Filamentous bacteriophages, natural nanoparticles, for viral vaccine strategies
Filamentous bacteriophages are natural nanoparticles formed by the self-assembly of structural proteins that have the capability of replication and infection. They are used as a highly efficient vaccine platform to enhance immunogenicity and effectively stimulate the innate and adaptive immune response. Compared with traditional vaccines, phage-based vaccines offer thermodynamic stability, biocompatibility, homogeneity, high carrying capacity, self-assembly, scalability, and low toxicity. This review summarizes recent research on phage-based vaccines in virus prevention. In addition, the expression systems of filamentous phage-based virus vaccines and their application principles are discussed. Moreover, the prospect of the prevention of emerging infectious diseases, such as coronavirus 2019 (COVID-19), is also discussed.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2022 |
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| Erschienen: |
2022 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:14 |
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| Enthalten in: |
Nanoscale - 14(2022), 16 vom: 21. Apr., Seite 5942-5959 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Wang, Yicun [VerfasserIn] |
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| Links: |
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| Anmerkungen: |
Date Completed 22.04.2022 Date Revised 22.04.2022 published: Electronic Citation Status MEDLINE |
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| doi: |
10.1039/d1nr08064d |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| 520 | |a Filamentous bacteriophages are natural nanoparticles formed by the self-assembly of structural proteins that have the capability of replication and infection. They are used as a highly efficient vaccine platform to enhance immunogenicity and effectively stimulate the innate and adaptive immune response. Compared with traditional vaccines, phage-based vaccines offer thermodynamic stability, biocompatibility, homogeneity, high carrying capacity, self-assembly, scalability, and low toxicity. This review summarizes recent research on phage-based vaccines in virus prevention. In addition, the expression systems of filamentous phage-based virus vaccines and their application principles are discussed. Moreover, the prospect of the prevention of emerging infectious diseases, such as coronavirus 2019 (COVID-19), is also discussed | ||
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| 700 | 1 | |a Cui, Ranji |e verfasserin |4 aut | |
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