Risk factors of first recurrence of Clostridioides difficile infection
Copyright © 2022 Elsevier Ltd. All rights reserved..
OBJECTIVES: Clostridioides difficile infection (CDI) often recurs. Approximately 25% of patients have recurrences after the initial treatment, and patients who have relapsed once are more likely to relapse. We aimed to identify the risk factors for initial CDI recurrence.
METHODS: We performed a retrospective survey of patient backgrounds and treatment-related factors. Risk factors were analyzed using single and multiple logistic regression analyses.
RESULTS: A total of 134 patients were included in the study. Prophylactic probiotic use and nasogastric tube feeding were independent risk factors for the initial recurrence of CDI. Patients using prophylactic probiotics had significantly higher recurrence rates than those not using prophylactic probiotics.
CONCLUSION: Prophylactic probiotic use and nasogastric tube placement may be risk factors for the initial recurrence of CDI. It is noteworthy that CDI that occurs during the use of prophylactic probiotics may be prone to recurrence.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2022 |
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| Erschienen: |
2022 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:75 |
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| Enthalten in: |
Anaerobe - 75(2022) vom: 15. Juni, Seite 102556 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Yokoyama, Yuki [VerfasserIn] |
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| Links: |
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| Themen: |
Clostridioides difficile |
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| Anmerkungen: |
Date Completed 14.06.2022 Date Revised 14.06.2022 published: Print-Electronic Citation Status MEDLINE |
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| doi: |
10.1016/j.anaerobe.2022.102556 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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NLM339250682 |
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| 500 | |a Date Revised 14.06.2022 | ||
| 500 | |a published: Print-Electronic | ||
| 500 | |a Citation Status MEDLINE | ||
| 520 | |a Copyright © 2022 Elsevier Ltd. All rights reserved. | ||
| 520 | |a OBJECTIVES: Clostridioides difficile infection (CDI) often recurs. Approximately 25% of patients have recurrences after the initial treatment, and patients who have relapsed once are more likely to relapse. We aimed to identify the risk factors for initial CDI recurrence | ||
| 520 | |a METHODS: We performed a retrospective survey of patient backgrounds and treatment-related factors. Risk factors were analyzed using single and multiple logistic regression analyses | ||
| 520 | |a RESULTS: A total of 134 patients were included in the study. Prophylactic probiotic use and nasogastric tube feeding were independent risk factors for the initial recurrence of CDI. Patients using prophylactic probiotics had significantly higher recurrence rates than those not using prophylactic probiotics | ||
| 520 | |a CONCLUSION: Prophylactic probiotic use and nasogastric tube placement may be risk factors for the initial recurrence of CDI. It is noteworthy that CDI that occurs during the use of prophylactic probiotics may be prone to recurrence | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a Clostridioides difficile | |
| 650 | 4 | |a Nasogastric (NG) tube | |
| 650 | 4 | |a Probiotics | |
| 650 | 4 | |a Recurrence | |
| 650 | 4 | |a Risk factor | |
| 700 | 1 | |a Shiota, Arufumi |e verfasserin |4 aut | |
| 700 | 1 | |a Asai, Nobuhiro |e verfasserin |4 aut | |
| 700 | 1 | |a Koizumi, Yusuke |e verfasserin |4 aut | |
| 700 | 1 | |a Yamagishi, Yuka |e verfasserin |4 aut | |
| 700 | 1 | |a Sakanashi, Daisuke |e verfasserin |4 aut | |
| 700 | 1 | |a Nakamura, Akiko |e verfasserin |4 aut | |
| 700 | 1 | |a Suematsu, Hiroyuki |e verfasserin |4 aut | |
| 700 | 1 | |a Ohnishi, Masafumi |e verfasserin |4 aut | |
| 700 | 1 | |a Mikamo, Hiroshige |e verfasserin |4 aut | |
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