Recent applications of vinyl sulfone motif in drug design and discovery
Copyright © 2022 Elsevier Masson SAS. All rights reserved..
Vinyl sulfone with electrophilic character is not only a versatile building block for various organic transformations but also is a key structural unit in a large number of biologically active molecules. In the recent decades vinyl sulfone has attracted much attention due to its potential as a privileged structural motif in medicinal chemistry for the drug discovery and development. It can be found in the chemical structure of many leads and drug candidates such as Rigosertib, Recilisib, K11777, WRR-483 and BAY 11-7085. The vinyl sulfone motif has been especially used in the design of chemotherapeutics and neuroprotective as well as radioprotective agents. In this review, we have described design, chemical structures, biological properties and related mechanism of actions, and structure activity relationship (SAR) study of vinyl sulfone-based compounds.
| Medienart: |
E-Artikel |
|---|
| Erscheinungsjahr: |
2022 |
|---|---|
| Erschienen: |
2022 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:234 |
|---|---|
| Enthalten in: |
European journal of medicinal chemistry - 234(2022) vom: 15. Apr., Seite 114255 |
| Sprache: |
Englisch |
|---|
| Beteiligte Personen: |
Ahmadi, Reza [VerfasserIn] |
|---|
| Links: |
|---|
| Themen: |
α,β-unsaturated sulfones |
|---|
| Anmerkungen: |
Date Completed 12.04.2022 Date Revised 12.04.2022 published: Print-Electronic Citation Status MEDLINE |
|---|
| doi: |
10.1016/j.ejmech.2022.114255 |
|---|
| funding: |
|
|---|---|
| Förderinstitution / Projekttitel: |
|
| PPN (Katalog-ID): |
NLM338359931 |
|---|
| LEADER | 01000naa a22002652 4500 | ||
|---|---|---|---|
| 001 | NLM338359931 | ||
| 003 | DE-627 | ||
| 005 | 20231226000508.0 | ||
| 007 | cr uuu---uuuuu | ||
| 008 | 231226s2022 xx |||||o 00| ||eng c | ||
| 024 | 7 | |a 10.1016/j.ejmech.2022.114255 |2 doi | |
| 028 | 5 | 2 | |a pubmed24n1127.xml |
| 035 | |a (DE-627)NLM338359931 | ||
| 035 | |a (NLM)35305462 | ||
| 035 | |a (PII)S0223-5234(22)00157-X | ||
| 040 | |a DE-627 |b ger |c DE-627 |e rakwb | ||
| 041 | |a eng | ||
| 100 | 1 | |a Ahmadi, Reza |e verfasserin |4 aut | |
| 245 | 1 | 0 | |a Recent applications of vinyl sulfone motif in drug design and discovery |
| 264 | 1 | |c 2022 | |
| 336 | |a Text |b txt |2 rdacontent | ||
| 337 | |a ƒaComputermedien |b c |2 rdamedia | ||
| 338 | |a ƒa Online-Ressource |b cr |2 rdacarrier | ||
| 500 | |a Date Completed 12.04.2022 | ||
| 500 | |a Date Revised 12.04.2022 | ||
| 500 | |a published: Print-Electronic | ||
| 500 | |a Citation Status MEDLINE | ||
| 520 | |a Copyright © 2022 Elsevier Masson SAS. All rights reserved. | ||
| 520 | |a Vinyl sulfone with electrophilic character is not only a versatile building block for various organic transformations but also is a key structural unit in a large number of biologically active molecules. In the recent decades vinyl sulfone has attracted much attention due to its potential as a privileged structural motif in medicinal chemistry for the drug discovery and development. It can be found in the chemical structure of many leads and drug candidates such as Rigosertib, Recilisib, K11777, WRR-483 and BAY 11-7085. The vinyl sulfone motif has been especially used in the design of chemotherapeutics and neuroprotective as well as radioprotective agents. In this review, we have described design, chemical structures, biological properties and related mechanism of actions, and structure activity relationship (SAR) study of vinyl sulfone-based compounds | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a Review | |
| 650 | 4 | |a Bioactive compounds | |
| 650 | 4 | |a Drug design | |
| 650 | 4 | |a Lead generation | |
| 650 | 4 | |a α,β-unsaturated sulfones | |
| 650 | 7 | |a Sulfones |2 NLM | |
| 650 | 7 | |a Vinyl Compounds |2 NLM | |
| 650 | 7 | |a divinyl sulfone |2 NLM | |
| 650 | 7 | |a 5PFN71LP8M |2 NLM | |
| 700 | 1 | |a Emami, Saeed |e verfasserin |4 aut | |
| 773 | 0 | 8 | |i Enthalten in |t European journal of medicinal chemistry |d 1994 |g 234(2022) vom: 15. Apr., Seite 114255 |w (DE-627)NLM106608835 |x 1768-3254 |7 nnns |
| 773 | 1 | 8 | |g volume:234 |g year:2022 |g day:15 |g month:04 |g pages:114255 |
| 856 | 4 | 0 | |u http://dx.doi.org/10.1016/j.ejmech.2022.114255 |3 Volltext |
| 912 | |a GBV_USEFLAG_A | ||
| 912 | |a GBV_NLM | ||
| 951 | |a AR | ||
| 952 | |d 234 |j 2022 |b 15 |c 04 |h 114255 | ||