFpEF but not HFrEF. The magnitude of the association between restrictive physiology and HFpEF was similar to associations with hypertension, diabetes, and smoking | ||
| 520 | |a CONCLUSION: Lung function impairment was associated with increased risk of incident HF, and particularly incident HFpEF, independent of and to a similar extent as major known cardiovascular risk factors | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a Research Support, N.I.H., Intramural | |
| 650 | 4 | |a Research Support, Non-U.S. Gov't | |
| 650 | 4 | |a Research Support, N.I.H., Extramural | |
| 650 | 4 | |a Heart failure | |
| 650 | 4 | |a Lung function | |
| 650 | 4 | |a Prospective cohort study | |
| 650 | 4 | |a Spirometry | |
| 700 | 1 | |a Balte, Pallavi P |e verfasserin |4 aut | |
| 700 | 1 | |a Barr, Robert Graham |e verfasserin |4 aut | |
| 700 | 1 | |a Bertoni, Alain G |e verfasserin |4 aut | |
| 700 | 1 | |a Bhatt, Surya P |e verfasserin |4 aut | |
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| 700 | 1 | |a O'Connor, George T |e verfasserin |4 aut | |
| 700 | 1 | |a Rosamond, Wayne |e verfasserin |4 aut | |
| 700 | 1 | |a Sanders, Jason |e verfasserin |4 aut | |
| 700 | 1 | |a Schwartz, Joseph E |e verfasserin |4 aut | |
| 700 | 1 | |a Shah, Amil |e verfasserin |4 aut | |
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| 700 | 1 | |a Yende, Sachin |e verfasserin |4 aut | |
| 700 | 1 | |a Oelsner, Elizabeth C |e verfasserin |4 aut | |
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