Contribution of cardio-vascular risk factors to depressive status in the PREDIMED-PLUS Trial. A cross-sectional and a 2-year longitudinal study
BACKGROUND: Cardio-vascular disease and depression are thought to be closely related, due to shared risk factors. The aim of the study was to determine the association between cardio-vascular risk (CVR) factors and depressive status in a population (55-75 years) with metabolic syndrome (MetS) from the PREDIMED-Plus trial.
METHODS AND FINDINGS: Participants were classified into three groups of CVR according to the Framingham-based REGICOR function: (1) low (LR), (2) medium (MR) or (3) high/very high (HR). The Beck Depression Inventory-II (BDI-II) was used to assess depressive symptoms at baseline and after 2 years. The association between CVR and depressive status at baseline (n = 6545), and their changes after 2 years (n = 4566) were evaluated through multivariable regression models (logistic and linear models). HR women showed higher odds of depressive status than LR [OR (95% CI) = 1.78 (1.26, 2.50)]. MR and HR participants with total cholesterol <160 mg/mL showed higher odds of depression than LR [OR (95% CI) = 1.77 (1.13, 2.77) and 2.83 (1.25, 6.42) respectively)] but those with total cholesterol ≥280 mg/mL showed lower odds of depression than LR [OR (95% CI) = 0.26 (0.07, 0.98) and 0.23 (0.05, 0.95), respectively]. All participants decreased their BDI-II score after 2 years, being the decrease smaller in MR and HR diabetic compared to LR [adjusted mean±SE = -0.52±0.20, -0.41±0.27 and -1.25±0.31 respectively). MR and HR participants with total cholesterol between 240-279 mg/mL showed greater decreases in the BDI-II score compared to LR (adjusted mean±SE = -0.83±0.37, -0.77±0.64 and 0.97±0.52 respectively).
CONCLUSIONS: Improving cardiovascular health could prevent the onset of depression in the elderly. Diabetes and total cholesterol in individuals at high CVR, may play a specific role in the precise response. International Standard Randomized Controlled Trial (ISRCTN89898870).
| Medienart: |
E-Artikel |
|---|
| Erscheinungsjahr: |
2022 |
|---|---|
| Erschienen: |
2022 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:17 |
|---|---|
| Enthalten in: |
PloS one - 17(2022), 4 vom: 01., Seite e0265079 |
| Sprache: |
Englisch |
|---|
| Links: |
|---|
| Themen: |
97C5T2UQ7J |
|---|
| Anmerkungen: |
Date Completed 15.04.2022 Date Revised 15.06.2022 published: Electronic-eCollection ISRCTN: ISRCTN89898870 Citation Status MEDLINE |
|---|
| doi: |
10.1371/journal.pone.0265079 |
|---|
| funding: |
|
|---|---|
| Förderinstitution / Projekttitel: |
|
| PPN (Katalog-ID): |
NLM339469641 |
|---|
| LEADER | 01000naa a22002652 4500 | ||
|---|---|---|---|
| 001 | NLM339469641 | ||
| 003 | DE-627 | ||
| 005 | 20231226002951.0 | ||
| 007 | cr uuu---uuuuu | ||
| 008 | 231226s2022 xx |||||o 00| ||eng c | ||
| 024 | 7 | |a 10.1371/journal.pone.0265079 |2 doi | |
| 028 | 5 | 2 | |a pubmed24n1131.xml |
| 035 | |a (DE-627)NLM339469641 | ||
| 035 | |a (NLM)35417452 | ||
| 040 | |a DE-627 |b ger |c DE-627 |e rakwb | ||
| 041 | |a eng | ||
| 100 | 1 | |a Martín-Peláez, Sandra |e verfasserin |4 aut | |
| 245 | 1 | 0 | |a Contribution of cardio-vascular risk factors to depressive status in the PREDIMED-PLUS Trial. A cross-sectional and a 2-year longitudinal study |
| 264 | 1 | |c 2022 | |
| 336 | |a Text |b txt |2 rdacontent | ||
| 337 | |a ƒaComputermedien |b c |2 rdamedia | ||
| 338 | |a ƒa Online-Ressource |b cr |2 rdacarrier | ||
| 500 | |a Date Completed 15.04.2022 | ||
| 500 | |a Date Revised 15.06.2022 | ||
| 500 | |a published: Electronic-eCollection | ||
| 500 | |a ISRCTN: ISRCTN89898870 | ||
| 500 | |a Citation Status MEDLINE | ||
| 520 | |a BACKGROUND: Cardio-vascular disease and depression are thought to be closely related, due to shared risk factors. The aim of the study was to determine the association between cardio-vascular risk (CVR) factors and depressive status in a population (55-75 years) with metabolic syndrome (MetS) from the PREDIMED-Plus trial | ||
| 520 | |a METHODS AND FINDINGS: Participants were classified into three groups of CVR according to the Framingham-based REGICOR function: (1) low (LR), (2) medium (MR) or (3) high/very high (HR). The Beck Depression Inventory-II (BDI-II) was used to assess depressive symptoms at baseline and after 2 years. The association between CVR and depressive status at baseline (n = 6545), and their changes after 2 years (n = 4566) were evaluated through multivariable regression models (logistic and linear models). HR women showed higher odds of depressive status than LR [OR (95% CI) = 1.78 (1.26, 2.50)]. MR and HR participants with total cholesterol <160 mg/mL showed higher odds of depression than LR [OR (95% CI) = 1.77 (1.13, 2.77) and 2.83 (1.25, 6.42) respectively)] but those with total cholesterol ≥280 mg/mL showed lower odds of depression than LR [OR (95% CI) = 0.26 (0.07, 0.98) and 0.23 (0.05, 0.95), respectively]. All participants decreased their BDI-II score after 2 years, being the decrease smaller in MR and HR diabetic compared to LR [adjusted mean±SE = -0.52±0.20, -0.41±0.27 and -1.25±0.31 respectively). MR and HR participants with total cholesterol between 240-279 mg/mL showed greater decreases in the BDI-II score compared to LR (adjusted mean±SE = -0.83±0.37, -0.77±0.64 and 0.97±0.52 respectively) | ||
| 520 | |a CONCLUSIONS: Improving cardiovascular health could prevent the onset of depression in the elderly. Diabetes and total cholesterol in individuals at high CVR, may play a specific role in the precise response. International Standard Randomized Controlled Trial (ISRCTN89898870) | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a Research Support, Non-U.S. Gov't | |
| 650 | 7 | |a Cholesterol |2 NLM | |
| 650 | 7 | |a 97C5T2UQ7J |2 NLM | |
| 700 | 1 | |a Serra-Majem, Lluis |e verfasserin |4 aut | |
| 700 | 1 | |a Cano-Ibáñez, Naomi |e verfasserin |4 aut | |
| 700 | 1 | |a Martínez-González, Miguel Ángel |e verfasserin |4 aut | |
| 700 | 1 | |a Salas-Salvadó, Jordi |e verfasserin |4 aut | |
| 700 | 1 | |a Corella, Dolores |e verfasserin |4 aut | |
| 700 | 1 | |a Lassale, Camille |e verfasserin |4 aut | |
| 700 | 1 | |a Martínez, Jose Alfredo |e verfasserin |4 aut | |
| 700 | 1 | |a Alonso-Gómez, Ángel M |e verfasserin |4 aut | |
| 700 | 1 | |a Wärnberg, Julia |e verfasserin |4 aut | |
| 700 | 1 | |a Vioque, Jesús |e verfasserin |4 aut | |
| 700 | 1 | |a Romaguera, Dora |e verfasserin |4 aut | |
| 700 | 1 | |a López-Miranda, José |e verfasserin |4 aut | |
| 700 | 1 | |a Estruch, Ramón |e verfasserin |4 aut | |
| 700 | 1 | |a Tinahones, Francisco J |e verfasserin |4 aut | |
| 700 | 1 | |a Lapetra, José |e verfasserin |4 aut | |
| 700 | 1 | |a Fernández-Aranda, Fernando |e verfasserin |4 aut | |
| 700 | 1 | |a Bueno-Cavanillas, Aurora |e verfasserin |4 aut | |
| 700 | 1 | |a Tur, Josep A |e verfasserin |4 aut | |
| 700 | 1 | |a Martín, Vicente |e verfasserin |4 aut | |
| 700 | 1 | |a Pintó, Xavier |e verfasserin |4 aut | |
| 700 | 1 | |a Delgado-Rodríguez, Miguel |e verfasserin |4 aut | |
| 700 | 1 | |a Matía, Pilar |e verfasserin |4 aut | |
| 700 | 1 | |a Vidal, Josep |e verfasserin |4 aut | |
| 700 | 1 | |a Vázquez, Clotilde |e verfasserin |4 aut | |
| 700 | 1 | |a Daimiel, Lidia |e verfasserin |4 aut | |
| 700 | 1 | |a Ros, Emili |e verfasserin |4 aut | |
| 700 | 1 | |a Toledo, Estefanía |e verfasserin |4 aut | |
| 700 | 1 | |a Nishi, Stephanie K |e verfasserin |4 aut | |
| 700 | 1 | |a Sorli, Jose V |e verfasserin |4 aut | |
| 700 | 1 | |a Malcampo, Mireia |e verfasserin |4 aut | |
| 700 | 1 | |a Zulet, M Ángeles |e verfasserin |4 aut | |
| 700 | 1 | |a Moreno-Rodríguez, Anaí |e verfasserin |4 aut | |
| 700 | 1 | |a Cueto-Galán, Raquel |e verfasserin |4 aut | |
| 700 | 1 | |a Vivancos-Aparicio, Diego |e verfasserin |4 aut | |
| 700 | 1 | |a Colom, Antoni |e verfasserin |4 aut | |
| 700 | 1 | |a García-Ríos, Antonio |e verfasserin |4 aut | |
| 700 | 1 | |a Casas, Rosa |e verfasserin |4 aut | |
| 700 | 1 | |a Bernal-López, M Rosa |e verfasserin |4 aut | |
| 700 | 1 | |a Santos-Lozano, Jose Manuel |e verfasserin |4 aut | |
| 700 | 1 | |a Vázquez, Zenaida |e verfasserin |4 aut | |
| 700 | 1 | |a Gómez-Martínez, Carlos |e verfasserin |4 aut | |
| 700 | 1 | |a Ortega-Azorín, Carolina |e verfasserin |4 aut | |
| 700 | 1 | |a Del Val, Jose Luís |e verfasserin |4 aut | |
| 700 | 1 | |a Abete, Itziar |e verfasserin |4 aut | |
| 700 | 1 | |a Goikoetxea-Bahon, Amaia |e verfasserin |4 aut | |
| 700 | 1 | |a Pascual, Elena |e verfasserin |4 aut | |
| 700 | 1 | |a Becerra-Tomás, Nerea |e verfasserin |4 aut | |
| 700 | 1 | |a Chillarón, Juan J |e verfasserin |4 aut | |
| 700 | 1 | |a Sánchez-Villegas, Almudena |e verfasserin |4 aut | |
| 773 | 0 | 8 | |i Enthalten in |t PloS one |d 2006 |g 17(2022), 4 vom: 01., Seite e0265079 |w (DE-627)NLM167327399 |x 1932-6203 |7 nnns |
| 773 | 1 | 8 | |g volume:17 |g year:2022 |g number:4 |g day:01 |g pages:e0265079 |
| 856 | 4 | 0 | |u http://dx.doi.org/10.1371/journal.pone.0265079 |3 Volltext |
| 912 | |a GBV_USEFLAG_A | ||
| 912 | |a GBV_NLM | ||
| 951 | |a AR | ||
| 952 | |d 17 |j 2022 |e 4 |b 01 |h e0265079 | ||