Antipsychotic Polypharmacy-Related Cardiovascular Morbidity and Mortality : A Comprehensive Review
Schizophrenia is a psychotic disorder that exists at the more extreme end of a spectrum of diseases, and significantly affects daily functioning. Cardiovascular adverse effects of antipsychotic medications are well known, and include changes in blood pressure and arrhythmias. Sudden cardiac death is the leading cause of death worldwide, and antipsychotic medications are associated with numerous cardiac side effects. A possible link exists between antipsychotic medications and sudden cardiac death. Common prescribing patterns that may influence cardiovascular events include the use of multiple antipsychotics and/or additional drugs commonly prescribed to patients on antipsychotics. The results of this review reflect an association between antipsychotic drugs and increased risk of ventricular arrhythmias and sudden cardiac death by iatrogenic prolongation of the QTc interval. QTc prolongation and sudden cardiac death exist in patients taking antipsychotic monotherapy. The risk increases for the concomitant use of specific drugs that prolong the QTc interval, such as opioids, antibiotics, and illicit drugs. However, evidence suggests that QTc intervals may not adequately predict sudden cardiac death. In considering the findings of this narrative review, we conclude that it is unclear whether there is a precise association between antipsychotic polypharmacy and sudden cardiac death with QTc interval changes. The present narrative review warrants further research on this important potential association.
Medienart: |
E-Artikel |
---|
Erscheinungsjahr: |
2022 |
---|---|
Erschienen: |
2022 |
Enthalten in: |
Zur Gesamtaufnahme - volume:14 |
---|---|
Enthalten in: |
Neurology international - 14(2022), 1 vom: 17. März, Seite 294-309 |
Sprache: |
Englisch |
---|
Beteiligte Personen: |
Edinoff, Amber N [VerfasserIn] |
---|
Links: |
---|
Themen: |
Antipsychotics |
---|
Anmerkungen: |
Date Revised 29.03.2022 published: Electronic Citation Status PubMed-not-MEDLINE |
---|
doi: |
10.3390/neurolint14010024 |
---|
funding: |
|
---|---|
Förderinstitution / Projekttitel: |
|
PPN (Katalog-ID): |
NLM33854884X |
---|
LEADER | 01000naa a22002652 4500 | ||
---|---|---|---|
001 | NLM33854884X | ||
003 | DE-627 | ||
005 | 20231226000923.0 | ||
007 | cr uuu---uuuuu | ||
008 | 231226s2022 xx |||||o 00| ||eng c | ||
024 | 7 | |a 10.3390/neurolint14010024 |2 doi | |
028 | 5 | 2 | |a pubmed24n1128.xml |
035 | |a (DE-627)NLM33854884X | ||
035 | |a (NLM)35324580 | ||
040 | |a DE-627 |b ger |c DE-627 |e rakwb | ||
041 | |a eng | ||
100 | 1 | |a Edinoff, Amber N |e verfasserin |4 aut | |
245 | 1 | 0 | |a Antipsychotic Polypharmacy-Related Cardiovascular Morbidity and Mortality |b A Comprehensive Review |
264 | 1 | |c 2022 | |
336 | |a Text |b txt |2 rdacontent | ||
337 | |a ƒaComputermedien |b c |2 rdamedia | ||
338 | |a ƒa Online-Ressource |b cr |2 rdacarrier | ||
500 | |a Date Revised 29.03.2022 | ||
500 | |a published: Electronic | ||
500 | |a Citation Status PubMed-not-MEDLINE | ||
520 | |a Schizophrenia is a psychotic disorder that exists at the more extreme end of a spectrum of diseases, and significantly affects daily functioning. Cardiovascular adverse effects of antipsychotic medications are well known, and include changes in blood pressure and arrhythmias. Sudden cardiac death is the leading cause of death worldwide, and antipsychotic medications are associated with numerous cardiac side effects. A possible link exists between antipsychotic medications and sudden cardiac death. Common prescribing patterns that may influence cardiovascular events include the use of multiple antipsychotics and/or additional drugs commonly prescribed to patients on antipsychotics. The results of this review reflect an association between antipsychotic drugs and increased risk of ventricular arrhythmias and sudden cardiac death by iatrogenic prolongation of the QTc interval. QTc prolongation and sudden cardiac death exist in patients taking antipsychotic monotherapy. The risk increases for the concomitant use of specific drugs that prolong the QTc interval, such as opioids, antibiotics, and illicit drugs. However, evidence suggests that QTc intervals may not adequately predict sudden cardiac death. In considering the findings of this narrative review, we conclude that it is unclear whether there is a precise association between antipsychotic polypharmacy and sudden cardiac death with QTc interval changes. The present narrative review warrants further research on this important potential association | ||
650 | 4 | |a Journal Article | |
650 | 4 | |a Review | |
650 | 4 | |a QTc prolongation | |
650 | 4 | |a antipsychotics | |
650 | 4 | |a cardiac events | |
650 | 4 | |a polypharmacy | |
650 | 4 | |a schizophrenia | |
700 | 1 | |a Ellis, Emily D |e verfasserin |4 aut | |
700 | 1 | |a Nussdorf, Laura M |e verfasserin |4 aut | |
700 | 1 | |a Hill, Taylor W |e verfasserin |4 aut | |
700 | 1 | |a Cornett, Elyse M |e verfasserin |4 aut | |
700 | 1 | |a Kaye, Adam M |e verfasserin |4 aut | |
700 | 1 | |a Kaye, Alan D |e verfasserin |4 aut | |
773 | 0 | 8 | |i Enthalten in |t Neurology international |d 2009 |g 14(2022), 1 vom: 17. März, Seite 294-309 |w (DE-627)NLM208279466 |x 2035-8385 |7 nnns |
773 | 1 | 8 | |g volume:14 |g year:2022 |g number:1 |g day:17 |g month:03 |g pages:294-309 |
856 | 4 | 0 | |u http://dx.doi.org/10.3390/neurolint14010024 |3 Volltext |
912 | |a GBV_USEFLAG_A | ||
912 | |a GBV_NLM | ||
951 | |a AR | ||
952 | |d 14 |j 2022 |e 1 |b 17 |c 03 |h 294-309 |