Are Dyskeratosis Congenita patients at higher risk of symptomatic COVID-19?
© 2022 Elsevier Ltd. All rights reserved..
Dyskeratosis Congenita (DC) is a rare and heterogeneous disease. This disorder is resulted from a defect in the telomere maintenance in stem cells. Telomerase RNA component, shelterin complex, and telomerase reverse transcriptase are mutated in this disease. Many studies have previously confirmed shorter leukocyte telomere length in DC. On the other hand, the association between telomere length and Coronavirus disease 2019 (COVID-19) indicated that people with a short telomere background mostly show more severe symptoms related to COVID-19, and the mortality rate among them increases as well. Because patients with DC have an abnormally short telomere length, in the current study, we hypothesized that they are at higher risk of developing symptomatic COVID-19 that requires further clinical care.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2022 |
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| Erschienen: |
2022 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:163 |
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| Enthalten in: |
Medical hypotheses - 163(2022) vom: 15. Juni, Seite 110843 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Naghipoor, Karim [VerfasserIn] |
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| Links: |
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| Themen: |
BMF, Bone Marrow Failure |
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| Anmerkungen: |
Date Revised 21.12.2022 published: Print-Electronic Citation Status PubMed-not-MEDLINE |
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| doi: |
10.1016/j.mehy.2022.110843 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| 520 | |a © 2022 Elsevier Ltd. All rights reserved. | ||
| 520 | |a Dyskeratosis Congenita (DC) is a rare and heterogeneous disease. This disorder is resulted from a defect in the telomere maintenance in stem cells. Telomerase RNA component, shelterin complex, and telomerase reverse transcriptase are mutated in this disease. Many studies have previously confirmed shorter leukocyte telomere length in DC. On the other hand, the association between telomere length and Coronavirus disease 2019 (COVID-19) indicated that people with a short telomere background mostly show more severe symptoms related to COVID-19, and the mortality rate among them increases as well. Because patients with DC have an abnormally short telomere length, in the current study, we hypothesized that they are at higher risk of developing symptomatic COVID-19 that requires further clinical care | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a BMF, Bone Marrow Failure | |
| 650 | 4 | |a COVID-19 | |
| 650 | 4 | |a COVID-19, Coronavirus disease 2019 | |
| 650 | 4 | |a DC, Dyskeratosis Congenita | |
| 650 | 4 | |a Dyskeratosis Congenita | |
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| 650 | 4 | |a Telomere Length | |
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| 700 | 1 | |a Vahidnezhad, Hassan |e verfasserin |4 aut | |
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