CORRELATION OF CARDIAC BIOMARKERS WITH THE LEVELS OF SELENIUM AND ANTIOXIDANT ENZYMES IN PATIENTS WITH ACUTE MYOCARDIAL INFARCTION AND A HISTORY OF HYPERTENSION
OBJECTIVE: The aim: To determine the interrelations between the levels of antioxidant enzymes, selenium and the markers of myocardial injury in patients with non-ST segment elevation myocardial infarction and a history of antecedent arterial hypertension.
PATIENTS AND METHODS: Materials and methods: A total of 72 patients with non-ST segment elevation myocardial infarctionwere examined (42 with antecedent hypertension - group 1; 30-without hypertension - group2).
RESULTS: Results: Patients of group 1 were characterized by significantly higher troponin I levels (p = 0.006), creatine kinase MB levels (p=0.008) and lower levels of superoxide dismutase (p=0.005), catalase (p=0.003) and selenium (p=0.008) as compared with group 2. In both groups, the activity of superoxide dismutase had an inverse correlation with troponin I: (r = -0.46, p = 0.005) and (r = -0.38, p = 0.004), respectively. A significant inverse relationships were found between selenium levels and both markers of myocardial injury in group 1 (p≤0.009), whereas in group 2 a weak correlation was found between the levels of selenium and troponin I only (p=0.006).
CONCLUSION: Conclusions: The obtained data suggest that the levels of selenium and antioxidant enzymes in blood of all patients with non-ST elevation myocardial infarction inversely correlate with cardiac biomarkers. Patients with non-ST elevation myocardial infarction and a history of hypertension have significantly lower levels of antioxidant agents, higher levels of markers of myocardial injury, and stronger connections between them, indicating the development of more significant myocardial injury.
| Medienart: |
Artikel |
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| Erscheinungsjahr: |
2022 |
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| Erschienen: |
2022 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:75 |
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| Enthalten in: |
Wiadomosci lekarskie (Warsaw, Poland : 1960) - 75(2022), 2 vom: 20., Seite 362-365 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Filonenko, Maryna [VerfasserIn] |
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| Themen: |
Antioxidant enzymes |
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| Anmerkungen: |
Date Completed 22.03.2022 Date Revised 22.03.2022 published: Print Citation Status MEDLINE |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM338381740 |
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| 245 | 1 | 0 | |a CORRELATION OF CARDIAC BIOMARKERS WITH THE LEVELS OF SELENIUM AND ANTIOXIDANT ENZYMES IN PATIENTS WITH ACUTE MYOCARDIAL INFARCTION AND A HISTORY OF HYPERTENSION |
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| 500 | |a Date Completed 22.03.2022 | ||
| 500 | |a Date Revised 22.03.2022 | ||
| 500 | |a published: Print | ||
| 500 | |a Citation Status MEDLINE | ||
| 520 | |a OBJECTIVE: The aim: To determine the interrelations between the levels of antioxidant enzymes, selenium and the markers of myocardial injury in patients with non-ST segment elevation myocardial infarction and a history of antecedent arterial hypertension | ||
| 520 | |a PATIENTS AND METHODS: Materials and methods: A total of 72 patients with non-ST segment elevation myocardial infarctionwere examined (42 with antecedent hypertension - group 1; 30-without hypertension - group2) | ||
| 520 | |a RESULTS: Results: Patients of group 1 were characterized by significantly higher troponin I levels (p = 0.006), creatine kinase MB levels (p=0.008) and lower levels of superoxide dismutase (p=0.005), catalase (p=0.003) and selenium (p=0.008) as compared with group 2. In both groups, the activity of superoxide dismutase had an inverse correlation with troponin I: (r = -0.46, p = 0.005) and (r = -0.38, p = 0.004), respectively. A significant inverse relationships were found between selenium levels and both markers of myocardial injury in group 1 (p≤0.009), whereas in group 2 a weak correlation was found between the levels of selenium and troponin I only (p=0.006) | ||
| 520 | |a CONCLUSION: Conclusions: The obtained data suggest that the levels of selenium and antioxidant enzymes in blood of all patients with non-ST elevation myocardial infarction inversely correlate with cardiac biomarkers. Patients with non-ST elevation myocardial infarction and a history of hypertension have significantly lower levels of antioxidant agents, higher levels of markers of myocardial injury, and stronger connections between them, indicating the development of more significant myocardial injury | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a antioxidant enzymes | |
| 650 | 4 | |a cardiac biomarkers | |
| 650 | 4 | |a hypertension | |
| 650 | 4 | |a myocardial infarction | |
| 650 | 4 | |a selenium | |
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| 650 | 7 | |a Biomarkers |2 NLM | |
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| 700 | 1 | |a Sokolnikova, Nelya |e verfasserin |4 aut | |
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