The human vestibulo-ocular reflex and compensatory saccades in schwannoma patients before and after vestibular nerve section
Copyright © 2022. Published by Elsevier B.V..
OBJECTIVE: To examine the vestibulo-ocular reflex (VOR) and compensatory-saccades before and after complete unilateral vestibular deafferentation (UVD).
METHODS: Forty patients were studied before and after surgery for vestibular or facial schwannoma using the video head-impulse test (vHIT) and multivariable regression.
RESULTS: Prior to UVD (median(IQR), 14(58.4) days), the average VOR-gain towards the lesioned-ear was lower than in normal for all semicircular canals (lateral, anterior, posterior: 0.69, 0.72, 0.49). One-week after UVD (5(3.0) days) VOR gains were further reduced (0.22, 0.37, 0.27), however, within one-year after UVD (171(125.0) days) the lesioned-ear VOR gains had slightly increased (+0.08, +0.11, +0.03), maximally for the anterior-canal. After UVD, the VOR gain asymmetry (gain towards minus away from intact-ear) was lower for the intact posterior-canal plane (0.56, 0.56, 0.22). For the lesioned canals, the frequency and amplitude of the first compensatory-saccade increased from 61-93% and 1.9-3.6° pre-surgery, to 98-99% and to 3.1-5.9° one-week post-surgery and remained unchanged over one-year; second saccade frequency and amplitude decreased over the same timespan.
CONCLUSIONS: After UVD the high-acceleration VOR for the intact posterior-canal plane is more symmetrical than the other canals. First compensatory-saccades adapt within one week and subsequently change only marginally.
SIGNIFICANCE: Saccade compensation from surgical UVD is near complete by one-week.
| Errataetall: |
CommentIn: Clin Neurophysiol. 2022 Jun;138:189-190. - PMID 35339380 |
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| Medienart: |
E-Artikel |
| Erscheinungsjahr: |
2022 |
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| Erschienen: |
2022 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:138 |
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| Enthalten in: |
Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology - 138(2022) vom: 01. Juni, Seite 197-213 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Pogson, Jacob M [VerfasserIn] |
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| Links: |
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| Themen: |
Journal Article |
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| Anmerkungen: |
Date Completed 24.05.2022 Date Revised 23.06.2022 published: Print-Electronic figshare: 10.6084/m9.figshare.8868218 CommentIn: Clin Neurophysiol. 2022 Jun;138:189-190. - PMID 35339380 Citation Status MEDLINE |
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| doi: |
10.1016/j.clinph.2022.02.014 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM338999647 |
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| 100 | 1 | |a Pogson, Jacob M |e verfasserin |4 aut | |
| 245 | 1 | 4 | |a The human vestibulo-ocular reflex and compensatory saccades in schwannoma patients before and after vestibular nerve section |
| 264 | 1 | |c 2022 | |
| 336 | |a Text |b txt |2 rdacontent | ||
| 337 | |a ƒaComputermedien |b c |2 rdamedia | ||
| 338 | |a ƒa Online-Ressource |b cr |2 rdacarrier | ||
| 500 | |a Date Completed 24.05.2022 | ||
| 500 | |a Date Revised 23.06.2022 | ||
| 500 | |a published: Print-Electronic | ||
| 500 | |a figshare: 10.6084/m9.figshare.8868218 | ||
| 500 | |a CommentIn: Clin Neurophysiol. 2022 Jun;138:189-190. - PMID 35339380 | ||
| 500 | |a Citation Status MEDLINE | ||
| 520 | |a Copyright © 2022. Published by Elsevier B.V. | ||
| 520 | |a OBJECTIVE: To examine the vestibulo-ocular reflex (VOR) and compensatory-saccades before and after complete unilateral vestibular deafferentation (UVD) | ||
| 520 | |a METHODS: Forty patients were studied before and after surgery for vestibular or facial schwannoma using the video head-impulse test (vHIT) and multivariable regression | ||
| 520 | |a RESULTS: Prior to UVD (median(IQR), 14(58.4) days), the average VOR-gain towards the lesioned-ear was lower than in normal for all semicircular canals (lateral, anterior, posterior: 0.69, 0.72, 0.49). One-week after UVD (5(3.0) days) VOR gains were further reduced (0.22, 0.37, 0.27), however, within one-year after UVD (171(125.0) days) the lesioned-ear VOR gains had slightly increased (+0.08, +0.11, +0.03), maximally for the anterior-canal. After UVD, the VOR gain asymmetry (gain towards minus away from intact-ear) was lower for the intact posterior-canal plane (0.56, 0.56, 0.22). For the lesioned canals, the frequency and amplitude of the first compensatory-saccade increased from 61-93% and 1.9-3.6° pre-surgery, to 98-99% and to 3.1-5.9° one-week post-surgery and remained unchanged over one-year; second saccade frequency and amplitude decreased over the same timespan | ||
| 520 | |a CONCLUSIONS: After UVD the high-acceleration VOR for the intact posterior-canal plane is more symmetrical than the other canals. First compensatory-saccades adapt within one week and subsequently change only marginally | ||
| 520 | |a SIGNIFICANCE: Saccade compensation from surgical UVD is near complete by one-week | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a Research Support, Non-U.S. Gov't | |
| 650 | 4 | |a Saccades | |
| 650 | 4 | |a Schwannoma | |
| 650 | 4 | |a Vestibular system | |
| 650 | 4 | |a Vestibulo-ocular reflex | |
| 650 | 4 | |a Video head impulse test | |
| 700 | 1 | |a Taylor, Rachael L |e verfasserin |4 aut | |
| 700 | 1 | |a Bradshaw, Andrew P |e verfasserin |4 aut | |
| 700 | 1 | |a McGarvie, Leigh |e verfasserin |4 aut | |
| 700 | 1 | |a D'Souza, Mario |e verfasserin |4 aut | |
| 700 | 1 | |a Flanagan, Sean |e verfasserin |4 aut | |
| 700 | 1 | |a Kong, Jonathan |e verfasserin |4 aut | |
| 700 | 1 | |a Biggs, Nigel |e verfasserin |4 aut | |
| 700 | 1 | |a Shivalingam, Brindha |e verfasserin |4 aut | |
| 700 | 1 | |a Greenberg, Simon |e verfasserin |4 aut | |
| 700 | 1 | |a Croxson, Glen |e verfasserin |4 aut | |
| 700 | 1 | |a Halmagyi, G Michael |e verfasserin |4 aut | |
| 700 | 1 | |a Welgampola, Miriam S |e verfasserin |4 aut | |
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