Insulin-like growth factor-1 (IGF-1) as predictor of cardiovascular mortality in heart failure patients : data from the T.O.S.CA. registry
© 2022. The Author(s)..
INTRODUCTION: Data from the "Trattamento Ormonale nello Scompenso CArdiaco" (T.O.S.CA) registry showed that heart failure (HF) represents a complex clinical syndrome with different hormonal alterations. Renal failure represents a frequent complication in HF. We evaluated the relationship between renal function and insuline-like growth factor-1 (IGF-1) deficiency and its impact on cardiovascular mortality (CVM) in patients enrolled in the T.O.S.CA. registry.
METHODS: At the enrolment, all subjects underwent chemistry examinations, including circulating hormones and cardiovascular functional tests. COX regression analysis was used to evaluate factors related to CVM during the follow-up period in all populations, in high-risk patients and in the young-adult population. Also, we evaluate the effects of renal function on the CVM.
RESULTS: 337 patients (41 deceased) were analyzed. CVM was related to severe renal dysfunction (HR stages IV-V = 4.86), high-risk conditions (HR 2.25), serum IGF-1 (HR 0.42), and HF etiology (HR 5.85 and HR 1.63 for valvular and ischemic etiology, respectively). In high-risk patients, CVM was related to IGF-1 levels, severe renal dysfunction and valvular etiology, whereas in young patients CMV was related to the high-risk pattern and serum IGF-1 levels.
CONCLUSIONS: Our study showed the clinical and prognostic utility of the IGF-1 assay in patients with HF.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2022 |
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| Erschienen: |
2022 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:17 |
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| Enthalten in: |
Internal and emergency medicine - 17(2022), 6 vom: 21. Sept., Seite 1651-1660 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
De Giorgi, Alfredo [VerfasserIn] |
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| Links: |
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| Anmerkungen: |
Date Completed 13.09.2022 Date Revised 11.10.2022 published: Print-Electronic Citation Status MEDLINE |
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| doi: |
10.1007/s11739-022-02980-4 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| 100 | 1 | |a De Giorgi, Alfredo |e verfasserin |4 aut | |
| 245 | 1 | 0 | |a Insulin-like growth factor-1 (IGF-1) as predictor of cardiovascular mortality in heart failure patients |b data from the T.O.S.CA. registry |
| 264 | 1 | |c 2022 | |
| 336 | |a Text |b txt |2 rdacontent | ||
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| 500 | |a Date Completed 13.09.2022 | ||
| 500 | |a Date Revised 11.10.2022 | ||
| 500 | |a published: Print-Electronic | ||
| 500 | |a Citation Status MEDLINE | ||
| 520 | |a © 2022. The Author(s). | ||
| 520 | |a INTRODUCTION: Data from the "Trattamento Ormonale nello Scompenso CArdiaco" (T.O.S.CA) registry showed that heart failure (HF) represents a complex clinical syndrome with different hormonal alterations. Renal failure represents a frequent complication in HF. We evaluated the relationship between renal function and insuline-like growth factor-1 (IGF-1) deficiency and its impact on cardiovascular mortality (CVM) in patients enrolled in the T.O.S.CA. registry | ||
| 520 | |a METHODS: At the enrolment, all subjects underwent chemistry examinations, including circulating hormones and cardiovascular functional tests. COX regression analysis was used to evaluate factors related to CVM during the follow-up period in all populations, in high-risk patients and in the young-adult population. Also, we evaluate the effects of renal function on the CVM | ||
| 520 | |a RESULTS: 337 patients (41 deceased) were analyzed. CVM was related to severe renal dysfunction (HR stages IV-V = 4.86), high-risk conditions (HR 2.25), serum IGF-1 (HR 0.42), and HF etiology (HR 5.85 and HR 1.63 for valvular and ischemic etiology, respectively). In high-risk patients, CVM was related to IGF-1 levels, severe renal dysfunction and valvular etiology, whereas in young patients CMV was related to the high-risk pattern and serum IGF-1 levels | ||
| 520 | |a CONCLUSIONS: Our study showed the clinical and prognostic utility of the IGF-1 assay in patients with HF | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a Chronic heart failure | |
| 650 | 4 | |a Chronic renal failure | |
| 650 | 4 | |a Heart failure with reduced ejection fraction | |
| 650 | 4 | |a IGF-1 deficiency | |
| 650 | 4 | |a Multiple hormonal deficiency syndrome | |
| 650 | 7 | |a IGF1 protein, human |2 NLM | |
| 650 | 7 | |a Insulin-Like Growth Factor I |2 NLM | |
| 650 | 7 | |a 67763-96-6 |2 NLM | |
| 700 | 1 | |a Marra, Alberto Maria |e verfasserin |4 aut | |
| 700 | 1 | |a Iacoviello, Massimo |e verfasserin |4 aut | |
| 700 | 1 | |a Triggiani, Vincenzo |e verfasserin |4 aut | |
| 700 | 1 | |a Rengo, Giuseppe |e verfasserin |4 aut | |
| 700 | 1 | |a Cacciatore, Francesco |e verfasserin |4 aut | |
| 700 | 1 | |a Maiello, Ciro |e verfasserin |4 aut | |
| 700 | 1 | |a Limongelli, Giuseppe |e verfasserin |4 aut | |
| 700 | 1 | |a Masarone, Daniele |e verfasserin |4 aut | |
| 700 | 1 | |a Perticone, Francesco |e verfasserin |4 aut | |
| 700 | 1 | |a Filardi, Pasquale Perrone |e verfasserin |4 aut | |
| 700 | 1 | |a Paolillo, Stefania |e verfasserin |4 aut | |
| 700 | 1 | |a Mancini, Antonio |e verfasserin |4 aut | |
| 700 | 1 | |a Volterrani, Maurizio |e verfasserin |4 aut | |
| 700 | 1 | |a Vriz, Olga |e verfasserin |4 aut | |
| 700 | 1 | |a Castello, Roberto |e verfasserin |4 aut | |
| 700 | 1 | |a Passantino, Andrea |e verfasserin |4 aut | |
| 700 | 1 | |a Campo, Michela |e verfasserin |4 aut | |
| 700 | 1 | |a Modesti, Pietro Amedeo |e verfasserin |4 aut | |
| 700 | 1 | |a Salzano, Andrea |e verfasserin |4 aut | |
| 700 | 1 | |a D'Assante, Roberta |e verfasserin |4 aut | |
| 700 | 1 | |a Arcopinto, Michele |e verfasserin |4 aut | |
| 700 | 1 | |a Raparelli, Valeria |e verfasserin |4 aut | |
| 700 | 1 | |a Fabbian, Fabio |e verfasserin |4 aut | |
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| 700 | 1 | |a Colao, Annamaria |e verfasserin |4 aut | |
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| 700 | 1 | |a Bossone, Eduardo |e verfasserin |4 aut | |
| 700 | 1 | |a Cittadini, Antonio |e verfasserin |4 aut | |
| 700 | 0 | |a T.O.S.CA. Investigators |e verfasserin |4 aut | |
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| 700 | 1 | |a Saccà, L |e investigator |4 oth | |
| 700 | 1 | |a Monti, M G |e investigator |4 oth | |
| 700 | 1 | |a Napoli, R |e investigator |4 oth | |
| 700 | 1 | |a Matarazzo, M |e investigator |4 oth | |
| 700 | 1 | |a Stagnaro, F M |e investigator |4 oth | |
| 700 | 1 | |a Schiavo, A |e investigator |4 oth | |
| 700 | 1 | |a Valente, P |e investigator |4 oth | |
| 700 | 1 | |a Bossone, E |e investigator |4 oth | |
| 700 | 1 | |a Ferrara, F |e investigator |4 oth | |
| 700 | 1 | |a Russo, V |e investigator |4 oth | |
| 700 | 1 | |a Malinconico, M |e investigator |4 oth | |
| 700 | 1 | |a Citro, R |e investigator |4 oth | |
| 700 | 1 | |a Guastalamacchia, E |e investigator |4 oth | |
| 700 | 1 | |a Iacoviello, M |e investigator |4 oth | |
| 700 | 1 | |a Leone, M |e investigator |4 oth | |
| 700 | 1 | |a Triggiani, V |e investigator |4 oth | |
| 700 | 1 | |a Cacciatore, F |e investigator |4 oth | |
| 700 | 1 | |a Maiello, C |e investigator |4 oth | |
| 700 | 1 | |a Amarelli, C |e investigator |4 oth | |
| 700 | 1 | |a Mattucci, I |e investigator |4 oth | |
| 700 | 1 | |a Limongelli, G |e investigator |4 oth | |
| 700 | 1 | |a Masarone, D |e investigator |4 oth | |
| 700 | 1 | |a Calabrò, P |e investigator |4 oth | |
| 700 | 1 | |a Calabrò, R |e investigator |4 oth | |
| 700 | 1 | |a D'Andrea, A |e investigator |4 oth | |
| 700 | 1 | |a Maddaloni, V |e investigator |4 oth | |
| 700 | 1 | |a Pacileo, G |e investigator |4 oth | |
| 700 | 1 | |a Scarafile, R |e investigator |4 oth | |
| 700 | 1 | |a Perticone, F |e investigator |4 oth | |
| 700 | 1 | |a Belfiore, A |e investigator |4 oth | |
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| 700 | 1 | |a Filardi, P Perrone |e investigator |4 oth | |
| 700 | 1 | |a Casaretti, L |e investigator |4 oth | |
| 700 | 1 | |a Paolillo, S |e investigator |4 oth | |
| 700 | 1 | |a Gargiulo, P |e investigator |4 oth | |
| 700 | 1 | |a Mancini, A |e investigator |4 oth | |
| 700 | 1 | |a Favuzzi, A M R |e investigator |4 oth | |
| 700 | 1 | |a Di Segni, C |e investigator |4 oth | |
| 700 | 1 | |a Bruno, C |e investigator |4 oth | |
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| 700 | 1 | |a Vriz, O |e investigator |4 oth | |
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| 700 | 1 | |a Ragusa, L |e investigator |4 oth | |
| 700 | 1 | |a Caliendo, L |e investigator |4 oth | |
| 700 | 1 | |a Carbone, L |e investigator |4 oth | |
| 700 | 1 | |a Frigiola, A |e investigator |4 oth | |
| 700 | 1 | |a Generali, T |e investigator |4 oth | |
| 700 | 1 | |a Giacomazzi, F |e investigator |4 oth | |
| 700 | 1 | |a De Vincentiis, C |e investigator |4 oth | |
| 700 | 1 | |a Ballotta, A |e investigator |4 oth | |
| 700 | 1 | |a Garofalo, P |e investigator |4 oth | |
| 700 | 1 | |a Malizia, G |e investigator |4 oth | |
| 700 | 1 | |a Suzuki, T |e investigator |4 oth | |
| 700 | 1 | |a Heaney, L M |e investigator |4 oth | |
| 700 | 1 | |a Bruzzese, D |e investigator |4 oth | |
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