Appropriateness of antibiotic prescriptions during hospitalization and ambulatory care : a multicentre prevalence survey in Korea
Copyright © 2022 The Author(s). Published by Elsevier Ltd.. All rights reserved..
OBJECTIVES: Antimicrobial resistance is one of the most urgent global health threats. The need for the qualitative evaluation of antibiotic use at the national level is increasing. To identify areas for improvement, we aimed to assess the prevalence and appropriateness of antibiotic prescriptions during hospitalization and ambulatory care in Korea.
METHODS: The prevalence and appropriateness of antibiotic prescriptions on 29 August 2018 were assessed for 20 hospitals in Korea. Infectious disease specialists determined appropriateness. Except for antiviral and anti-tuberculosis agents, all antibacterial or antifungal agent prescriptions during hospitalization or ambulatory care were evaluated.
RESULTS: The prevalence of antibiotic prescription was 14.1% (8,400/59 216 patients) on the study date. Antibiotics were prescribed for 50.8% of inpatients (6557/12 902), with two or more antibiotics prescribed for 27.4% (1798/6557) of patients. A total of 10 948 prescriptions (7999 therapeutic, 2105 surgical prophylaxes, and 844 medical prophylaxes) were included in the final analysis, and 27.7% of these were inappropriate. Surgical prophylaxis was inadequately prescribed most frequently (54.4%), followed by medical prophylaxis (29.5%) and therapeutic antibiotics (20.5%). The most common indications for therapeutic antibiotics were respiratory (29.1%, n=2332), gastrointestinal (22.4%, n=1791), and urinary tract infections (13.1%, n=1050). The most frequently prescribed antibiotics were cephalosporins (52.0%, n=5490), followed by beta lactam/beta lactamase inhibitors (13.7%, n=1373), fluoroquinolones (9.1%, n=957), and metronidazole (6.6%, n=699).
CONCLUSION: This was the first nationwide qualitative antibiotic prescription adequacy evaluation in Korea. A significant proportion of antibiotic prescriptions were inappropriate. Therefore, interventions for high-frequency infections and prescription antibiotics are needed.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2022 |
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| Erschienen: |
2022 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:29 |
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| Enthalten in: |
Journal of global antimicrobial resistance - 29(2022) vom: 15. Juni, Seite 253-258 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Park, Se Yoon [VerfasserIn] |
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| Links: |
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| Anmerkungen: |
Date Completed 21.06.2022 Date Revised 03.10.2022 published: Print-Electronic Citation Status MEDLINE |
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| doi: |
10.1016/j.jgar.2022.03.021 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM339429933 |
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| 024 | 7 | |a 10.1016/j.jgar.2022.03.021 |2 doi | |
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| 041 | |a eng | ||
| 100 | 1 | |a Park, Se Yoon |e verfasserin |4 aut | |
| 245 | 1 | 0 | |a Appropriateness of antibiotic prescriptions during hospitalization and ambulatory care |b a multicentre prevalence survey in Korea |
| 264 | 1 | |c 2022 | |
| 336 | |a Text |b txt |2 rdacontent | ||
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| 500 | |a Date Completed 21.06.2022 | ||
| 500 | |a Date Revised 03.10.2022 | ||
| 500 | |a published: Print-Electronic | ||
| 500 | |a Citation Status MEDLINE | ||
| 520 | |a Copyright © 2022 The Author(s). Published by Elsevier Ltd.. All rights reserved. | ||
| 520 | |a OBJECTIVES: Antimicrobial resistance is one of the most urgent global health threats. The need for the qualitative evaluation of antibiotic use at the national level is increasing. To identify areas for improvement, we aimed to assess the prevalence and appropriateness of antibiotic prescriptions during hospitalization and ambulatory care in Korea | ||
| 520 | |a METHODS: The prevalence and appropriateness of antibiotic prescriptions on 29 August 2018 were assessed for 20 hospitals in Korea. Infectious disease specialists determined appropriateness. Except for antiviral and anti-tuberculosis agents, all antibacterial or antifungal agent prescriptions during hospitalization or ambulatory care were evaluated | ||
| 520 | |a RESULTS: The prevalence of antibiotic prescription was 14.1% (8,400/59 216 patients) on the study date. Antibiotics were prescribed for 50.8% of inpatients (6557/12 902), with two or more antibiotics prescribed for 27.4% (1798/6557) of patients. A total of 10 948 prescriptions (7999 therapeutic, 2105 surgical prophylaxes, and 844 medical prophylaxes) were included in the final analysis, and 27.7% of these were inappropriate. Surgical prophylaxis was inadequately prescribed most frequently (54.4%), followed by medical prophylaxis (29.5%) and therapeutic antibiotics (20.5%). The most common indications for therapeutic antibiotics were respiratory (29.1%, n=2332), gastrointestinal (22.4%, n=1791), and urinary tract infections (13.1%, n=1050). The most frequently prescribed antibiotics were cephalosporins (52.0%, n=5490), followed by beta lactam/beta lactamase inhibitors (13.7%, n=1373), fluoroquinolones (9.1%, n=957), and metronidazole (6.6%, n=699) | ||
| 520 | |a CONCLUSION: This was the first nationwide qualitative antibiotic prescription adequacy evaluation in Korea. A significant proportion of antibiotic prescriptions were inappropriate. Therefore, interventions for high-frequency infections and prescription antibiotics are needed | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a Multicenter Study | |
| 650 | 4 | |a Research Support, Non-U.S. Gov't | |
| 650 | 4 | |a Anti-bacterial agents | |
| 650 | 4 | |a Antibiotic prophylaxis | |
| 650 | 4 | |a Appropriateness | |
| 650 | 4 | |a Bacterial infection | |
| 650 | 4 | |a Point prevalence survey | |
| 650 | 7 | |a Anti-Bacterial Agents |2 NLM | |
| 650 | 7 | |a beta-Lactamase Inhibitors |2 NLM | |
| 700 | 1 | |a Moon, Song Mi |e verfasserin |4 aut | |
| 700 | 1 | |a Kim, Bongyoung |e verfasserin |4 aut | |
| 700 | 1 | |a Lee, Myung Jin |e verfasserin |4 aut | |
| 700 | 1 | |a Park, Ji Young |e verfasserin |4 aut | |
| 700 | 1 | |a Hwang, Soyoon |e verfasserin |4 aut | |
| 700 | 1 | |a Yu, Shi Nae |e verfasserin |4 aut | |
| 700 | 1 | |a Lee, Yu-Mi |e verfasserin |4 aut | |
| 700 | 1 | |a Lee, Ho Jin |e verfasserin |4 aut | |
| 700 | 1 | |a Hong, Kyung-Wook |e verfasserin |4 aut | |
| 700 | 1 | |a Park, Kyung-Hwa |e verfasserin |4 aut | |
| 700 | 1 | |a Kwak, Yee Gyung |e verfasserin |4 aut | |
| 700 | 1 | |a Moon, Chisook |e verfasserin |4 aut | |
| 700 | 1 | |a Jeon, Min Hyok |e verfasserin |4 aut | |
| 700 | 1 | |a Park, Sun Hee |e verfasserin |4 aut | |
| 700 | 1 | |a Kim, Young Keun |e verfasserin |4 aut | |
| 700 | 1 | |a Song, Kyoung-Ho |e verfasserin |4 aut | |
| 700 | 1 | |a Kim, Eu Suk |e verfasserin |4 aut | |
| 700 | 1 | |a Kim, Tae Hyong |e verfasserin |4 aut | |
| 700 | 1 | |a Kim, Hong Bin |e verfasserin |4 aut | |
| 700 | 0 | |a Korea Study Group for Antimicrobial Stewardship (KOSGAP) |e verfasserin |4 aut | |
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