Promising Effects of Naringenin and Melatonin against Hepatic Encephalopathy Impairments Induced by Bile Duct Ligation in Male Rats
Copyright© Bentham Science Publishers; For any queries, please email at epubbenthamscience.net..
BACKGROUND: Bile duct ligation (BDL) is used for evaluating the protective effects of different agents with anti-inflammatory and antioxidant properties against the liver and brain damages. Naringenin (N) and melatonin (M) are used as protectants in various models of diseases.
AIMS: In the current research, the combinational effects of these well-known anti-inflammatory and antioxidants agents were investigated against cerebral injuries induced by BDL in male rats.
METHODS: The animals were distributed into the following groups: Sham, BDL + Vehicle and BDL+ N + M. Neuronal damages were evaluated using biochemical, motor behavioral tasks and morphological assessments.
RESULTS: Based on the data, BDL resulted in decreasing locomotor activity, which was reversed by N and M. Morphological study confirmed that BDL led to neurodegeneration in the cortex of the rats, and the N and M treatment preserved cortical neurons. In addition, immunohistochemical (IHC) study of the rat cortex showed that BDL resulted in increasing the activated astrocytes, and the N and M treatment reduced the number of activated cells.
CONCLUSION: These results obviously depicted combinational therapy with N and M to exert positive effects in the BDL rats, probably due to their synergistic anti-inflammatory and antioxidant activities.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2022 |
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| Erschienen: |
2022 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:22 |
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| Enthalten in: |
Central nervous system agents in medicinal chemistry - 22(2022), 1 vom: 15., Seite 31-38 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Raviz, Elahe Karami [VerfasserIn] |
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| Links: |
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| Themen: |
Anti-inflammatory |
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| Anmerkungen: |
Date Completed 29.07.2022 Date Revised 29.07.2022 published: Print Citation Status MEDLINE |
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| doi: |
10.2174/1871524922666220314123052 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM338199713 |
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| 245 | 1 | 0 | |a Promising Effects of Naringenin and Melatonin against Hepatic Encephalopathy Impairments Induced by Bile Duct Ligation in Male Rats |
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| 500 | |a Date Revised 29.07.2022 | ||
| 500 | |a published: Print | ||
| 500 | |a Citation Status MEDLINE | ||
| 520 | |a Copyright© Bentham Science Publishers; For any queries, please email at epubbenthamscience.net. | ||
| 520 | |a BACKGROUND: Bile duct ligation (BDL) is used for evaluating the protective effects of different agents with anti-inflammatory and antioxidant properties against the liver and brain damages. Naringenin (N) and melatonin (M) are used as protectants in various models of diseases | ||
| 520 | |a AIMS: In the current research, the combinational effects of these well-known anti-inflammatory and antioxidants agents were investigated against cerebral injuries induced by BDL in male rats | ||
| 520 | |a METHODS: The animals were distributed into the following groups: Sham, BDL + Vehicle and BDL+ N + M. Neuronal damages were evaluated using biochemical, motor behavioral tasks and morphological assessments | ||
| 520 | |a RESULTS: Based on the data, BDL resulted in decreasing locomotor activity, which was reversed by N and M. Morphological study confirmed that BDL led to neurodegeneration in the cortex of the rats, and the N and M treatment preserved cortical neurons. In addition, immunohistochemical (IHC) study of the rat cortex showed that BDL resulted in increasing the activated astrocytes, and the N and M treatment reduced the number of activated cells | ||
| 520 | |a CONCLUSION: These results obviously depicted combinational therapy with N and M to exert positive effects in the BDL rats, probably due to their synergistic anti-inflammatory and antioxidant activities | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a Bile duct ligation | |
| 650 | 4 | |a anti-inflammatory | |
| 650 | 4 | |a anti-oxidant | |
| 650 | 4 | |a melatonin | |
| 650 | 4 | |a naringenin | |
| 650 | 4 | |a open field | |
| 650 | 4 | |a rat | |
| 650 | 7 | |a Antioxidants |2 NLM | |
| 650 | 7 | |a Flavanones |2 NLM | |
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| 650 | 7 | |a JL5DK93RCL |2 NLM | |
| 700 | 1 | |a Noormand, Fatemeh |e verfasserin |4 aut | |
| 700 | 1 | |a Kermani, Ali Sharifzadeh |e verfasserin |4 aut | |
| 700 | 1 | |a Galedari, Ali |e verfasserin |4 aut | |
| 700 | 1 | |a Esmaeilpour, Khadijeh |e verfasserin |4 aut | |
| 700 | 1 | |a Maneshian, Marzieh |e verfasserin |4 aut | |
| 700 | 1 | |a Kalantaripour, Taj Pari |e verfasserin |4 aut | |
| 700 | 1 | |a Dabiri, Shahriar |e verfasserin |4 aut | |
| 700 | 1 | |a Asadi-Shekaari, Majid |e verfasserin |4 aut | |
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