Clinical Feasibility of Structural and Functional MRI in Free-Breathing Neonates and Infants
© 2022 International Society for Magnetic Resonance in Medicine..
BACKGROUND: Evaluation of structural lung abnormalities with magnetic resonance imaging (MRI) has previously been shown to be predictive of clinical neonatal outcomes in preterm birth. MRI during free-breathing with phase-resolved functional lung (PREFUL) may allow for complimentary functional information without exogenous contrast.
PURPOSE: To investigate the feasibility of structural and functional pulmonary MRI in a cohort of neonates and infants with no cardiorespiratory disease. Macrovascular pulmonary blood flows were also evaluated.
STUDY TYPE: Prospective.
POPULATION: Ten term infants with no clinically defined cardiorespiratory disease were imaged. Infants recruited from the general population and neonatal intensive care unit (NICU) were studied.
FIELD STRENGTH/SEQUENCE: T1 -weighted VIBE, T2 -weighted BLADE uncorrected for motion. Ultrashort echo time (UTE) and 3D-flow data were acquired during free-breathing with self-navigation and retrospective reconstruction. Single slice 2D-gradient echo (GRE) images were acquired during free-breathing for PREFUL analysis. Imaging was performed at 3 T.
ASSESSMENT: T1 , T2 , and UTE images were scored according to the modified Ochiai scheme by three pediatric body radiologists. Ventilation/perfusion-weighted maps were extracted from free-breathing GRE images using PREFUL analysis. Ventilation and perfusion defect percent (VDP, QDP) were calculated from the segmented ventilation and perfusion-weighted maps. Time-averaged cardiac blood velocities from three-dimensional-flow were evaluated in major pulmonary arteries and veins.
STATISTICAL TEST: Intraclass correlation coefficient (ICC).
RESULTS: The ICC of replicate structural scores was 0.81 (95% CI: 0.45-0.95) across three observers. Elevated Ochiai scores, VDP, and QDP were observed in two NICU participants. Excluding these participants, mean ± standard deviation structural scores were 1.2 ± 0.8, while VDP and QDP were 1.0% ± 1.1% and 0.4% ± 0.5%, respectively. Main pulmonary arterial blood flows normalized to body surface area were 3.15 ± 0.78 L/min/m2.
DATA CONCLUSION: Structural and functional pulmonary imaging is feasible using standard clinical MRI hardware (commercial whole-body 3 T scanner, table spine array, and flexible thoracic array) in free-breathing infants.
EVIDENCE LEVEL: 2 TECHNICAL EFFICACY: Stage 1.
| Errataetall: |
CommentIn: J Magn Reson Imaging. 2022 Jun;55(6):1708-1709. - PMID 35312209 |
|---|---|
| Medienart: |
E-Artikel |
| Erscheinungsjahr: |
2022 |
|---|---|
| Erschienen: |
2022 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:55 |
|---|---|
| Enthalten in: |
Journal of magnetic resonance imaging : JMRI - 55(2022), 6 vom: 01. Juni, Seite 1696-1707 |
| Sprache: |
Englisch |
|---|
| Beteiligte Personen: |
Zanette, Brandon [VerfasserIn] |
|---|
| Links: |
|---|
| Themen: |
Blood flow |
|---|
| Anmerkungen: |
Date Completed 17.05.2022 Date Revised 21.05.2022 published: Print-Electronic CommentIn: J Magn Reson Imaging. 2022 Jun;55(6):1708-1709. - PMID 35312209 Citation Status MEDLINE |
|---|
| doi: |
10.1002/jmri.28165 |
|---|
| funding: |
|
|---|---|
| Förderinstitution / Projekttitel: |
|
| PPN (Katalog-ID): |
NLM338426949 |
|---|
| LEADER | 01000naa a22002652 4500 | ||
|---|---|---|---|
| 001 | NLM338426949 | ||
| 003 | DE-627 | ||
| 005 | 20231226000642.0 | ||
| 007 | cr uuu---uuuuu | ||
| 008 | 231226s2022 xx |||||o 00| ||eng c | ||
| 024 | 7 | |a 10.1002/jmri.28165 |2 doi | |
| 028 | 5 | 2 | |a pubmed24n1128.xml |
| 035 | |a (DE-627)NLM338426949 | ||
| 035 | |a (NLM)35312203 | ||
| 040 | |a DE-627 |b ger |c DE-627 |e rakwb | ||
| 041 | |a eng | ||
| 100 | 1 | |a Zanette, Brandon |e verfasserin |4 aut | |
| 245 | 1 | 0 | |a Clinical Feasibility of Structural and Functional MRI in Free-Breathing Neonates and Infants |
| 264 | 1 | |c 2022 | |
| 336 | |a Text |b txt |2 rdacontent | ||
| 337 | |a ƒaComputermedien |b c |2 rdamedia | ||
| 338 | |a ƒa Online-Ressource |b cr |2 rdacarrier | ||
| 500 | |a Date Completed 17.05.2022 | ||
| 500 | |a Date Revised 21.05.2022 | ||
| 500 | |a published: Print-Electronic | ||
| 500 | |a CommentIn: J Magn Reson Imaging. 2022 Jun;55(6):1708-1709. - PMID 35312209 | ||
| 500 | |a Citation Status MEDLINE | ||
| 520 | |a © 2022 International Society for Magnetic Resonance in Medicine. | ||
| 520 | |a BACKGROUND: Evaluation of structural lung abnormalities with magnetic resonance imaging (MRI) has previously been shown to be predictive of clinical neonatal outcomes in preterm birth. MRI during free-breathing with phase-resolved functional lung (PREFUL) may allow for complimentary functional information without exogenous contrast | ||
| 520 | |a PURPOSE: To investigate the feasibility of structural and functional pulmonary MRI in a cohort of neonates and infants with no cardiorespiratory disease. Macrovascular pulmonary blood flows were also evaluated | ||
| 520 | |a STUDY TYPE: Prospective | ||
| 520 | |a POPULATION: Ten term infants with no clinically defined cardiorespiratory disease were imaged. Infants recruited from the general population and neonatal intensive care unit (NICU) were studied | ||
| 520 | |a FIELD STRENGTH/SEQUENCE: T1 -weighted VIBE, T2 -weighted BLADE uncorrected for motion. Ultrashort echo time (UTE) and 3D-flow data were acquired during free-breathing with self-navigation and retrospective reconstruction. Single slice 2D-gradient echo (GRE) images were acquired during free-breathing for PREFUL analysis. Imaging was performed at 3 T | ||
| 520 | |a ASSESSMENT: T1 , T2 , and UTE images were scored according to the modified Ochiai scheme by three pediatric body radiologists. Ventilation/perfusion-weighted maps were extracted from free-breathing GRE images using PREFUL analysis. Ventilation and perfusion defect percent (VDP, QDP) were calculated from the segmented ventilation and perfusion-weighted maps. Time-averaged cardiac blood velocities from three-dimensional-flow were evaluated in major pulmonary arteries and veins | ||
| 520 | |a STATISTICAL TEST: Intraclass correlation coefficient (ICC) | ||
| 520 | |a RESULTS: The ICC of replicate structural scores was 0.81 (95% CI: 0.45-0.95) across three observers. Elevated Ochiai scores, VDP, and QDP were observed in two NICU participants. Excluding these participants, mean ± standard deviation structural scores were 1.2 ± 0.8, while VDP and QDP were 1.0% ± 1.1% and 0.4% ± 0.5%, respectively. Main pulmonary arterial blood flows normalized to body surface area were 3.15 ± 0.78 L/min/m2 | ||
| 520 | |a DATA CONCLUSION: Structural and functional pulmonary imaging is feasible using standard clinical MRI hardware (commercial whole-body 3 T scanner, table spine array, and flexible thoracic array) in free-breathing infants | ||
| 520 | |a EVIDENCE LEVEL: 2 TECHNICAL EFFICACY: Stage 1 | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a Research Support, Non-U.S. Gov't | |
| 650 | 4 | |a blood flow | |
| 650 | 4 | |a free-breathing | |
| 650 | 4 | |a function | |
| 650 | 4 | |a infants | |
| 650 | 4 | |a lung | |
| 650 | 4 | |a structure | |
| 700 | 1 | |a Schrauben, Eric M |e verfasserin |4 aut | |
| 700 | 1 | |a Munidasa, Samal |e verfasserin |4 aut | |
| 700 | 1 | |a Goolaub, Datta S |e verfasserin |4 aut | |
| 700 | 1 | |a Singh, Anuradha |e verfasserin |4 aut | |
| 700 | 1 | |a Coblentz, Ailish |e verfasserin |4 aut | |
| 700 | 1 | |a Stirrat, Elaine |e verfasserin |4 aut | |
| 700 | 1 | |a Couch, Marcus J |e verfasserin |4 aut | |
| 700 | 1 | |a Grimm, Robert |e verfasserin |4 aut | |
| 700 | 1 | |a Voskrebenzev, Andreas |e verfasserin |4 aut | |
| 700 | 1 | |a Vogel-Claussen, Jens |e verfasserin |4 aut | |
| 700 | 1 | |a Seethamraju, Ravi T |e verfasserin |4 aut | |
| 700 | 1 | |a Macgowan, Christopher K |e verfasserin |4 aut | |
| 700 | 1 | |a Greer, Mary-Louise C |e verfasserin |4 aut | |
| 700 | 1 | |a Tam, Emily W Y |e verfasserin |4 aut | |
| 700 | 1 | |a Santyr, Giles |e verfasserin |4 aut | |
| 773 | 0 | 8 | |i Enthalten in |t Journal of magnetic resonance imaging : JMRI |d 1996 |g 55(2022), 6 vom: 01. Juni, Seite 1696-1707 |w (DE-627)NLM013085476 |x 1522-2586 |7 nnns |
| 773 | 1 | 8 | |g volume:55 |g year:2022 |g number:6 |g day:01 |g month:06 |g pages:1696-1707 |
| 856 | 4 | 0 | |u http://dx.doi.org/10.1002/jmri.28165 |3 Volltext |
| 912 | |a GBV_USEFLAG_A | ||
| 912 | |a GBV_NLM | ||
| 951 | |a AR | ||
| 952 | |d 55 |j 2022 |e 6 |b 01 |c 06 |h 1696-1707 | ||