Promyelocytic leukemia protein is a restriction factor for Junín virus independently of Z matrix protein
Copyright © 2022 Elsevier Inc. All rights reserved..
The New World (NW) mammarenavirus Junín (JUNV) is the etiological agent of Argentine hemorrhagic fever, a human endemic disease of Argentina. Promyelocytic leukemia protein (PML) has been reported as a restriction factor for several viruses although the mechanism/s behind PML-mediated antiviral effect may be diverse and are a matter of debate. Previous studies have reported a nuclear to cytoplasm translocation of PML during the murine Old World mammarenavirus lymphocytic choriomeningitis virus (LCMV) infection. This translocation was found to be mediated by the viral Z protein. Here, we show that PML restricts JUNV infection in human A549 cells. However, in contrast to LCVM, JUNV infection enhances PML expression and PML is not translocated to the cytoplasm neither it colocalizes with JUNV Z protein. Our study demonstrates that a NW mammarenavirus as JUNV interacts differently with the antiviral protein PML than LCMV.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2022 |
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| Erschienen: |
2022 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:606 |
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| Enthalten in: |
Biochemical and biophysical research communications - 606(2022) vom: 28. Mai, Seite 168-173 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Giovannoni, Federico [VerfasserIn] |
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| Links: |
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| Themen: |
Journal Article |
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| Anmerkungen: |
Date Completed 26.04.2022 Date Revised 31.05.2022 published: Print-Electronic Citation Status MEDLINE |
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| doi: |
10.1016/j.bbrc.2022.03.074 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM338942327 |
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| 245 | 1 | 0 | |a Promyelocytic leukemia protein is a restriction factor for Junín virus independently of Z matrix protein |
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| 520 | |a Copyright © 2022 Elsevier Inc. All rights reserved. | ||
| 520 | |a The New World (NW) mammarenavirus Junín (JUNV) is the etiological agent of Argentine hemorrhagic fever, a human endemic disease of Argentina. Promyelocytic leukemia protein (PML) has been reported as a restriction factor for several viruses although the mechanism/s behind PML-mediated antiviral effect may be diverse and are a matter of debate. Previous studies have reported a nuclear to cytoplasm translocation of PML during the murine Old World mammarenavirus lymphocytic choriomeningitis virus (LCMV) infection. This translocation was found to be mediated by the viral Z protein. Here, we show that PML restricts JUNV infection in human A549 cells. However, in contrast to LCVM, JUNV infection enhances PML expression and PML is not translocated to the cytoplasm neither it colocalizes with JUNV Z protein. Our study demonstrates that a NW mammarenavirus as JUNV interacts differently with the antiviral protein PML than LCMV | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a Junín virus | |
| 650 | 4 | |a Mammarenavirus | |
| 650 | 4 | |a Promyelocytic leukemia protein | |
| 650 | 4 | |a Restriction factor | |
| 650 | 7 | |a Promyelocytic Leukemia Protein |2 NLM | |
| 650 | 7 | |a Viral Proteins |2 NLM | |
| 700 | 1 | |a Vazquez, Cecilia A |e verfasserin |4 aut | |
| 700 | 1 | |a Thomas, Pablo |e verfasserin |4 aut | |
| 700 | 1 | |a Gómez, Ricardo M |e verfasserin |4 aut | |
| 700 | 1 | |a García, Cybele C |e verfasserin |4 aut | |
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