First-in-human study of blood amyloid β removal from early Alzheimer's disease patients with normal kidney function
© 2022 International Society for Apheresis and Japanese Society for Apheresis..
INTRODUCTION: Amyloid β (Aβ) is a brain protein that causes Alzheimer's disease (AD). This study aimed to verify whether hemadsorption using a hexadecyl-alkylated cellulose bead (HexDC) column removes blood Aβ and brain Aβ accumulation in mild cognitive impairment/mild AD cases with normal kidney function.
METHODS: Two patients with positive Aβ on brain imaging underwent HexDC hemadsorption weekly for 6 months.
RESULTS: The Aβ removal efficiency of HexDC was 87-99%. Aβ1-40 /Aβ1-42 influx into the blood in one session was 596/56 and 489/48 ng for Case A and Case B, respectively. Although brain Aβ accumulation did not clearly change after 6 months of hemadsorption, cognitive functions measured by the two tests were maintained or slightly improved.
CONCLUSION: Blood Aβ removal was performed in two early AD patients with normal kidney function without adverse events, and it slightly improved or maintained cognitive function.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2022 |
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| Erschienen: |
2022 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:26 |
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| Enthalten in: |
Therapeutic apheresis and dialysis : official peer-reviewed journal of the International Society for Apheresis, the Japanese Society for Apheresis, the Japanese Society for Dialysis Therapy - 26(2022), 3 vom: 20. Juni, Seite 529-536 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Hasegawa, Midori [VerfasserIn] |
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| Links: |
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| Themen: |
Aβ |
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| Anmerkungen: |
Date Completed 02.05.2022 Date Revised 02.05.2022 published: Print-Electronic Citation Status MEDLINE |
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| doi: |
10.1111/1744-9987.13827 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM33825451X |
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| 500 | |a published: Print-Electronic | ||
| 500 | |a Citation Status MEDLINE | ||
| 520 | |a © 2022 International Society for Apheresis and Japanese Society for Apheresis. | ||
| 520 | |a INTRODUCTION: Amyloid β (Aβ) is a brain protein that causes Alzheimer's disease (AD). This study aimed to verify whether hemadsorption using a hexadecyl-alkylated cellulose bead (HexDC) column removes blood Aβ and brain Aβ accumulation in mild cognitive impairment/mild AD cases with normal kidney function | ||
| 520 | |a METHODS: Two patients with positive Aβ on brain imaging underwent HexDC hemadsorption weekly for 6 months | ||
| 520 | |a RESULTS: The Aβ removal efficiency of HexDC was 87-99%. Aβ1-40 /Aβ1-42 influx into the blood in one session was 596/56 and 489/48 ng for Case A and Case B, respectively. Although brain Aβ accumulation did not clearly change after 6 months of hemadsorption, cognitive functions measured by the two tests were maintained or slightly improved | ||
| 520 | |a CONCLUSION: Blood Aβ removal was performed in two early AD patients with normal kidney function without adverse events, and it slightly improved or maintained cognitive function | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a Alzheimer's disease | |
| 650 | 4 | |a Aβ | |
| 650 | 4 | |a amyloid β | |
| 650 | 4 | |a hemadsorption | |
| 650 | 4 | |a hexadecyl-alkylated cellulose beads column | |
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| 700 | 1 | |a Kitaguchi, Nobuya |e verfasserin |4 aut | |
| 700 | 1 | |a Takechi, Hajime |e verfasserin |4 aut | |
| 700 | 1 | |a Kawaguchi, Kazunori |e verfasserin |4 aut | |
| 700 | 1 | |a Ito, Kengo |e verfasserin |4 aut | |
| 700 | 1 | |a Kato, Takashi |e verfasserin |4 aut | |
| 700 | 1 | |a Kato, Masao |e verfasserin |4 aut | |
| 700 | 1 | |a Nii, Norio |e verfasserin |4 aut | |
| 700 | 1 | |a Yamada, Sachie |e verfasserin |4 aut | |
| 700 | 1 | |a Ohashi, Atsushi |e verfasserin |4 aut | |
| 700 | 1 | |a Koide, Shigehisa |e verfasserin |4 aut | |
| 700 | 1 | |a Hayashi, Hiroki |e verfasserin |4 aut | |
| 700 | 1 | |a Takahashi, Kazuo |e verfasserin |4 aut | |
| 700 | 1 | |a Inaguma, Daijo |e verfasserin |4 aut | |
| 700 | 1 | |a Yuzawa, Yukio |e verfasserin |4 aut | |
| 700 | 1 | |a Tsuboi, Naotake |e verfasserin |4 aut | |
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