Mortality risk factors in patients with SARS-CoV-2 infection and atrial fibrillation : Data from the SEMI-COVID-19 registry
Copyright © 2022 Elsevier España, S.L.U. All rights reserved..
INTRODUCTION: Atrial fibrillation and associated comorbidities pose a risk factor for mortality, morbidity and development of complications in patients admitted for COVID-19.
OBJECTIVES: To describe the clinical, epidemiological, radiological and analytical characteristics of patients with atrial fibrillation admitted for COVID-19 in Spain. Secondarily, we aim to identify those variables associated with mortality and poor prognosis of COVID-19 in patients with atrial fibrillation.
METHODS: Retrospective, observational, multicenter, nationwide, retrospective study of patients hospitalized for COVID-19 from March 1 to October 1, 2020. Data were obtained from the SEMI-COVID-19 Registry of the Spanish Society of Internal Medicine (SEMI) in which 150 Spanish hospitals participate.
RESULTS: Between March 1 and October 1, 2020, data from a total of 16,461 patients were entered into the SEMI-COVID-19 registry. 1816 (11%) had a history of atrial fibrillation and the number of deaths among AF patients amounted to 738 (41%). Regarding clinical characteristics, deceased patients were admitted with a higher heart rate (88.38 vs. 84.95; P>0.01), with a higher percentage of respiratory failure (67.2 vs. 20.1%; P<0.01) and high tachypnea (58 vs. 30%; P<0.01). The comorbidities that presented statistically significant differences in the deceased group were: age, hypertension and diabetes with target organ involvement. There was also a higher prevalence of a history of cardiovascular disease in the deceased. On multivariate analysis, DOACs treatment had a protective role for mortality (OR: 0.597; CI: 0.402-0.888; P=0.011).
CONCLUSIONS: Previous treatment with DOACs and DOACs treatment during admission seem to have a protective role in patients with atrial fibrillation, although this fact should be verified in prospective studies.
| Errataetall: |
CommentIn: Med Clin (Barc). 2022 Nov 11;159(9):e61. - PMID 35933189 |
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| Medienart: |
E-Artikel |
| Erscheinungsjahr: |
2022 |
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| Erschienen: |
2022 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:159 |
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| Enthalten in: |
Medicina clinica - 159(2022), 10 vom: 25. Nov., Seite 457-464 |
| Sprache: |
Englisch |
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| Weiterer Titel: |
Factores de riesgo de mortalidad en pacientes con infección por SARS-CoV-2 y fibrilación auricular: datos del registro SEMI-COVID-19 |
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| Beteiligte Personen: |
Azaña Gómez, Javier [VerfasserIn] |
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| Links: |
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| Themen: |
Anticoagulación |
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| Anmerkungen: |
Date Completed 15.11.2022 Date Revised 14.03.2023 published: Print-Electronic CommentIn: Med Clin (Barc). 2022 Nov 11;159(9):e61. - PMID 35933189 Citation Status MEDLINE |
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| doi: |
10.1016/j.medcli.2022.01.008 |
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| funding: |
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NLM338136614 |
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| 100 | 1 | |a Azaña Gómez, Javier |e verfasserin |4 aut | |
| 245 | 1 | 0 | |a Mortality risk factors in patients with SARS-CoV-2 infection and atrial fibrillation |b Data from the SEMI-COVID-19 registry |
| 246 | 3 | 3 | |a Factores de riesgo de mortalidad en pacientes con infección por SARS-CoV-2 y fibrilación auricular: datos del registro SEMI-COVID-19 |
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| 500 | |a Date Completed 15.11.2022 | ||
| 500 | |a Date Revised 14.03.2023 | ||
| 500 | |a published: Print-Electronic | ||
| 500 | |a CommentIn: Med Clin (Barc). 2022 Nov 11;159(9):e61. - PMID 35933189 | ||
| 500 | |a Citation Status MEDLINE | ||
| 520 | |a Copyright © 2022 Elsevier España, S.L.U. All rights reserved. | ||
| 520 | |a INTRODUCTION: Atrial fibrillation and associated comorbidities pose a risk factor for mortality, morbidity and development of complications in patients admitted for COVID-19 | ||
| 520 | |a OBJECTIVES: To describe the clinical, epidemiological, radiological and analytical characteristics of patients with atrial fibrillation admitted for COVID-19 in Spain. Secondarily, we aim to identify those variables associated with mortality and poor prognosis of COVID-19 in patients with atrial fibrillation | ||
| 520 | |a METHODS: Retrospective, observational, multicenter, nationwide, retrospective study of patients hospitalized for COVID-19 from March 1 to October 1, 2020. Data were obtained from the SEMI-COVID-19 Registry of the Spanish Society of Internal Medicine (SEMI) in which 150 Spanish hospitals participate | ||
| 520 | |a RESULTS: Between March 1 and October 1, 2020, data from a total of 16,461 patients were entered into the SEMI-COVID-19 registry. 1816 (11%) had a history of atrial fibrillation and the number of deaths among AF patients amounted to 738 (41%). Regarding clinical characteristics, deceased patients were admitted with a higher heart rate (88.38 vs. 84.95; P>0.01), with a higher percentage of respiratory failure (67.2 vs. 20.1%; P<0.01) and high tachypnea (58 vs. 30%; P<0.01). The comorbidities that presented statistically significant differences in the deceased group were: age, hypertension and diabetes with target organ involvement. There was also a higher prevalence of a history of cardiovascular disease in the deceased. On multivariate analysis, DOACs treatment had a protective role for mortality (OR: 0.597; CI: 0.402-0.888; P=0.011) | ||
| 520 | |a CONCLUSIONS: Previous treatment with DOACs and DOACs treatment during admission seem to have a protective role in patients with atrial fibrillation, although this fact should be verified in prospective studies | ||
| 650 | 4 | |a Multicenter Study | |
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a Anticoagulación | |
| 650 | 4 | |a Anticoagulation | |
| 650 | 4 | |a Atrial fibrillation | |
| 650 | 4 | |a COVID-19 | |
| 650 | 4 | |a Factor de riesgo | |
| 650 | 4 | |a Fibrilación auricular | |
| 650 | 4 | |a Hospitalización | |
| 650 | 4 | |a Hospitalization | |
| 650 | 4 | |a Mortalidad | |
| 650 | 4 | |a Mortality | |
| 650 | 4 | |a Risk factor | |
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| 700 | 1 | |a Rubio-Rivas, Manuel |e verfasserin |4 aut | |
| 700 | 1 | |a Bascuñana, José |e verfasserin |4 aut | |
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| 700 | 1 | |a Gómez-Huelgas, Ricardo |e verfasserin |4 aut | |
| 700 | 0 | |a en nombre del grupo SEMI-COVID-19 |e verfasserin |4 aut | |
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