The feasibility of baroreflex sensitivity measurements in heart failure subjects : The role of slow-patterned breathing
© 2022 Scandinavian Society of Clinical Physiology and Nuclear Medicine..
INTRODUCTION: Increased muscle sympathetic nerve activity (MSNA) indicates an adverse outcome in heart failure. Decreased baroreflex modulation of MSNA is a well-known feature of the disease. The determinability of cardiovagal baroreflex sensitivity (BRS) in heart failure is low, however, the determinability of sympathetic BRS is not known.
METHODS: We have assessed the spontaneous, MSNA burst incidence-based baroreflex index (BRSsymp) in 33 stable heart failure patients and in 10 healthy controls using the traditional r ≥ .5 cutoff for acceptable individual diastolic pressure-burst incidence slopes, and also a more stringent r ≥ .7 cutoff. We have also assessed the influence of 6/min breathing.
RESULTS: The determinability of BRSsymp in heart failure patients was 64% during spontaneous breathing with r ≥ .5 cutoff, and 39% using the r ≥ .7 cutoff. The determinability of these indices further decreased during 6/min breathing, dropping to 29% with the r ≥ .7 cutoff. In contrast, the determinability of the cardiovagal BRS indices increased significantly with 6/min breathing (from 24% to 66%; p < .001). Patients who still had determinable BRSsymp at the r ≥ .7 cutoff had a significantly lower baseline burst incidence than those with an undeterminable index (70 ± 14 vs. 89 ± 10 burst/100 cycles; p < .002). Neither the 6/min breathing, nor the r ≥ .7 cutoff limit influenced the high availability of BRSsymp in healthy subjects.
CONCLUSION: The determinability of BRSsymp in heart failure patients is limited, especially with the 0.7 limit for correlation. Undeterminable BRSsymp in patients is associated with higher sympathetic activity. 6/min breathing improves the determinability of cardiovagal BRS indices, but not that of BRSsymp.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2022 |
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| Erschienen: |
2022 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:42 |
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| Enthalten in: |
Clinical physiology and functional imaging - 42(2022), 4 vom: 01. Juli, Seite 260-268 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Urbancsek, Réka [VerfasserIn] |
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| Links: |
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| Themen: |
Baroreflex gain |
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| Anmerkungen: |
Date Completed 09.06.2022 Date Revised 09.06.2022 published: Print-Electronic Citation Status MEDLINE |
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| doi: |
10.1111/cpf.12755 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM339265469 |
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| 100 | 1 | |a Urbancsek, Réka |e verfasserin |4 aut | |
| 245 | 1 | 4 | |a The feasibility of baroreflex sensitivity measurements in heart failure subjects |b The role of slow-patterned breathing |
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| 500 | |a Date Revised 09.06.2022 | ||
| 500 | |a published: Print-Electronic | ||
| 500 | |a Citation Status MEDLINE | ||
| 520 | |a © 2022 Scandinavian Society of Clinical Physiology and Nuclear Medicine. | ||
| 520 | |a INTRODUCTION: Increased muscle sympathetic nerve activity (MSNA) indicates an adverse outcome in heart failure. Decreased baroreflex modulation of MSNA is a well-known feature of the disease. The determinability of cardiovagal baroreflex sensitivity (BRS) in heart failure is low, however, the determinability of sympathetic BRS is not known | ||
| 520 | |a METHODS: We have assessed the spontaneous, MSNA burst incidence-based baroreflex index (BRSsymp) in 33 stable heart failure patients and in 10 healthy controls using the traditional r ≥ .5 cutoff for acceptable individual diastolic pressure-burst incidence slopes, and also a more stringent r ≥ .7 cutoff. We have also assessed the influence of 6/min breathing | ||
| 520 | |a RESULTS: The determinability of BRSsymp in heart failure patients was 64% during spontaneous breathing with r ≥ .5 cutoff, and 39% using the r ≥ .7 cutoff. The determinability of these indices further decreased during 6/min breathing, dropping to 29% with the r ≥ .7 cutoff. In contrast, the determinability of the cardiovagal BRS indices increased significantly with 6/min breathing (from 24% to 66%; p < .001). Patients who still had determinable BRSsymp at the r ≥ .7 cutoff had a significantly lower baseline burst incidence than those with an undeterminable index (70 ± 14 vs. 89 ± 10 burst/100 cycles; p < .002). Neither the 6/min breathing, nor the r ≥ .7 cutoff limit influenced the high availability of BRSsymp in healthy subjects | ||
| 520 | |a CONCLUSION: The determinability of BRSsymp in heart failure patients is limited, especially with the 0.7 limit for correlation. Undeterminable BRSsymp in patients is associated with higher sympathetic activity. 6/min breathing improves the determinability of cardiovagal BRS indices, but not that of BRSsymp | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a baroreflex gain | |
| 650 | 4 | |a heart failure | |
| 650 | 4 | |a muscle sympathetic nerve activity | |
| 650 | 4 | |a slow breathing | |
| 700 | 1 | |a Csanádi, Zoltán |e verfasserin |4 aut | |
| 700 | 1 | |a Forgács, Ildikó N |e verfasserin |4 aut | |
| 700 | 1 | |a Papp, Tímea B |e verfasserin |4 aut | |
| 700 | 1 | |a Boczán, Judit |e verfasserin |4 aut | |
| 700 | 1 | |a Barta, Judit |e verfasserin |4 aut | |
| 700 | 1 | |a Jenei, Csaba |e verfasserin |4 aut | |
| 700 | 1 | |a Nagy, László |e verfasserin |4 aut | |
| 700 | 1 | |a Rudas, László |e verfasserin |4 aut | |
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