Differences Between Plasma and Cerebrospinal Fluid p-tau181 and p-tau231 in Early Alzheimer's Disease
Plasma phosphorylated tau species have been recently proposed as peripheral markers of Alzheimer's disease (AD) pathology. In this cross-sectional study including 91 subjects, plasma and cerebrospinal fluid (CSF) p-tau181 and p-tau231 levels were elevated in the early symptomatic stages of AD. Plasma p-tau231 and p-tau181 were strongly related to CSF phosphorylated tau, total tau and amyloid and exhibited a high accuracy-close to CSF p-tau231 and p-tau181-to identify AD already in the early stage of the disease. The findings might support the use as diagnostic and prognostic peripheral AD biomarkers in both research and clinical settings.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2022 |
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| Erschienen: |
2022 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:87 |
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| Enthalten in: |
Journal of Alzheimer's disease : JAD - 87(2022), 3 vom: 11., Seite 991-997 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Pilotto, Andrea [VerfasserIn] |
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| Links: |
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| Themen: |
Alzheimer’s disease |
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| Anmerkungen: |
Date Completed 08.06.2022 Date Revised 22.07.2022 published: Print Citation Status MEDLINE |
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| doi: |
10.3233/JAD-215646 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM339339004 |
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| 500 | |a Date Revised 22.07.2022 | ||
| 500 | |a published: Print | ||
| 500 | |a Citation Status MEDLINE | ||
| 520 | |a Plasma phosphorylated tau species have been recently proposed as peripheral markers of Alzheimer's disease (AD) pathology. In this cross-sectional study including 91 subjects, plasma and cerebrospinal fluid (CSF) p-tau181 and p-tau231 levels were elevated in the early symptomatic stages of AD. Plasma p-tau231 and p-tau181 were strongly related to CSF phosphorylated tau, total tau and amyloid and exhibited a high accuracy-close to CSF p-tau231 and p-tau181-to identify AD already in the early stage of the disease. The findings might support the use as diagnostic and prognostic peripheral AD biomarkers in both research and clinical settings | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a Research Support, Non-U.S. Gov't | |
| 650 | 4 | |a Alzheimer’s disease | |
| 650 | 4 | |a cerebrospinal fluid | |
| 650 | 4 | |a phosphorylated-tau | |
| 650 | 4 | |a plasma biomarkers | |
| 650 | 7 | |a Amyloid beta-Peptides |2 NLM | |
| 650 | 7 | |a Biomarkers |2 NLM | |
| 650 | 7 | |a tau Proteins |2 NLM | |
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| 700 | 1 | |a Bonzi, Giulio |e verfasserin |4 aut | |
| 700 | 1 | |a Battaglio, Beatrice |e verfasserin |4 aut | |
| 700 | 1 | |a Ferrari, Elisabetta |e verfasserin |4 aut | |
| 700 | 1 | |a Mensi, Lorenza |e verfasserin |4 aut | |
| 700 | 1 | |a Benussi, Alberto |e verfasserin |4 aut | |
| 700 | 1 | |a Caratozzolo, Salvatore |e verfasserin |4 aut | |
| 700 | 1 | |a Cosseddu, Maura |e verfasserin |4 aut | |
| 700 | 1 | |a Turrone, Rosanna |e verfasserin |4 aut | |
| 700 | 1 | |a Archetti, Silvana |e verfasserin |4 aut | |
| 700 | 1 | |a Ashton, Nicholas J |e verfasserin |4 aut | |
| 700 | 1 | |a Zetterberg, Henrik |e verfasserin |4 aut | |
| 700 | 1 | |a Giliani, Silvia |e verfasserin |4 aut | |
| 700 | 1 | |a Padovani, Alessandro |e verfasserin |4 aut | |
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