Mucormycosis and Covid-19 : Risk Factors, Clinical Presentation and Outcome in a Tertiary Care Centre in North India
© Journal of the Association of Physicians of India 2011..
A wide range of opportunistic infections have been described in patients with Coronavirus disease 2019 (COVID-19). Aspergillus and Candida have been reported as the main fungal pathogens for co-infection in these patients. Mucormycosis including Rhino-Orbital-Cerebral Mucormycosis (ROCM) has been increasingly described in patients with COVID-19 disease but the risk factors and outcome of such patients are not well described.
MATERIAL: This prospective observational study was conducted at a tertiary centre in North India of 50 patients with radiologically and microbiologically proven Mucormycosis.
OBSERVATION: The included subjects were evaluated for the risk factors, the clinical presentation, and outcomes. Frequency(t=50) Percentage 1 Age Below 40 10 20 40 and above 40 80 2 Sex F 21 42 M 29 58 3 Covid 19 history positive 39 78 negative 4 8 nr 7 14 4 HTN history Present 21 42 absent 29 58 5 Diabetes history present 42 84 absent 8 16 6 Duration of DM <1 month 8 16 >1 month 26 52 NR 16 32 7 Vaccination Status Vaccinated 2 4 Not vaccinated 48 96 8 HbA1c <6.5 7 14 6.5 to 7 7 14 >7 27 54 9 History of hospital/ home oxygen Present 17 34 absent 33 66 10 SpO2 during admission <90 1 2 90to95 8 16 >95 37 74 No record available 4 8 11 pH at admission <7.35 4 8 7.35 to 7.45 16 32 >7.45 7 14 Data not available 23 46 12 TLC <4400 1 2 4400 to 10900 27 54 >11000 16 32 Data Not available 6 12 Steroid Use in Hospital Stay prednisolone 2 4 Dexamethasone 23 46 13 Hydrocortisone 1 2 Methylprednisolone 1 2 Unavailable 4 8 Not received 19 38 14 Outcome Discharged 41 82 Expired 6 12 Absconded 3 6.
CONCLUSION: Out of the 50 patients under study, 78% had Covid-19 disease. The primary risk factor of Mucor in patients of Covid-19 was Diabetes Mellitus (84%) with known diabetics (52%) having uncontrolled hyperglycemia (54%) and those who required oxygen support (home/ hospital) (32%). Mucor was more common in males (58%) of age 40 years and above (80%). About 96% of these patients were not vaccinated against Covid-19, and only 42% had a history of Hypertension. Dexamethasone was used in 46% of the patients admitted and 82% were discharged with satisfactory recovery.
| Medienart: |
Artikel |
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| Erscheinungsjahr: |
2022 |
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| Erschienen: |
2022 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:70 |
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| Enthalten in: |
The Journal of the Association of Physicians of India - 70(2022), 4 vom: 10. Apr., Seite 11-12 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
A, Ghayas Ansari [VerfasserIn] |
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| Themen: |
7S5I7G3JQL |
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| Anmerkungen: |
Date Completed 22.04.2022 Date Revised 22.04.2022 published: Print Citation Status MEDLINE |
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| Förderinstitution / Projekttitel: |
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NLM339727721 |
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| 245 | 1 | 0 | |a Mucormycosis and Covid-19 |b Risk Factors, Clinical Presentation and Outcome in a Tertiary Care Centre in North India |
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| 520 | |a © Journal of the Association of Physicians of India 2011. | ||
| 520 | |a A wide range of opportunistic infections have been described in patients with Coronavirus disease 2019 (COVID-19). Aspergillus and Candida have been reported as the main fungal pathogens for co-infection in these patients. Mucormycosis including Rhino-Orbital-Cerebral Mucormycosis (ROCM) has been increasingly described in patients with COVID-19 disease but the risk factors and outcome of such patients are not well described | ||
| 520 | |a MATERIAL: This prospective observational study was conducted at a tertiary centre in North India of 50 patients with radiologically and microbiologically proven Mucormycosis | ||
| 520 | |a OBSERVATION: The included subjects were evaluated for the risk factors, the clinical presentation, and outcomes. Frequency(t=50) Percentage 1 Age Below 40 10 20 40 and above 40 80 2 Sex F 21 42 M 29 58 3 Covid 19 history positive 39 78 negative 4 8 nr 7 14 4 HTN history Present 21 42 absent 29 58 5 Diabetes history present 42 84 absent 8 16 6 Duration of DM <1 month 8 16 >1 month 26 52 NR 16 32 7 Vaccination Status Vaccinated 2 4 Not vaccinated 48 96 8 HbA1c <6.5 7 14 6.5 to 7 7 14 >7 27 54 9 History of hospital/ home oxygen Present 17 34 absent 33 66 10 SpO2 during admission <90 1 2 90to95 8 16 >95 37 74 No record available 4 8 11 pH at admission <7.35 4 8 7.35 to 7.45 16 32 >7.45 7 14 Data not available 23 46 12 TLC <4400 1 2 4400 to 10900 27 54 >11000 16 32 Data Not available 6 12 Steroid Use in Hospital Stay prednisolone 2 4 Dexamethasone 23 46 13 Hydrocortisone 1 2 Methylprednisolone 1 2 Unavailable 4 8 Not received 19 38 14 Outcome Discharged 41 82 Expired 6 12 Absconded 3 6 | ||
| 520 | |a CONCLUSION: Out of the 50 patients under study, 78% had Covid-19 disease. The primary risk factor of Mucor in patients of Covid-19 was Diabetes Mellitus (84%) with known diabetics (52%) having uncontrolled hyperglycemia (54%) and those who required oxygen support (home/ hospital) (32%). Mucor was more common in males (58%) of age 40 years and above (80%). About 96% of these patients were not vaccinated against Covid-19, and only 42% had a history of Hypertension. Dexamethasone was used in 46% of the patients admitted and 82% were discharged with satisfactory recovery | ||
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| 700 | 1 | |a HaiderMehdi, Husaini S |e verfasserin |4 aut | |
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