Reference materials for MS-based untargeted metabolomics and lipidomics : a review by the metabolomics quality assurance and quality control consortium (mQACC)
© 2022. This is a U.S. government work and not under copyright protection in the U.S.; foreign copyright protection may apply..
INTRODUCTION: The metabolomics quality assurance and quality control consortium (mQACC) is enabling the identification, development, prioritization, and promotion of suitable reference materials (RMs) to be used in quality assurance (QA) and quality control (QC) for untargeted metabolomics research.
OBJECTIVES: This review aims to highlight current RMs, and methodologies used within untargeted metabolomics and lipidomics communities to ensure standardization of results obtained from data analysis, interpretation and cross-study, and cross-laboratory comparisons. The essence of the aims is also applicable to other 'omics areas that generate high dimensional data.
RESULTS: The potential for game-changing biochemical discoveries through mass spectrometry-based (MS) untargeted metabolomics and lipidomics are predicated on the evolution of more confident qualitative (and eventually quantitative) results from research laboratories. RMs are thus critical QC tools to be able to assure standardization, comparability, repeatability and reproducibility for untargeted data analysis, interpretation, to compare data within and across studies and across multiple laboratories. Standard operating procedures (SOPs) that promote, describe and exemplify the use of RMs will also improve QC for the metabolomics and lipidomics communities.
CONCLUSIONS: The application of RMs described in this review may significantly improve data quality to support metabolomics and lipidomics research. The continued development and deployment of new RMs, together with interlaboratory studies and educational outreach and training, will further promote sound QA practices in the community.
| Medienart: |
E-Artikel |
|---|
| Erscheinungsjahr: |
2022 |
|---|---|
| Erschienen: |
2022 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:18 |
|---|---|
| Enthalten in: |
Metabolomics : Official journal of the Metabolomic Society - 18(2022), 4 vom: 09. Apr., Seite 24 |
| Sprache: |
Englisch |
|---|
| Beteiligte Personen: |
Lippa, Katrice A [VerfasserIn] |
|---|
| Links: |
|---|
| Anmerkungen: |
Date Completed 12.04.2022 Date Revised 16.07.2022 published: Electronic Citation Status MEDLINE |
|---|
| doi: |
10.1007/s11306-021-01848-6 |
|---|
| funding: |
|
|---|---|
| Förderinstitution / Projekttitel: |
|
| PPN (Katalog-ID): |
NLM339266589 |
|---|
| LEADER | 01000naa a22002652 4500 | ||
|---|---|---|---|
| 001 | NLM339266589 | ||
| 003 | DE-627 | ||
| 005 | 20231226002518.0 | ||
| 007 | cr uuu---uuuuu | ||
| 008 | 231226s2022 xx |||||o 00| ||eng c | ||
| 024 | 7 | |a 10.1007/s11306-021-01848-6 |2 doi | |
| 028 | 5 | 2 | |a pubmed24n1130.xml |
| 035 | |a (DE-627)NLM339266589 | ||
| 035 | |a (NLM)35397018 | ||
| 040 | |a DE-627 |b ger |c DE-627 |e rakwb | ||
| 041 | |a eng | ||
| 100 | 1 | |a Lippa, Katrice A |e verfasserin |4 aut | |
| 245 | 1 | 0 | |a Reference materials for MS-based untargeted metabolomics and lipidomics |b a review by the metabolomics quality assurance and quality control consortium (mQACC) |
| 264 | 1 | |c 2022 | |
| 336 | |a Text |b txt |2 rdacontent | ||
| 337 | |a ƒaComputermedien |b c |2 rdamedia | ||
| 338 | |a ƒa Online-Ressource |b cr |2 rdacarrier | ||
| 500 | |a Date Completed 12.04.2022 | ||
| 500 | |a Date Revised 16.07.2022 | ||
| 500 | |a published: Electronic | ||
| 500 | |a Citation Status MEDLINE | ||
| 520 | |a © 2022. This is a U.S. government work and not under copyright protection in the U.S.; foreign copyright protection may apply. | ||
| 520 | |a INTRODUCTION: The metabolomics quality assurance and quality control consortium (mQACC) is enabling the identification, development, prioritization, and promotion of suitable reference materials (RMs) to be used in quality assurance (QA) and quality control (QC) for untargeted metabolomics research | ||
| 520 | |a OBJECTIVES: This review aims to highlight current RMs, and methodologies used within untargeted metabolomics and lipidomics communities to ensure standardization of results obtained from data analysis, interpretation and cross-study, and cross-laboratory comparisons. The essence of the aims is also applicable to other 'omics areas that generate high dimensional data | ||
| 520 | |a RESULTS: The potential for game-changing biochemical discoveries through mass spectrometry-based (MS) untargeted metabolomics and lipidomics are predicated on the evolution of more confident qualitative (and eventually quantitative) results from research laboratories. RMs are thus critical QC tools to be able to assure standardization, comparability, repeatability and reproducibility for untargeted data analysis, interpretation, to compare data within and across studies and across multiple laboratories. Standard operating procedures (SOPs) that promote, describe and exemplify the use of RMs will also improve QC for the metabolomics and lipidomics communities | ||
| 520 | |a CONCLUSIONS: The application of RMs described in this review may significantly improve data quality to support metabolomics and lipidomics research. The continued development and deployment of new RMs, together with interlaboratory studies and educational outreach and training, will further promote sound QA practices in the community | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a Review | |
| 650 | 4 | |a Certified reference materials | |
| 650 | 4 | |a Internal standards | |
| 650 | 4 | |a Lipidomics | |
| 650 | 4 | |a Mass spectrometry | |
| 650 | 4 | |a Metabolomics | |
| 650 | 4 | |a Metabolomics quality assurance and quality control consortium (mQACC) | |
| 650 | 4 | |a Reference materials | |
| 650 | 4 | |a Untargeted analysis | |
| 700 | 1 | |a Aristizabal-Henao, Juan J |e verfasserin |4 aut | |
| 700 | 1 | |a Beger, Richard D |e verfasserin |4 aut | |
| 700 | 1 | |a Bowden, John A |e verfasserin |4 aut | |
| 700 | 1 | |a Broeckling, Corey |e verfasserin |4 aut | |
| 700 | 1 | |a Beecher, Chris |e verfasserin |4 aut | |
| 700 | 1 | |a Clay Davis, W |e verfasserin |4 aut | |
| 700 | 1 | |a Dunn, Warwick B |e verfasserin |4 aut | |
| 700 | 1 | |a Flores, Roberto |e verfasserin |4 aut | |
| 700 | 1 | |a Goodacre, Royston |e verfasserin |4 aut | |
| 700 | 1 | |a Gouveia, Gonçalo J |e verfasserin |4 aut | |
| 700 | 1 | |a Harms, Amy C |e verfasserin |4 aut | |
| 700 | 1 | |a Hartung, Thomas |e verfasserin |4 aut | |
| 700 | 1 | |a Jones, Christina M |e verfasserin |4 aut | |
| 700 | 1 | |a Lewis, Matthew R |e verfasserin |4 aut | |
| 700 | 1 | |a Ntai, Ioanna |e verfasserin |4 aut | |
| 700 | 1 | |a Percy, Andrew J |e verfasserin |4 aut | |
| 700 | 1 | |a Raftery, Dan |e verfasserin |4 aut | |
| 700 | 1 | |a Schock, Tracey B |e verfasserin |4 aut | |
| 700 | 1 | |a Sun, Jinchun |e verfasserin |4 aut | |
| 700 | 1 | |a Theodoridis, Georgios |e verfasserin |4 aut | |
| 700 | 1 | |a Tayyari, Fariba |e verfasserin |4 aut | |
| 700 | 1 | |a Torta, Federico |e verfasserin |4 aut | |
| 700 | 1 | |a Ulmer, Candice Z |e verfasserin |4 aut | |
| 700 | 1 | |a Wilson, Ian |e verfasserin |4 aut | |
| 700 | 1 | |a Ubhi, Baljit K |e verfasserin |4 aut | |
| 773 | 0 | 8 | |i Enthalten in |t Metabolomics : Official journal of the Metabolomic Society |d 2005 |g 18(2022), 4 vom: 09. Apr., Seite 24 |w (DE-627)NLM162625987 |x 1573-3890 |7 nnns |
| 773 | 1 | 8 | |g volume:18 |g year:2022 |g number:4 |g day:09 |g month:04 |g pages:24 |
| 856 | 4 | 0 | |u http://dx.doi.org/10.1007/s11306-021-01848-6 |3 Volltext |
| 912 | |a GBV_USEFLAG_A | ||
| 912 | |a GBV_NLM | ||
| 951 | |a AR | ||
| 952 | |d 18 |j 2022 |e 4 |b 09 |c 04 |h 24 | ||