Bacteraemia and quick Sepsis Related Organ Failure Assessment (qSOFA) are independent risk factors for long-term mortality in very elderly patients with suspected infection : retrospective cohort study
© 2022. The Author(s)..
BACKGROUND: In older adult patients, bloodstream infections cause significant mortality. However, data on long-term prognosis in very elderly patients are scarce. This study aims to assess 1-year mortality from bacteraemia in very elderly patients.
METHODS: Retrospective cohort study in inpatients aged 80 years or older and suspected of having sepsis. Patients with (n = 336) and without (n = 336) confirmed bacteraemia were matched for age, sex, and date of culture, and their characteristics were compared. All-cause mortality and risk of death were assessed using the adjusted hazard ratio (aHR).
RESULTS: Compared to controls, cases showed a higher 1-year mortality (34.8% vs. 45.2%) and mortality rate (0.46 vs. 0.69 deaths per person-year). Multivariable analysis showed significant risk of 1-year mortality in patients with bacteraemia (aHR: 1.31, 95% confidence interval [CI] 1.03-1.67), quick Sepsis Related Organ Failure Assessment (qSOFA) score of 2 or more (aHR: 2.71, 95% CI 2.05-3.57), and age of 90 years or older (aHR 1.53, 95% CI 1.17-1.99).
CONCLUSIONS: In elderly patients suspected of sepsis, bacteraemia is associated with a poor prognosis and higher long-term mortality. Other factors related to excess mortality were age over 90 years and a qSOFA score of 2 or more.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2022 |
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| Erschienen: |
2022 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:22 |
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| Enthalten in: |
BMC infectious diseases - 22(2022), 1 vom: 13. März, Seite 248 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Hernández-Quiles, Rubén [VerfasserIn] |
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| Anmerkungen: |
Date Completed 15.03.2022 Date Revised 18.03.2022 published: Electronic Citation Status MEDLINE |
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| doi: |
10.1186/s12879-022-07242-4 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM338098453 |
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| 245 | 1 | 0 | |a Bacteraemia and quick Sepsis Related Organ Failure Assessment (qSOFA) are independent risk factors for long-term mortality in very elderly patients with suspected infection |b retrospective cohort study |
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| 500 | |a Date Completed 15.03.2022 | ||
| 500 | |a Date Revised 18.03.2022 | ||
| 500 | |a published: Electronic | ||
| 500 | |a Citation Status MEDLINE | ||
| 520 | |a © 2022. The Author(s). | ||
| 520 | |a BACKGROUND: In older adult patients, bloodstream infections cause significant mortality. However, data on long-term prognosis in very elderly patients are scarce. This study aims to assess 1-year mortality from bacteraemia in very elderly patients | ||
| 520 | |a METHODS: Retrospective cohort study in inpatients aged 80 years or older and suspected of having sepsis. Patients with (n = 336) and without (n = 336) confirmed bacteraemia were matched for age, sex, and date of culture, and their characteristics were compared. All-cause mortality and risk of death were assessed using the adjusted hazard ratio (aHR) | ||
| 520 | |a RESULTS: Compared to controls, cases showed a higher 1-year mortality (34.8% vs. 45.2%) and mortality rate (0.46 vs. 0.69 deaths per person-year). Multivariable analysis showed significant risk of 1-year mortality in patients with bacteraemia (aHR: 1.31, 95% confidence interval [CI] 1.03-1.67), quick Sepsis Related Organ Failure Assessment (qSOFA) score of 2 or more (aHR: 2.71, 95% CI 2.05-3.57), and age of 90 years or older (aHR 1.53, 95% CI 1.17-1.99) | ||
| 520 | |a CONCLUSIONS: In elderly patients suspected of sepsis, bacteraemia is associated with a poor prognosis and higher long-term mortality. Other factors related to excess mortality were age over 90 years and a qSOFA score of 2 or more | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a Age ≥ 80 | |
| 650 | 4 | |a Bacteraemia | |
| 650 | 4 | |a Sepsis | |
| 650 | 4 | |a Survival | |
| 650 | 4 | |a qSOFA | |
| 700 | 1 | |a Merino-Lucas, Esperanza |e verfasserin |4 aut | |
| 700 | 1 | |a Boix, Vicente |e verfasserin |4 aut | |
| 700 | 1 | |a Fernández-Gil, Adela |e verfasserin |4 aut | |
| 700 | 1 | |a Rodríguez-Díaz, Juan C |e verfasserin |4 aut | |
| 700 | 1 | |a Gimeno, Adelina |e verfasserin |4 aut | |
| 700 | 1 | |a Valero, Beatriz |e verfasserin |4 aut | |
| 700 | 1 | |a Sánchez-Martínez, Rosario |e verfasserin |4 aut | |
| 700 | 1 | |a Ramos-Rincón, Jose-Manuel |e verfasserin |4 aut | |
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