A conserved interplay between FOXO and SNAI/snail in autophagy
Dysfunction of macroautophagy/autophagy has been implicated in homeostasis maintenance and contributes to various diseases. Yet the mechanisms that regulate autophagy have not been fully understood. In a recent study, we uncovered a coherent FOXO3-SNAI2 feed-forward regulatory loop in mammals that reinforces autophagy gene induction upon energy stress. Strikingly, a foxo-sna (snail) feed-forward circuit also exists in Drosophila, suggesting this regulating loop is evolutionarily conserved. Moreover, our results highlight that binding of FOXO3 to the DNA appears to be both necessary and sufficient to antagonize CRM1-dependent nuclear export, illustrating a critical role of DNA in regulating protein nuclear localization.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2022 |
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| Erschienen: |
2022 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:18 |
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| Enthalten in: |
Autophagy - 18(2022), 11 vom: 17. Nov., Seite 2759-2760 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Guo, Xiaowei [VerfasserIn] |
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| Links: |
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| Themen: |
Autophagy |
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| Anmerkungen: |
Date Completed 01.11.2022 Date Revised 16.04.2023 published: Print-Electronic Citation Status MEDLINE |
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| doi: |
10.1080/15548627.2022.2063559 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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NLM339516615 |
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| 520 | |a Dysfunction of macroautophagy/autophagy has been implicated in homeostasis maintenance and contributes to various diseases. Yet the mechanisms that regulate autophagy have not been fully understood. In a recent study, we uncovered a coherent FOXO3-SNAI2 feed-forward regulatory loop in mammals that reinforces autophagy gene induction upon energy stress. Strikingly, a foxo-sna (snail) feed-forward circuit also exists in Drosophila, suggesting this regulating loop is evolutionarily conserved. Moreover, our results highlight that binding of FOXO3 to the DNA appears to be both necessary and sufficient to antagonize CRM1-dependent nuclear export, illustrating a critical role of DNA in regulating protein nuclear localization | ||
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