Phylogeography and genomic epidemiology of SARS-CoV-2 in Italy and Europe with newly characterized Italian genomes between February-June 2020
© 2022. The Author(s)..
The aims of this study were to characterize new SARS-CoV-2 genomes sampled all over Italy and to reconstruct the origin and the evolutionary dynamics in Italy and Europe between February and June 2020. The cluster analysis showed only small clusters including < 80 Italian isolates, while most of the Italian strains were intermixed in the whole tree. Pure Italian clusters were observed mainly after the lockdown and distancing measures were adopted. Lineage B and B.1 spread between late January and early February 2020, from China to Veneto and Lombardy, respectively. Lineage B.1.1 (20B) most probably evolved within Italy and spread from central to south Italian regions, and to European countries. The lineage B.1.1.1 (20D) developed most probably in other European countries entering Italy only in the second half of March and remained localized in Piedmont until June 2020. In conclusion, within the limitations of phylogeographical reconstruction, the estimated ancestral scenario suggests an important role of China and Italy in the widespread diffusion of the D614G variant in Europe in the early phase of the pandemic and more dispersed exchanges involving several European countries from the second half of March 2020.
| Medienart: |
E-Artikel |
|---|
| Erscheinungsjahr: |
2022 |
|---|---|
| Erschienen: |
2022 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:12 |
|---|---|
| Enthalten in: |
Scientific reports - 12(2022), 1 vom: 06. Apr., Seite 5736 |
| Sprache: |
Englisch |
|---|
| Beteiligte Personen: |
Lai, Alessia [VerfasserIn] |
|---|
| Links: |
|---|
| Themen: |
|---|
| Anmerkungen: |
Date Completed 08.04.2022 Date Revised 19.05.2022 published: Electronic Citation Status MEDLINE |
|---|
| doi: |
10.1038/s41598-022-09738-0 |
|---|
| funding: |
|
|---|---|
| Förderinstitution / Projekttitel: |
|
| PPN (Katalog-ID): |
NLM339178272 |
|---|
| LEADER | 01000naa a22002652 4500 | ||
|---|---|---|---|
| 001 | NLM339178272 | ||
| 003 | DE-627 | ||
| 005 | 20231226204455.0 | ||
| 007 | cr uuu---uuuuu | ||
| 008 | 231226s2022 xx |||||o 00| ||eng c | ||
| 024 | 7 | |a 10.1038/s41598-022-09738-0 |2 doi | |
| 028 | 5 | 2 | |a pubmed24n1130.xml |
| 035 | |a (DE-627)NLM339178272 | ||
| 035 | |a (NLM)35388091 | ||
| 040 | |a DE-627 |b ger |c DE-627 |e rakwb | ||
| 041 | |a eng | ||
| 100 | 1 | |a Lai, Alessia |e verfasserin |4 aut | |
| 245 | 1 | 0 | |a Phylogeography and genomic epidemiology of SARS-CoV-2 in Italy and Europe with newly characterized Italian genomes between February-June 2020 |
| 264 | 1 | |c 2022 | |
| 336 | |a Text |b txt |2 rdacontent | ||
| 337 | |a ƒaComputermedien |b c |2 rdamedia | ||
| 338 | |a ƒa Online-Ressource |b cr |2 rdacarrier | ||
| 500 | |a Date Completed 08.04.2022 | ||
| 500 | |a Date Revised 19.05.2022 | ||
| 500 | |a published: Electronic | ||
| 500 | |a Citation Status MEDLINE | ||
| 520 | |a © 2022. The Author(s). | ||
| 520 | |a The aims of this study were to characterize new SARS-CoV-2 genomes sampled all over Italy and to reconstruct the origin and the evolutionary dynamics in Italy and Europe between February and June 2020. The cluster analysis showed only small clusters including < 80 Italian isolates, while most of the Italian strains were intermixed in the whole tree. Pure Italian clusters were observed mainly after the lockdown and distancing measures were adopted. Lineage B and B.1 spread between late January and early February 2020, from China to Veneto and Lombardy, respectively. Lineage B.1.1 (20B) most probably evolved within Italy and spread from central to south Italian regions, and to European countries. The lineage B.1.1.1 (20D) developed most probably in other European countries entering Italy only in the second half of March and remained localized in Piedmont until June 2020. In conclusion, within the limitations of phylogeographical reconstruction, the estimated ancestral scenario suggests an important role of China and Italy in the widespread diffusion of the D614G variant in Europe in the early phase of the pandemic and more dispersed exchanges involving several European countries from the second half of March 2020 | ||
| 650 | 4 | |a Journal Article | |
| 700 | 1 | |a Bergna, Annalisa |e verfasserin |4 aut | |
| 700 | 1 | |a Toppo, Stefano |e verfasserin |4 aut | |
| 700 | 1 | |a Morganti, Marina |e verfasserin |4 aut | |
| 700 | 1 | |a Menzo, Stefano |e verfasserin |4 aut | |
| 700 | 1 | |a Ghisetti, Valeria |e verfasserin |4 aut | |
| 700 | 1 | |a Bruzzone, Bianca |e verfasserin |4 aut | |
| 700 | 1 | |a Codeluppi, Mauro |e verfasserin |4 aut | |
| 700 | 1 | |a Fiore, Vito |e verfasserin |4 aut | |
| 700 | 1 | |a Rullo, Emmanuele Venanzi |e verfasserin |4 aut | |
| 700 | 1 | |a Antonelli, Guido |e verfasserin |4 aut | |
| 700 | 1 | |a Sarmati, Loredana |e verfasserin |4 aut | |
| 700 | 1 | |a Brindicci, Gaetano |e verfasserin |4 aut | |
| 700 | 1 | |a Callegaro, Annapaola |e verfasserin |4 aut | |
| 700 | 1 | |a Sagnelli, Caterina |e verfasserin |4 aut | |
| 700 | 1 | |a Francisci, Daniela |e verfasserin |4 aut | |
| 700 | 1 | |a Vicenti, Ilaria |e verfasserin |4 aut | |
| 700 | 1 | |a Miola, Arianna |e verfasserin |4 aut | |
| 700 | 1 | |a Tonon, Giovanni |e verfasserin |4 aut | |
| 700 | 1 | |a Cirillo, Daniela |e verfasserin |4 aut | |
| 700 | 1 | |a Menozzi, Ilaria |e verfasserin |4 aut | |
| 700 | 1 | |a Caucci, Sara |e verfasserin |4 aut | |
| 700 | 1 | |a Cerutti, Francesco |e verfasserin |4 aut | |
| 700 | 1 | |a Orsi, Andrea |e verfasserin |4 aut | |
| 700 | 1 | |a Schiavo, Roberta |e verfasserin |4 aut | |
| 700 | 1 | |a Babudieri, Sergio |e verfasserin |4 aut | |
| 700 | 1 | |a Nunnari, Giuseppe |e verfasserin |4 aut | |
| 700 | 1 | |a Mastroianni, Claudio M |e verfasserin |4 aut | |
| 700 | 1 | |a Andreoni, Massimo |e verfasserin |4 aut | |
| 700 | 1 | |a Monno, Laura |e verfasserin |4 aut | |
| 700 | 1 | |a Guarneri, Davide |e verfasserin |4 aut | |
| 700 | 1 | |a Coppola, Nicola |e verfasserin |4 aut | |
| 700 | 1 | |a Crisanti, Andrea |e verfasserin |4 aut | |
| 700 | 1 | |a Galli, Massimo |e verfasserin |4 aut | |
| 700 | 1 | |a Zehender, Gianguglielmo |e verfasserin |4 aut | |
| 700 | 0 | |a SCIRE-SARS-CoV-2 Italian Research Enterprise-Collaborative Group |e verfasserin |4 aut | |
| 700 | 1 | |a Balotta, Claudia |e investigator |4 oth | |
| 700 | 1 | |a Ventura, Carla Della |e investigator |4 oth | |
| 700 | 1 | |a Schiuma, Marco |e investigator |4 oth | |
| 700 | 1 | |a Lavezzo, Enrico |e investigator |4 oth | |
| 700 | 1 | |a Fontana, Paolo |e investigator |4 oth | |
| 700 | 1 | |a Bianco, Luca |e investigator |4 oth | |
| 700 | 1 | |a Bertolotti, Luigi |e investigator |4 oth | |
| 700 | 1 | |a Manuto, Laura |e investigator |4 oth | |
| 700 | 1 | |a Grazioli, Marco |e investigator |4 oth | |
| 700 | 1 | |a Bianca, Federico |e investigator |4 oth | |
| 700 | 1 | |a Del Vecchio, Claudia |e investigator |4 oth | |
| 700 | 1 | |a Franchin, Elisa |e investigator |4 oth | |
| 700 | 1 | |a Onelia, Francesco |e investigator |4 oth | |
| 700 | 1 | |a Spitaleri, Andrea |e investigator |4 oth | |
| 700 | 1 | |a Saluzzo, Francesca |e investigator |4 oth | |
| 700 | 1 | |a Lorenzin, Giovanni |e investigator |4 oth | |
| 700 | 1 | |a Pongolini, Stefano |e investigator |4 oth | |
| 700 | 1 | |a Scaltriti, Erika |e investigator |4 oth | |
| 700 | 1 | |a Soliani, Laura |e investigator |4 oth | |
| 700 | 1 | |a Bagnarelli, Patrizia |e investigator |4 oth | |
| 700 | 1 | |a Turchi, Chiara |e investigator |4 oth | |
| 700 | 1 | |a Onofri, Valerio |e investigator |4 oth | |
| 700 | 1 | |a Melchionda, Filomena |e investigator |4 oth | |
| 700 | 1 | |a Tagliabracci, Adriano |e investigator |4 oth | |
| 700 | 1 | |a Burdino, Elisa |e investigator |4 oth | |
| 700 | 1 | |a Milia, Maria Grazia |e investigator |4 oth | |
| 700 | 1 | |a Caligiuri, Patrizia |e investigator |4 oth | |
| 700 | 1 | |a De Pace, Vanessa |e investigator |4 oth | |
| 700 | 1 | |a Ricucci, Valentina |e investigator |4 oth | |
| 700 | 1 | |a Domnich, Alexander |e investigator |4 oth | |
| 700 | 1 | |a Boccotti, Simona |e investigator |4 oth | |
| 700 | 1 | |a Cristina, Leoni Maria |e investigator |4 oth | |
| 700 | 1 | |a Cascio, Giuliana Lo |e investigator |4 oth | |
| 700 | 1 | |a Rubino, Salvatore |e investigator |4 oth | |
| 700 | 1 | |a Lai, Vincenzo |e investigator |4 oth | |
| 700 | 1 | |a Rocca, Giulia |e investigator |4 oth | |
| 700 | 1 | |a Govoni, Rosalba |e investigator |4 oth | |
| 700 | 1 | |a Mancuso, Giuseppe |e investigator |4 oth | |
| 700 | 1 | |a Campagna, Roberta |e investigator |4 oth | |
| 700 | 1 | |a Mazzuti, Laura |e investigator |4 oth | |
| 700 | 1 | |a Oliveto, Giuseppe |e investigator |4 oth | |
| 700 | 1 | |a Turriziani, Ombretta |e investigator |4 oth | |
| 700 | 1 | |a Campogiani, Laura |e investigator |4 oth | |
| 700 | 1 | |a Compagno, Mirko |e investigator |4 oth | |
| 700 | 1 | |a Coppola, Luigi |e investigator |4 oth | |
| 700 | 1 | |a Crea, Angela Maria Antonia |e investigator |4 oth | |
| 700 | 1 | |a De Simone, Giuseppe |e investigator |4 oth | |
| 700 | 1 | |a Di Lorenzo, Andrea |e investigator |4 oth | |
| 700 | 1 | |a Ferrari, Ludovica |e investigator |4 oth | |
| 700 | 1 | |a Iannetta, Marco |e investigator |4 oth | |
| 700 | 1 | |a Malagnino, Vincenzo |e investigator |4 oth | |
| 700 | 1 | |a Mulas, Tiziana |e investigator |4 oth | |
| 700 | 1 | |a Rossi, Benedetta |e investigator |4 oth | |
| 700 | 1 | |a Spalliera, Ilaria |e investigator |4 oth | |
| 700 | 1 | |a Tedde, Simona |e investigator |4 oth | |
| 700 | 1 | |a Teti, Elisabetta |e investigator |4 oth | |
| 700 | 1 | |a Vitale, Pietro |e investigator |4 oth | |
| 700 | 1 | |a Zordan, Marta |e investigator |4 oth | |
| 700 | 1 | |a Milano, Eugenio |e investigator |4 oth | |
| 700 | 1 | |a Lagioia, Antonella |e investigator |4 oth | |
| 700 | 1 | |a Gallitelli, Rosa |e investigator |4 oth | |
| 700 | 1 | |a Starace, Mario |e investigator |4 oth | |
| 700 | 1 | |a Minichini, Carmine |e investigator |4 oth | |
| 700 | 1 | |a Di Fraia, Alessia |e investigator |4 oth | |
| 700 | 1 | |a Schioppa, Maddalena |e investigator |4 oth | |
| 700 | 1 | |a Greco, Rita |e investigator |4 oth | |
| 700 | 1 | |a Gidari, Anna |e investigator |4 oth | |
| 700 | 1 | |a Zazzi, Maurizio |e investigator |4 oth | |
| 700 | 1 | |a Dragoni, Filippo |e investigator |4 oth | |
| 700 | 1 | |a Puma, Laura Li |e investigator |4 oth | |
| 700 | 1 | |a Ronchiadin, Silvia |e investigator |4 oth | |
| 700 | 1 | |a Ruggerone, Luigi |e investigator |4 oth | |
| 700 | 1 | |a Russignaga, Dario |e investigator |4 oth | |
| 773 | 0 | 8 | |i Enthalten in |t Scientific reports |d 2011 |g 12(2022), 1 vom: 06. Apr., Seite 5736 |w (DE-627)NLM215703936 |x 2045-2322 |7 nnns |
| 773 | 1 | 8 | |g volume:12 |g year:2022 |g number:1 |g day:06 |g month:04 |g pages:5736 |
| 856 | 4 | 0 | |u http://dx.doi.org/10.1038/s41598-022-09738-0 |3 Volltext |
| 912 | |a GBV_USEFLAG_A | ||
| 912 | |a GBV_NLM | ||
| 951 | |a AR | ||
| 952 | |d 12 |j 2022 |e 1 |b 06 |c 04 |h 5736 | ||