Sleeve gastrectomy in patients with severe obesity and baseline chronic kidney disease improves kidney function independently of weight loss : a propensity score matched analysis
Copyright © 2022 American Society for Bariatric Surgery. Published by Elsevier Inc. All rights reserved..
BACKGROUND: In the last 10 years, severe obesity and the associated metabolic syndrome have reached pandemic proportions and consequently have significantly increased the prevalence of related co-morbidities such as chronic kidney disease (CKD). One in 7 people in the United States have CKD, and 90% of those are not aware of it.
OBJECTIVES: Following sleeve gastrectomy (SG) in patients with severe obesity and baseline CKD stage ≥2, to determine improvement of glomerular function and analyze the relationship between kidney function and weight loss.
SETTING: US Hospital, Academic Institution.
METHODS: We retrospectively reviewed the charts of all patients who underwent SG at our institution from 2010 to 2019. Kidney function assessment using the Chronic Kidney Disease Epidemiology Collaboration Study (CKD-EPI) equation and classification was carried out preoperatively and postoperatively at 12-months follow-up. Propensity score matching (1:1 ratio) was used to balance the distribution of covariates between patients with a baseline estimated glomerular filtration rate (eGFR) <90 mL/min/1.73 m2 and patients with normal kidney function.
RESULTS: We calculated the eGFR of 1330 bariatric patients who underwent SG. Of these patients, 18.79% (n = 250) met the criteria for CKD-EPI eGFR calculation preoperatively and at 12-months follow-up after SG. From the 250 patients included in the analysis, 42% (n = 105) were classified as CKD stage ≥2. When comparing the baseline preoperative eGFR at 12-months follow-up after SG, we observed an improvement of 8.26 ± 11.89 mL/min/1.73 m2 in CKD stage ≥2 (eGFR <90 mL/min/1.73 m2) as compared with 1.98 ± 10.25 mL/min/1.73 m2 in patients with eGFR >90 mL/min/1.73 m2 (P < .001).
CONCLUSION: There is short-term improvement of the eGFR in patients with severe obesity following SG. This improvement is significant in CKD stages ≥2 and seems unrelated to weight loss.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2022 |
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| Erschienen: |
2022 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:18 |
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| Enthalten in: |
Surgery for obesity and related diseases : official journal of the American Society for Bariatric Surgery - 18(2022), 6 vom: 15. Juni, Seite 772-778 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Funes, David Romero [VerfasserIn] |
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| Links: |
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| Themen: |
Bariatric surgery |
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| Anmerkungen: |
Date Completed 08.06.2022 Date Revised 14.07.2022 published: Print-Electronic Citation Status MEDLINE |
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| doi: |
10.1016/j.soard.2022.02.006 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM338619283 |
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| 100 | 1 | |a Funes, David Romero |e verfasserin |4 aut | |
| 245 | 1 | 0 | |a Sleeve gastrectomy in patients with severe obesity and baseline chronic kidney disease improves kidney function independently of weight loss |b a propensity score matched analysis |
| 264 | 1 | |c 2022 | |
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| 500 | |a Date Completed 08.06.2022 | ||
| 500 | |a Date Revised 14.07.2022 | ||
| 500 | |a published: Print-Electronic | ||
| 500 | |a Citation Status MEDLINE | ||
| 520 | |a Copyright © 2022 American Society for Bariatric Surgery. Published by Elsevier Inc. All rights reserved. | ||
| 520 | |a BACKGROUND: In the last 10 years, severe obesity and the associated metabolic syndrome have reached pandemic proportions and consequently have significantly increased the prevalence of related co-morbidities such as chronic kidney disease (CKD). One in 7 people in the United States have CKD, and 90% of those are not aware of it | ||
| 520 | |a OBJECTIVES: Following sleeve gastrectomy (SG) in patients with severe obesity and baseline CKD stage ≥2, to determine improvement of glomerular function and analyze the relationship between kidney function and weight loss | ||
| 520 | |a SETTING: US Hospital, Academic Institution | ||
| 520 | |a METHODS: We retrospectively reviewed the charts of all patients who underwent SG at our institution from 2010 to 2019. Kidney function assessment using the Chronic Kidney Disease Epidemiology Collaboration Study (CKD-EPI) equation and classification was carried out preoperatively and postoperatively at 12-months follow-up. Propensity score matching (1:1 ratio) was used to balance the distribution of covariates between patients with a baseline estimated glomerular filtration rate (eGFR) <90 mL/min/1.73 m2 and patients with normal kidney function | ||
| 520 | |a RESULTS: We calculated the eGFR of 1330 bariatric patients who underwent SG. Of these patients, 18.79% (n = 250) met the criteria for CKD-EPI eGFR calculation preoperatively and at 12-months follow-up after SG. From the 250 patients included in the analysis, 42% (n = 105) were classified as CKD stage ≥2. When comparing the baseline preoperative eGFR at 12-months follow-up after SG, we observed an improvement of 8.26 ± 11.89 mL/min/1.73 m2 in CKD stage ≥2 (eGFR <90 mL/min/1.73 m2) as compared with 1.98 ± 10.25 mL/min/1.73 m2 in patients with eGFR >90 mL/min/1.73 m2 (P < .001) | ||
| 520 | |a CONCLUSION: There is short-term improvement of the eGFR in patients with severe obesity following SG. This improvement is significant in CKD stages ≥2 and seems unrelated to weight loss | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a Bariatric surgery | |
| 650 | 4 | |a Chronic kidney disease | |
| 650 | 4 | |a Kidney function | |
| 650 | 4 | |a Obesity | |
| 650 | 4 | |a Sleeve gastrectomy | |
| 700 | 1 | |a Montorfano, Lisandro |e verfasserin |4 aut | |
| 700 | 1 | |a Blanco, David Gutierrez |e verfasserin |4 aut | |
| 700 | 1 | |a Cobos, Mauricio Sarmiento |e verfasserin |4 aut | |
| 700 | 1 | |a Lo Menzo, Emanuele |e verfasserin |4 aut | |
| 700 | 1 | |a Szomstein, Samuel |e verfasserin |4 aut | |
| 700 | 1 | |a Agrawal, Neerja |e verfasserin |4 aut | |
| 700 | 1 | |a Rosenthal, Raul J |e verfasserin |4 aut | |
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