Rational construction of a triphenylphosphine-modified tetra-nuclear Cu(I) coordinated cluster for enhanced chemodynamic therapy
A triphenylphosphine-modified tetra-nuclear Cu(I) coordinated cluster was constructed for enhanced chemodynamic therapy (CDT) by increasing the number of metal centers. Once inside human bladder cancer (T24) cells, a larger amount of copper accumulated compared with the mono-nuclear Cu(I) complex; the additional copper could generate more •OH and then induce more obvious apoptosis via a Fenton-like reaction, thus further increasing the tumor inhibition effect and ultimately improving the CDT efficiency.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2022 |
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| Erschienen: |
2022 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:51 |
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| Enthalten in: |
Dalton transactions (Cambridge, England : 2003) - 51(2022), 15 vom: 12. Apr., Seite 5782-5787 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
You, Xin [VerfasserIn] |
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| Links: |
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| Themen: |
26D26OA393 |
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| Anmerkungen: |
Date Completed 13.04.2022 Date Revised 13.04.2022 published: Electronic Citation Status MEDLINE |
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| doi: |
10.1039/d2dt00063f |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM338839267 |
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| 520 | |a A triphenylphosphine-modified tetra-nuclear Cu(I) coordinated cluster was constructed for enhanced chemodynamic therapy (CDT) by increasing the number of metal centers. Once inside human bladder cancer (T24) cells, a larger amount of copper accumulated compared with the mono-nuclear Cu(I) complex; the additional copper could generate more •OH and then induce more obvious apoptosis via a Fenton-like reaction, thus further increasing the tumor inhibition effect and ultimately improving the CDT efficiency | ||
| 650 | 4 | |a Journal Article | |
| 650 | 7 | |a Organophosphorus Compounds |2 NLM | |
| 650 | 7 | |a triphenylphosphine |2 NLM | |
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| 700 | 1 | |a Shi, Sheng-Mei |e verfasserin |4 aut | |
| 700 | 1 | |a Bian, He-Dong |e verfasserin |4 aut | |
| 700 | 1 | |a Zhang, Yun-Liang |e verfasserin |4 aut | |
| 700 | 1 | |a Zhang, Liang-Liang |e verfasserin |4 aut | |
| 700 | 1 | |a Huang, Fu-Ping |e verfasserin |4 aut | |
| 700 | 1 | |a Zhao, Shu-Lin |e verfasserin |4 aut | |
| 700 | 1 | |a Liang, Hong |e verfasserin |4 aut | |
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