A case of successive development of possible acute necrotizing encephalopathy after COVID-19 pneumonia
© The Author(s) 2022..
COVID-19 infection often results in an excessive inflammatory response with a spectrum of neurological manifestations. Here, we describe an 81-year-old female with severe COVID-19 pneumonia and subsequent alteration of consciousness after high-dose intravenous dexamethasone and remdesivir. A non-contrast head computed tomography (CT) demonstrated bilateral hypodensities involving bilateral cerebellar hemispheres, thalami, cerebral peduncles and medial parieto-occipital areas. There was no improvement and repeat CT showed progression with findings suggestive of acute necrotizing encephalopathy. Interleukin-6 levels were initially normal; however, subsequent levels were found to be markedly elevated. Acute necrotizing encephalopathy associated with COVID-19 may occur in the setting of severe pneumonia and may represent an immune-mediated process involving inflammatory cytokines such as interleukin-6.
| Medienart: |
E-Artikel |
|---|
| Erscheinungsjahr: |
2022 |
|---|---|
| Erschienen: |
2022 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:10 |
|---|---|
| Enthalten in: |
SAGE open medical case reports - 10(2022) vom: 23., Seite 2050313X221083653 |
| Sprache: |
Englisch |
|---|
| Beteiligte Personen: |
Hemachudha, Pasin [VerfasserIn] |
|---|
| Links: |
|---|
| Themen: |
Acute necrotizing encephalopathy |
|---|
| Anmerkungen: |
Date Revised 22.03.2022 published: Electronic-eCollection Citation Status PubMed-not-MEDLINE |
|---|
| doi: |
10.1177/2050313X221083653 |
|---|
| funding: |
|
|---|---|
| Förderinstitution / Projekttitel: |
|
| PPN (Katalog-ID): |
NLM338385606 |
|---|
| LEADER | 01000naa a22002652 4500 | ||
|---|---|---|---|
| 001 | NLM338385606 | ||
| 003 | DE-627 | ||
| 005 | 20231226000542.0 | ||
| 007 | cr uuu---uuuuu | ||
| 008 | 231226s2022 xx |||||o 00| ||eng c | ||
| 024 | 7 | |a 10.1177/2050313X221083653 |2 doi | |
| 028 | 5 | 2 | |a pubmed24n1127.xml |
| 035 | |a (DE-627)NLM338385606 | ||
| 035 | |a (NLM)35308052 | ||
| 040 | |a DE-627 |b ger |c DE-627 |e rakwb | ||
| 041 | |a eng | ||
| 100 | 1 | |a Hemachudha, Pasin |e verfasserin |4 aut | |
| 245 | 1 | 2 | |a A case of successive development of possible acute necrotizing encephalopathy after COVID-19 pneumonia |
| 264 | 1 | |c 2022 | |
| 336 | |a Text |b txt |2 rdacontent | ||
| 337 | |a ƒaComputermedien |b c |2 rdamedia | ||
| 338 | |a ƒa Online-Ressource |b cr |2 rdacarrier | ||
| 500 | |a Date Revised 22.03.2022 | ||
| 500 | |a published: Electronic-eCollection | ||
| 500 | |a Citation Status PubMed-not-MEDLINE | ||
| 520 | |a © The Author(s) 2022. | ||
| 520 | |a COVID-19 infection often results in an excessive inflammatory response with a spectrum of neurological manifestations. Here, we describe an 81-year-old female with severe COVID-19 pneumonia and subsequent alteration of consciousness after high-dose intravenous dexamethasone and remdesivir. A non-contrast head computed tomography (CT) demonstrated bilateral hypodensities involving bilateral cerebellar hemispheres, thalami, cerebral peduncles and medial parieto-occipital areas. There was no improvement and repeat CT showed progression with findings suggestive of acute necrotizing encephalopathy. Interleukin-6 levels were initially normal; however, subsequent levels were found to be markedly elevated. Acute necrotizing encephalopathy associated with COVID-19 may occur in the setting of severe pneumonia and may represent an immune-mediated process involving inflammatory cytokines such as interleukin-6 | ||
| 650 | 4 | |a Case Reports | |
| 650 | 4 | |a COVID-19 | |
| 650 | 4 | |a acute necrotizing encephalopathy | |
| 650 | 4 | |a interleukin-6 | |
| 700 | 1 | |a Pongpitakmetha, Thanakit |e verfasserin |4 aut | |
| 700 | 1 | |a Rattanawong, Wanakorn |e verfasserin |4 aut | |
| 700 | 1 | |a Thanapornsungsuth, Poosanu |e verfasserin |4 aut | |
| 700 | 1 | |a Joyjinda, Yutthana |e verfasserin |4 aut | |
| 700 | 1 | |a Bunprakob, Saowalak |e verfasserin |4 aut | |
| 700 | 1 | |a Ruchisrisarod, Chanida |e verfasserin |4 aut | |
| 700 | 1 | |a Hemachudha, Thiravat |e verfasserin |4 aut | |
| 773 | 0 | 8 | |i Enthalten in |t SAGE open medical case reports |d 2013 |g 10(2022) vom: 23., Seite 2050313X221083653 |w (DE-627)NLM263108392 |x 2050-313X |7 nnns |
| 773 | 1 | 8 | |g volume:10 |g year:2022 |g day:23 |g pages:2050313X221083653 |
| 856 | 4 | 0 | |u http://dx.doi.org/10.1177/2050313X221083653 |3 Volltext |
| 912 | |a GBV_USEFLAG_A | ||
| 912 | |a GBV_NLM | ||
| 951 | |a AR | ||
| 952 | |d 10 |j 2022 |b 23 |h 2050313X221083653 | ||