Effects of Stable Vagus Nerve Stimulation Efficacy on Autistic Behaviors in Ten Pediatric Patients With Drug Resistant Epilepsy : An Observational Study
Copyright © 2022 Wang, Yuan, Zhang, Wen, Cheng, Qin, Ji, Shu, Jiang, Liao, Hao, Li and Wu..
Vagus nerve stimulation (VNS) is a safe and effective therapy for pediatric patients with drug-resistant epilepsy (DRE). However, in children with DRE, the effects of VNS on autistic behaviors remain controversial. We retrospectively collected data from 10 children with DRE who underwent VNS implantation and regular parameter regulation in three pediatric epilepsy centers, and completed the behavioral assessments, including the autistic behavior checklist and the child behavior checklist, at follow-ups 1 (mean 2.16 years) and 2 (mean 2.98 years). The 10 children maintained stable seizure control between the two follow-ups. Their autistic behaviors, especially in language, social and self-help, were reduced at follow-up 2 compared to follow-up 1 (p = 0.01, p = 0.01, respectively). Moreover, these improvements were not associated with their seizure control, whether it was positive or negative. These results suggested that the VNS had a positive effect on autistic behaviors, which provided a preliminary clinical basis that VNS may benefit to younger children with DRE comorbidity autism spectrum disorder (ASD).
| Medienart: |
E-Artikel |
|---|
| Erscheinungsjahr: |
2022 |
|---|---|
| Erschienen: |
2022 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:10 |
|---|---|
| Enthalten in: |
Frontiers in pediatrics - 10(2022) vom: 11., Seite 846301 |
| Sprache: |
Englisch |
|---|
| Beteiligte Personen: |
Wang, Zhiyan [VerfasserIn] |
|---|
| Links: |
|---|
| Themen: |
Autistic behavior |
|---|
| Anmerkungen: |
Date Revised 07.01.2023 published: Electronic-eCollection Citation Status PubMed-not-MEDLINE |
|---|
| doi: |
10.3389/fped.2022.846301 |
|---|
| funding: |
|
|---|---|
| Förderinstitution / Projekttitel: |
|
| PPN (Katalog-ID): |
NLM338415483 |
|---|
| LEADER | 01000naa a22002652 4500 | ||
|---|---|---|---|
| 001 | NLM338415483 | ||
| 003 | DE-627 | ||
| 005 | 20231226000626.0 | ||
| 007 | cr uuu---uuuuu | ||
| 008 | 231226s2022 xx |||||o 00| ||eng c | ||
| 024 | 7 | |a 10.3389/fped.2022.846301 |2 doi | |
| 028 | 5 | 2 | |a pubmed24n1128.xml |
| 035 | |a (DE-627)NLM338415483 | ||
| 035 | |a (NLM)35311037 | ||
| 040 | |a DE-627 |b ger |c DE-627 |e rakwb | ||
| 041 | |a eng | ||
| 100 | 1 | |a Wang, Zhiyan |e verfasserin |4 aut | |
| 245 | 1 | 0 | |a Effects of Stable Vagus Nerve Stimulation Efficacy on Autistic Behaviors in Ten Pediatric Patients With Drug Resistant Epilepsy |b An Observational Study |
| 264 | 1 | |c 2022 | |
| 336 | |a Text |b txt |2 rdacontent | ||
| 337 | |a ƒaComputermedien |b c |2 rdamedia | ||
| 338 | |a ƒa Online-Ressource |b cr |2 rdacarrier | ||
| 500 | |a Date Revised 07.01.2023 | ||
| 500 | |a published: Electronic-eCollection | ||
| 500 | |a Citation Status PubMed-not-MEDLINE | ||
| 520 | |a Copyright © 2022 Wang, Yuan, Zhang, Wen, Cheng, Qin, Ji, Shu, Jiang, Liao, Hao, Li and Wu. | ||
| 520 | |a Vagus nerve stimulation (VNS) is a safe and effective therapy for pediatric patients with drug-resistant epilepsy (DRE). However, in children with DRE, the effects of VNS on autistic behaviors remain controversial. We retrospectively collected data from 10 children with DRE who underwent VNS implantation and regular parameter regulation in three pediatric epilepsy centers, and completed the behavioral assessments, including the autistic behavior checklist and the child behavior checklist, at follow-ups 1 (mean 2.16 years) and 2 (mean 2.98 years). The 10 children maintained stable seizure control between the two follow-ups. Their autistic behaviors, especially in language, social and self-help, were reduced at follow-up 2 compared to follow-up 1 (p = 0.01, p = 0.01, respectively). Moreover, these improvements were not associated with their seizure control, whether it was positive or negative. These results suggested that the VNS had a positive effect on autistic behaviors, which provided a preliminary clinical basis that VNS may benefit to younger children with DRE comorbidity autism spectrum disorder (ASD) | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a autistic behavior | |
| 650 | 4 | |a comorbidity | |
| 650 | 4 | |a drug resistant epilepsy | |
| 650 | 4 | |a pediatric patients | |
| 650 | 4 | |a vagus nerve stimulation | |
| 700 | 1 | |a Yuan, Xing |e verfasserin |4 aut | |
| 700 | 1 | |a Zhang, Qian |e verfasserin |4 aut | |
| 700 | 1 | |a Wen, Jialun |e verfasserin |4 aut | |
| 700 | 1 | |a Cheng, Tungyang |e verfasserin |4 aut | |
| 700 | 1 | |a Qin, Xiaoya |e verfasserin |4 aut | |
| 700 | 1 | |a Ji, Taoyun |e verfasserin |4 aut | |
| 700 | 1 | |a Shu, Xiaomei |e verfasserin |4 aut | |
| 700 | 1 | |a Jiang, Yuwu |e verfasserin |4 aut | |
| 700 | 1 | |a Liao, Jianxiang |e verfasserin |4 aut | |
| 700 | 1 | |a Hao, Hongwei |e verfasserin |4 aut | |
| 700 | 1 | |a Li, Luming |e verfasserin |4 aut | |
| 700 | 1 | |a Wu, Ye |e verfasserin |4 aut | |
| 773 | 0 | 8 | |i Enthalten in |t Frontiers in pediatrics |d 2013 |g 10(2022) vom: 11., Seite 846301 |w (DE-627)NLM234254327 |x 2296-2360 |7 nnns |
| 773 | 1 | 8 | |g volume:10 |g year:2022 |g day:11 |g pages:846301 |
| 856 | 4 | 0 | |u http://dx.doi.org/10.3389/fped.2022.846301 |3 Volltext |
| 912 | |a GBV_USEFLAG_A | ||
| 912 | |a GBV_NLM | ||
| 951 | |a AR | ||
| 952 | |d 10 |j 2022 |b 11 |h 846301 | ||