Cross-sectional diagnostic accuracy study of self-testing for proteinuria during hypertensive pregnancies : The UDIP study
© 2022 The Authors. BJOG: An International Journal of Obstetrics and Gynaecology published by John Wiley & Sons Ltd..
OBJECTIVE: To determine the accuracy of self-testing for proteinuria during pregnancy.
DESIGN: Diagnostic accuracy study.
SETTING: Antenatal clinics, maternity assessment units and inpatient wards at three hospital sites.
POPULATION OR SAMPLE: 345 pregnant women.
METHODS: Pregnant women self-tested in-clinic for urinary protein using visually read dipsticks with samples then sent for laboratory estimation of the spot protein-creatinine ratio (PCR) (primary reference test). Secondary index tests included testing by antenatal healthcare professionals and an automated colorimetric reader.
MAIN OUTCOME MEASURES: Sensitivity, specificity, negative predictive value, positive predictive value and likelihood ratios were calculated for self-testing (primary index test) along with healthcare professional and colorimetric testing compared to the primary reference test (PCR).
RESULTS: 335/345 (97%) had sufficient data to be included in the analysis. Self-testing had a sensitivity of 0.71 (95% confidence interval [CI] 0.62-0.79) and a specificity of 0.89 (95% CI 0.84-0.92) compared to PCR. Sensitivity and specificity of testing by healthcare professionals and the colorimetric reader were similar: sensitivity 0.73 (95% CI 0.64-0.80) and 0.78 (95% CI 0.69-0.85), respectively; specificity 0.88 (95% CI 0.82-0.92) and 0.83 (95% CI 0.78-0.88), respectively.
CONCLUSION: Pregnant women can visually read a dipstick for urinary protein with similar accuracy to antenatal healthcare professionals. Automated colorimetric testing was not significantly different, in contrast to some previous studies. Self-testing has the potential to form part of a self-monitoring regime in pregnancy.
| Errataetall: | |
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| Medienart: |
E-Artikel |
| Erscheinungsjahr: |
2022 |
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| Erschienen: |
2022 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:129 |
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| Enthalten in: |
BJOG : an international journal of obstetrics and gynaecology - 129(2022), 13 vom: 01. Dez., Seite 2142-2148 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Jakubowski, Bethany Ellen [VerfasserIn] |
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| Links: |
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| Themen: |
Diagnostic accuracy study |
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| Anmerkungen: |
Date Completed 08.11.2022 Date Revised 29.12.2022 published: Print-Electronic CommentIn: BJOG. 2022 Dec;129(13):2149. - PMID 35491740 Citation Status MEDLINE |
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| doi: |
10.1111/1471-0528.17180 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM339422459 |
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| 100 | 1 | |a Jakubowski, Bethany Ellen |e verfasserin |4 aut | |
| 245 | 1 | 0 | |a Cross-sectional diagnostic accuracy study of self-testing for proteinuria during hypertensive pregnancies |b The UDIP study |
| 264 | 1 | |c 2022 | |
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| 500 | |a Date Completed 08.11.2022 | ||
| 500 | |a Date Revised 29.12.2022 | ||
| 500 | |a published: Print-Electronic | ||
| 500 | |a CommentIn: BJOG. 2022 Dec;129(13):2149. - PMID 35491740 | ||
| 500 | |a Citation Status MEDLINE | ||
| 520 | |a © 2022 The Authors. BJOG: An International Journal of Obstetrics and Gynaecology published by John Wiley & Sons Ltd. | ||
| 520 | |a OBJECTIVE: To determine the accuracy of self-testing for proteinuria during pregnancy | ||
| 520 | |a DESIGN: Diagnostic accuracy study | ||
| 520 | |a SETTING: Antenatal clinics, maternity assessment units and inpatient wards at three hospital sites | ||
| 520 | |a POPULATION OR SAMPLE: 345 pregnant women | ||
| 520 | |a METHODS: Pregnant women self-tested in-clinic for urinary protein using visually read dipsticks with samples then sent for laboratory estimation of the spot protein-creatinine ratio (PCR) (primary reference test). Secondary index tests included testing by antenatal healthcare professionals and an automated colorimetric reader | ||
| 520 | |a MAIN OUTCOME MEASURES: Sensitivity, specificity, negative predictive value, positive predictive value and likelihood ratios were calculated for self-testing (primary index test) along with healthcare professional and colorimetric testing compared to the primary reference test (PCR) | ||
| 520 | |a RESULTS: 335/345 (97%) had sufficient data to be included in the analysis. Self-testing had a sensitivity of 0.71 (95% confidence interval [CI] 0.62-0.79) and a specificity of 0.89 (95% CI 0.84-0.92) compared to PCR. Sensitivity and specificity of testing by healthcare professionals and the colorimetric reader were similar: sensitivity 0.73 (95% CI 0.64-0.80) and 0.78 (95% CI 0.69-0.85), respectively; specificity 0.88 (95% CI 0.82-0.92) and 0.83 (95% CI 0.78-0.88), respectively | ||
| 520 | |a CONCLUSION: Pregnant women can visually read a dipstick for urinary protein with similar accuracy to antenatal healthcare professionals. Automated colorimetric testing was not significantly different, in contrast to some previous studies. Self-testing has the potential to form part of a self-monitoring regime in pregnancy | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a diagnostic accuracy study | |
| 650 | 4 | |a hypertension | |
| 650 | 4 | |a pre-eclampsia | |
| 650 | 4 | |a pregnancy | |
| 650 | 4 | |a proteinuria | |
| 650 | 4 | |a self-testing | |
| 700 | 1 | |a Stevens, Richard |e verfasserin |4 aut | |
| 700 | 1 | |a Wilson, Hannah |e verfasserin |4 aut | |
| 700 | 1 | |a Lavallee, Layla |e verfasserin |4 aut | |
| 700 | 1 | |a Brittain, Lesley |e verfasserin |4 aut | |
| 700 | 1 | |a Crawford, Carole |e verfasserin |4 aut | |
| 700 | 1 | |a Hodgkinson, James |e verfasserin |4 aut | |
| 700 | 1 | |a Hinton, Lisa |e verfasserin |4 aut | |
| 700 | 1 | |a Mackillop, Lucy |e verfasserin |4 aut | |
| 700 | 1 | |a Chappell, Lucy C |e verfasserin |4 aut | |
| 700 | 1 | |a McManus, Richard J |e verfasserin |4 aut | |
| 700 | 1 | |a Tucker, Katherine Louise |e verfasserin |4 aut | |
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