Socioemotional deficit and HPA axis time response in high compulsive rats selected by schedule-induced polydipsia
Copyright © 2022 The Authors. Published by Elsevier Inc. All rights reserved..
Compulsivity is a failure to stop an ongoing behavior that has become inappropriate to the situation and is recognized as a transdiagnostic trait present in different neuropsychiatric disorders. The implication of motivation and emotion, as well as the stress response in compulsive population has not been fully understood. We assessed the motivation to reward and cues, the emotional response in different contexts and the hypothalamic-pituitary-adrenal (HPA) axis response in rats selected by a preclinical model of compulsive behavior. Firstly, high (HD) or low (LD) drinkers were selected according to their drinking behavior on schedule-induced polydipsia (SIP). Then, we assessed motivation by the propensity to attribute incentive salience to rewards on Pavlovian Conditioned Approach (PavCA) and motivation to gain reward on Progressive Ratio Schedule of Reinforcement (PRSR). Emotion was measured by Social Dominance on the Tube Test (SDTT) and emotional memory on Passive Avoidance (PA). Plasma corticosterone (CORT) levels in response to SIP were assessed. HD rats showed a socioemotional deficit by fewer victories on the SDTT, and an increased latency to enter the dark compartment on the PA. No differences were found between groups regarding to motivational assessment. Moreover, HD rats revealed a blunted time response in the increase of CORT levels at 45 min after SIP compared to LD rats. The findings show that the compulsive phenotype of HD rats exhibit less social dominance, more resistance to extinction and a differential CORT time response to SIP. These findings may contribute to highlight the relevance of assessing socioemotional behaviors and stress response for a better characterization of the vulnerability to compulsive spectrum disorders.
| Medienart: |
E-Artikel |
|---|
| Erscheinungsjahr: |
2022 |
|---|---|
| Erschienen: |
2022 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:142 |
|---|---|
| Enthalten in: |
Hormones and behavior - 142(2022) vom: 05. Juni, Seite 105170 |
| Sprache: |
Englisch |
|---|
| Beteiligte Personen: |
Martín-González, Elena [VerfasserIn] |
|---|
| Links: |
|---|
| Anmerkungen: |
Date Completed 08.06.2022 Date Revised 26.08.2022 published: Print-Electronic Citation Status MEDLINE |
|---|
| doi: |
10.1016/j.yhbeh.2022.105170 |
|---|
| funding: |
|
|---|---|
| Förderinstitution / Projekttitel: |
|
| PPN (Katalog-ID): |
NLM338976264 |
|---|
| LEADER | 01000naa a22002652 4500 | ||
|---|---|---|---|
| 001 | NLM338976264 | ||
| 003 | DE-627 | ||
| 005 | 20231226001858.0 | ||
| 007 | cr uuu---uuuuu | ||
| 008 | 231226s2022 xx |||||o 00| ||eng c | ||
| 024 | 7 | |a 10.1016/j.yhbeh.2022.105170 |2 doi | |
| 028 | 5 | 2 | |a pubmed24n1129.xml |
| 035 | |a (DE-627)NLM338976264 | ||
| 035 | |a (NLM)35367739 | ||
| 035 | |a (PII)S0018-506X(22)00064-2 | ||
| 040 | |a DE-627 |b ger |c DE-627 |e rakwb | ||
| 041 | |a eng | ||
| 100 | 1 | |a Martín-González, Elena |e verfasserin |4 aut | |
| 245 | 1 | 0 | |a Socioemotional deficit and HPA axis time response in high compulsive rats selected by schedule-induced polydipsia |
| 264 | 1 | |c 2022 | |
| 336 | |a Text |b txt |2 rdacontent | ||
| 337 | |a ƒaComputermedien |b c |2 rdamedia | ||
| 338 | |a ƒa Online-Ressource |b cr |2 rdacarrier | ||
| 500 | |a Date Completed 08.06.2022 | ||
| 500 | |a Date Revised 26.08.2022 | ||
| 500 | |a published: Print-Electronic | ||
| 500 | |a Citation Status MEDLINE | ||
| 520 | |a Copyright © 2022 The Authors. Published by Elsevier Inc. All rights reserved. | ||
| 520 | |a Compulsivity is a failure to stop an ongoing behavior that has become inappropriate to the situation and is recognized as a transdiagnostic trait present in different neuropsychiatric disorders. The implication of motivation and emotion, as well as the stress response in compulsive population has not been fully understood. We assessed the motivation to reward and cues, the emotional response in different contexts and the hypothalamic-pituitary-adrenal (HPA) axis response in rats selected by a preclinical model of compulsive behavior. Firstly, high (HD) or low (LD) drinkers were selected according to their drinking behavior on schedule-induced polydipsia (SIP). Then, we assessed motivation by the propensity to attribute incentive salience to rewards on Pavlovian Conditioned Approach (PavCA) and motivation to gain reward on Progressive Ratio Schedule of Reinforcement (PRSR). Emotion was measured by Social Dominance on the Tube Test (SDTT) and emotional memory on Passive Avoidance (PA). Plasma corticosterone (CORT) levels in response to SIP were assessed. HD rats showed a socioemotional deficit by fewer victories on the SDTT, and an increased latency to enter the dark compartment on the PA. No differences were found between groups regarding to motivational assessment. Moreover, HD rats revealed a blunted time response in the increase of CORT levels at 45 min after SIP compared to LD rats. The findings show that the compulsive phenotype of HD rats exhibit less social dominance, more resistance to extinction and a differential CORT time response to SIP. These findings may contribute to highlight the relevance of assessing socioemotional behaviors and stress response for a better characterization of the vulnerability to compulsive spectrum disorders | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a Research Support, Non-U.S. Gov't | |
| 650 | 4 | |a Compulsive behavior | |
| 650 | 4 | |a Corticosterone | |
| 650 | 4 | |a Emotion | |
| 650 | 4 | |a Extinction | |
| 650 | 4 | |a Hypothalamic-pituitary-adrenal axis | |
| 650 | 4 | |a Motivation | |
| 650 | 4 | |a Passive avoidance | |
| 650 | 4 | |a Schedule-induced polydipsia | |
| 650 | 4 | |a Social dominance | |
| 650 | 4 | |a Tube test | |
| 650 | 7 | |a Corticosterone |2 NLM | |
| 650 | 7 | |a W980KJ009P |2 NLM | |
| 700 | 1 | |a Olmedo-Córdoba, Manuela |e verfasserin |4 aut | |
| 700 | 1 | |a Prados-Pardo, Ángeles |e verfasserin |4 aut | |
| 700 | 1 | |a Cruz-Garzón, Daniel J |e verfasserin |4 aut | |
| 700 | 1 | |a Flores, Pilar |e verfasserin |4 aut | |
| 700 | 1 | |a Mora, Santiago |e verfasserin |4 aut | |
| 700 | 1 | |a Moreno, Margarita |e verfasserin |4 aut | |
| 773 | 0 | 8 | |i Enthalten in |t Hormones and behavior |d 1972 |g 142(2022) vom: 05. Juni, Seite 105170 |w (DE-627)NLM000202312 |x 1095-6867 |7 nnns |
| 773 | 1 | 8 | |g volume:142 |g year:2022 |g day:05 |g month:06 |g pages:105170 |
| 856 | 4 | 0 | |u http://dx.doi.org/10.1016/j.yhbeh.2022.105170 |3 Volltext |
| 912 | |a GBV_USEFLAG_A | ||
| 912 | |a GBV_NLM | ||
| 951 | |a AR | ||
| 952 | |d 142 |j 2022 |b 05 |c 06 |h 105170 | ||