The Gut Axis Involvement in Heart Failure : Focus on Trimethylamine N-oxide
Copyright © 2021 Elsevier Inc. All rights reserved..
A novel pathophysiological model of interest is the association between heart failure (HF) and the gastrointestinal system, the 'gut hypothesis'. The choline and carnitine metabolic by-product, Trimethylamine N-oxide (TMAO) is one of the more prominent molecules associated with the link between HF and the gut. Indeed, TMAO levels are increased in HF populations and higher TMAO levels are associated with poor prognosis, whereas low TMAO levels either at baseline/follow up confer better prognosis. Considering that TMAO levels seem not to be affected by guideline-HF treatment, this model could represent a novel and independent therapeutic target for HF.
| Medienart: |
E-Artikel |
|---|
| Erscheinungsjahr: |
2022 |
|---|---|
| Erschienen: |
2022 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:40 |
|---|---|
| Enthalten in: |
Cardiology clinics - 40(2022), 2 vom: 01. Mai, Seite 161-169 |
| Sprache: |
Englisch |
|---|
| Beteiligte Personen: |
Salzano, Andrea [VerfasserIn] |
|---|
| Links: |
|---|
| Themen: |
Cardiovascular disease |
|---|
| Anmerkungen: |
Date Completed 26.04.2022 Date Revised 15.03.2023 published: Print Citation Status MEDLINE |
|---|
| doi: |
10.1016/j.ccl.2021.12.004 |
|---|
| funding: |
|
|---|---|
| Förderinstitution / Projekttitel: |
|
| PPN (Katalog-ID): |
NLM339950064 |
|---|
| LEADER | 01000naa a22002652 4500 | ||
|---|---|---|---|
| 001 | NLM339950064 | ||
| 003 | DE-627 | ||
| 005 | 20231226004038.0 | ||
| 007 | cr uuu---uuuuu | ||
| 008 | 231226s2022 xx |||||o 00| ||eng c | ||
| 024 | 7 | |a 10.1016/j.ccl.2021.12.004 |2 doi | |
| 028 | 5 | 2 | |a pubmed24n1133.xml |
| 035 | |a (DE-627)NLM339950064 | ||
| 035 | |a (NLM)35465890 | ||
| 035 | |a (PII)S0733-8651(21)00104-1 | ||
| 040 | |a DE-627 |b ger |c DE-627 |e rakwb | ||
| 041 | |a eng | ||
| 100 | 1 | |a Salzano, Andrea |e verfasserin |4 aut | |
| 245 | 1 | 4 | |a The Gut Axis Involvement in Heart Failure |b Focus on Trimethylamine N-oxide |
| 264 | 1 | |c 2022 | |
| 336 | |a Text |b txt |2 rdacontent | ||
| 337 | |a ƒaComputermedien |b c |2 rdamedia | ||
| 338 | |a ƒa Online-Ressource |b cr |2 rdacarrier | ||
| 500 | |a Date Completed 26.04.2022 | ||
| 500 | |a Date Revised 15.03.2023 | ||
| 500 | |a published: Print | ||
| 500 | |a Citation Status MEDLINE | ||
| 520 | |a Copyright © 2021 Elsevier Inc. All rights reserved. | ||
| 520 | |a A novel pathophysiological model of interest is the association between heart failure (HF) and the gastrointestinal system, the 'gut hypothesis'. The choline and carnitine metabolic by-product, Trimethylamine N-oxide (TMAO) is one of the more prominent molecules associated with the link between HF and the gut. Indeed, TMAO levels are increased in HF populations and higher TMAO levels are associated with poor prognosis, whereas low TMAO levels either at baseline/follow up confer better prognosis. Considering that TMAO levels seem not to be affected by guideline-HF treatment, this model could represent a novel and independent therapeutic target for HF | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a Review | |
| 650 | 4 | |a Cardiovascular disease | |
| 650 | 4 | |a Gut | |
| 650 | 4 | |a Heart failure | |
| 650 | 4 | |a Prognosis | |
| 650 | 4 | |a Risk stratification | |
| 650 | 4 | |a TMAO | |
| 650 | 7 | |a Methylamines |2 NLM | |
| 650 | 7 | |a trimethyloxamine |2 NLM | |
| 650 | 7 | |a FLD0K1SJ1A |2 NLM | |
| 650 | 7 | |a Choline |2 NLM | |
| 650 | 7 | |a N91BDP6H0X |2 NLM | |
| 700 | 1 | |a Cassambai, Shabana |e verfasserin |4 aut | |
| 700 | 1 | |a Yazaki, Yoshiyuki |e verfasserin |4 aut | |
| 700 | 1 | |a Israr, Muhammad Zubair |e verfasserin |4 aut | |
| 700 | 1 | |a Bernieh, Dennis |e verfasserin |4 aut | |
| 700 | 1 | |a Wong, Max |e verfasserin |4 aut | |
| 700 | 1 | |a Suzuki, Toru |e verfasserin |4 aut | |
| 773 | 0 | 8 | |i Enthalten in |t Cardiology clinics |d 1993 |g 40(2022), 2 vom: 01. Mai, Seite 161-169 |w (DE-627)NLM013526138 |x 1558-2264 |7 nnns |
| 773 | 1 | 8 | |g volume:40 |g year:2022 |g number:2 |g day:01 |g month:05 |g pages:161-169 |
| 856 | 4 | 0 | |u http://dx.doi.org/10.1016/j.ccl.2021.12.004 |3 Volltext |
| 912 | |a GBV_USEFLAG_A | ||
| 912 | |a GBV_NLM | ||
| 951 | |a AR | ||
| 952 | |d 40 |j 2022 |e 2 |b 01 |c 05 |h 161-169 | ||