Neonatal Intensive Care Unit Network Neurobehavioral Scale Profiles in Full-Term Infants : Associations with Maternal Adversity, Medical Risk, and Neonatal Outcomes
Copyright © 2022 Elsevier Inc. All rights reserved..
OBJECTIVES: To examine healthy, full-term neonatal behavior using the Neonatal Intensive Care Unit Network Neurobehavioral Scale (NNNS) in relation to measures of maternal adversity, maternal medical risk, and infant brain volumes.
STUDY DESIGN: This was a prospective, longitudinal, observational cohort study of pregnant mothers followed from the first trimester and their healthy, full-term infants. Infants underwent an NNNS assessment and high-quality magnetic resonance imaging 2-5 weeks after birth. A latent profile analysis of NNNS scores categorized infants into neurobehavioral profiles. Univariate and multivariate analyses compared differences in maternal factors (social advantage, psychosocial stress, and medical risk) and neonatal characteristics between profiles.
RESULTS: The latent profile analysis of NNNS summary scales of 296 infants generated 3 profiles: regulated (46.6%), hypotonic (16.6%), and fussy (36.8%). Infants with a hypotonic profile were more likely to be male (χ2 = 8.601; P = .014). Fussy infants had smaller head circumferences (F = 3.871; P = .022) and smaller total brain (F = 3.522; P = .031) and cerebral white matter (F = 3.986; P = .020) volumes compared with infants with a hypotonic profile. There were no differences between profiles in prenatal maternal health, social advantage, or psychosocial stress.
CONCLUSIONS: Three distinct neurobehavioral profiles were identified in healthy, full-term infants with hypotonic and fussy neurobehavioral features related to neonatal brain volumes and head circumference, but not prenatal exposure to socioeconomic or psychosocial adversity. Follow-up beyond the neonatal period will determine if identified profiles at birth are associated with subsequent clinical or developmental outcomes.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2022 |
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| Erschienen: |
2022 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:246 |
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| Enthalten in: |
The Journal of pediatrics - 246(2022) vom: 15. Juli, Seite 71-79.e3 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Parikh, Amisha N [VerfasserIn] |
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| Links: |
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| Themen: |
Journal Article |
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| Anmerkungen: |
Date Completed 28.06.2022 Date Revised 17.01.2024 published: Print-Electronic Citation Status MEDLINE |
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| doi: |
10.1016/j.jpeds.2022.04.016 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM339596864 |
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| 041 | |a eng | ||
| 100 | 1 | |a Parikh, Amisha N |e verfasserin |4 aut | |
| 245 | 1 | 0 | |a Neonatal Intensive Care Unit Network Neurobehavioral Scale Profiles in Full-Term Infants |b Associations with Maternal Adversity, Medical Risk, and Neonatal Outcomes |
| 264 | 1 | |c 2022 | |
| 336 | |a Text |b txt |2 rdacontent | ||
| 337 | |a ƒaComputermedien |b c |2 rdamedia | ||
| 338 | |a ƒa Online-Ressource |b cr |2 rdacarrier | ||
| 500 | |a Date Completed 28.06.2022 | ||
| 500 | |a Date Revised 17.01.2024 | ||
| 500 | |a published: Print-Electronic | ||
| 500 | |a Citation Status MEDLINE | ||
| 520 | |a Copyright © 2022 Elsevier Inc. All rights reserved. | ||
| 520 | |a OBJECTIVES: To examine healthy, full-term neonatal behavior using the Neonatal Intensive Care Unit Network Neurobehavioral Scale (NNNS) in relation to measures of maternal adversity, maternal medical risk, and infant brain volumes | ||
| 520 | |a STUDY DESIGN: This was a prospective, longitudinal, observational cohort study of pregnant mothers followed from the first trimester and their healthy, full-term infants. Infants underwent an NNNS assessment and high-quality magnetic resonance imaging 2-5 weeks after birth. A latent profile analysis of NNNS scores categorized infants into neurobehavioral profiles. Univariate and multivariate analyses compared differences in maternal factors (social advantage, psychosocial stress, and medical risk) and neonatal characteristics between profiles | ||
| 520 | |a RESULTS: The latent profile analysis of NNNS summary scales of 296 infants generated 3 profiles: regulated (46.6%), hypotonic (16.6%), and fussy (36.8%). Infants with a hypotonic profile were more likely to be male (χ2 = 8.601; P = .014). Fussy infants had smaller head circumferences (F = 3.871; P = .022) and smaller total brain (F = 3.522; P = .031) and cerebral white matter (F = 3.986; P = .020) volumes compared with infants with a hypotonic profile. There were no differences between profiles in prenatal maternal health, social advantage, or psychosocial stress | ||
| 520 | |a CONCLUSIONS: Three distinct neurobehavioral profiles were identified in healthy, full-term infants with hypotonic and fussy neurobehavioral features related to neonatal brain volumes and head circumference, but not prenatal exposure to socioeconomic or psychosocial adversity. Follow-up beyond the neonatal period will determine if identified profiles at birth are associated with subsequent clinical or developmental outcomes | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a Observational Study | |
| 650 | 4 | |a Research Support, Non-U.S. Gov't | |
| 650 | 4 | |a Research Support, N.I.H., Extramural | |
| 650 | 4 | |a latent profile analysis | |
| 650 | 4 | |a neonatal brain volumes | |
| 650 | 4 | |a psychological stress | |
| 650 | 4 | |a socioeconomic status | |
| 700 | 1 | |a Triplett, Regina L |e verfasserin |4 aut | |
| 700 | 1 | |a Wu, Tiffany J |e verfasserin |4 aut | |
| 700 | 1 | |a Arora, Jyoti |e verfasserin |4 aut | |
| 700 | 1 | |a Lukas, Karen |e verfasserin |4 aut | |
| 700 | 1 | |a Smyser, Tara A |e verfasserin |4 aut | |
| 700 | 1 | |a Miller, J Philip |e verfasserin |4 aut | |
| 700 | 1 | |a Luby, Joan L |e verfasserin |4 aut | |
| 700 | 1 | |a Rogers, Cynthia E |e verfasserin |4 aut | |
| 700 | 1 | |a Barch, Deanna M |e verfasserin |4 aut | |
| 700 | 1 | |a Warner, Barbara B |e verfasserin |4 aut | |
| 700 | 1 | |a Smyser, Christopher D |e verfasserin |4 aut | |
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