Methods for induction and assessment of intestinal permeability in rodent models of radiation injury
Copyright © 2022 Elsevier Inc. All rights reserved..
Ionizing radiation (IR) is a significant contributor to the contemporary market of energy production and an important diagnostic and treatment modality. Besides having numerous useful applications, it is also a ubiquitous environmental stressor and a potent genotoxic and epigenotoxic agent, capable of causing substantial damage to organs and tissues of living organisms. The gastrointestinal (GI) tract is highly sensitive to IR. This problem is further compounded by the fact that there is no FDA-approved medication to mitigate acute radiation-induced GI syndrome. Therefore, establishing the animal model for studying IR-induced GI-injury is crucially important to understand the harmful consequences of intestinal radiation damage. Here, we discuss two different animal models of IR-induced acute gastrointestinal syndrome and two separate methods for measuring the magnitude of intestinal radiation damage.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2022 |
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| Erschienen: |
2022 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:168 |
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| Enthalten in: |
Methods in cell biology - 168(2022) vom: 02., Seite 235-247 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Ewing, Laura E [VerfasserIn] |
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| Links: |
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| Themen: |
Abdominal irradiation |
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| Anmerkungen: |
Date Completed 05.04.2022 Date Revised 14.02.2024 published: Print-Electronic Citation Status MEDLINE |
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| doi: |
10.1016/bs.mcb.2021.12.017 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| 520 | |a Copyright © 2022 Elsevier Inc. All rights reserved. | ||
| 520 | |a Ionizing radiation (IR) is a significant contributor to the contemporary market of energy production and an important diagnostic and treatment modality. Besides having numerous useful applications, it is also a ubiquitous environmental stressor and a potent genotoxic and epigenotoxic agent, capable of causing substantial damage to organs and tissues of living organisms. The gastrointestinal (GI) tract is highly sensitive to IR. This problem is further compounded by the fact that there is no FDA-approved medication to mitigate acute radiation-induced GI syndrome. Therefore, establishing the animal model for studying IR-induced GI-injury is crucially important to understand the harmful consequences of intestinal radiation damage. Here, we discuss two different animal models of IR-induced acute gastrointestinal syndrome and two separate methods for measuring the magnitude of intestinal radiation damage | ||
| 650 | 4 | |a Journal Article | |
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| 650 | 4 | |a Abdominal irradiation | |
| 650 | 4 | |a Intestinal permeability | |
| 650 | 4 | |a Leaky gut | |
| 650 | 4 | |a Radiation injury | |
| 650 | 4 | |a Rodent model | |
| 700 | 1 | |a Biju, Prabath G |e verfasserin |4 aut | |
| 700 | 1 | |a Pathak, Rupak |e verfasserin |4 aut | |
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| 700 | 1 | |a Hauer-Jensen, Martin |e verfasserin |4 aut | |
| 700 | 1 | |a Koturbash, Igor |e verfasserin |4 aut | |
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