One-stage versus two-stage piezocision-assisted orthodontic tooth movement : A preclinical study based on Nano-CT and RT-PCR analyses
Copyright © 2022. Published by Elsevier Masson SAS..
OBJECTIVE: To evaluate the effect of a second-stage piezocision on the biological response.
MATERIALS AND METHODS: 60 rats were randomly allocated to 6 experimental groups of 10 rats. Rats undergoing a one-stage piezocision were sacrified on day 7, 28 and 42 (groups 1-3) while rats undergoing a two-satge piezocision were sacrified on day 42, 63 and 90 (groups 4-6), respectively. The biological response was investigated in 3D at the tissue level using Nano-computed tomography (Nano-CT) and, at the molecular level using the qRT-PCR technique. Bone Volume Fraction (BVF) loss was the primary endpoint.
RESULTS: Similar loss of BVF were observed both after the first and second piezocisions. The change in BVF loss between 7 and 28 days after each piezocision were 25.1 ± 13.0 (SE)% and 11.2 ± 11.6 (SE)% respectively and did not differ from each other (p = 0.43). Changes in BVF loss from 7 to 42 days were also comparable in one-stage and two-stage piezocision (4.9 ± 12.3 (SE) vs. -19.9 ± 13.4 (SE), p = 0.19). At the molecular level, all parameters except Translating Ribosome Affinity Purification (TRAP) protein had identical patterns.
CONCLUSION: Within the limits of the present study, a second piezocision allowed to re-induce the Regional Acceleratory Phenomenon (RAP) effect. Nevertheless, the relevance of the findings to the clinical effect has not been tested.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2022 |
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| Erschienen: |
2022 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:123 |
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| Enthalten in: |
Journal of stomatology, oral and maxillofacial surgery - 123(2022), 6 vom: 12. Nov., Seite e663-e669 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Charavet, Carole [VerfasserIn] |
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| Links: |
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| Themen: |
Accelerated orthodontics |
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| Anmerkungen: |
Date Completed 01.11.2022 Date Revised 27.02.2023 published: Print-Electronic Citation Status MEDLINE |
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| doi: |
10.1016/j.jormas.2022.03.010 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM338072217 |
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| 245 | 1 | 0 | |a One-stage versus two-stage piezocision-assisted orthodontic tooth movement |b A preclinical study based on Nano-CT and RT-PCR analyses |
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| 500 | |a Date Completed 01.11.2022 | ||
| 500 | |a Date Revised 27.02.2023 | ||
| 500 | |a published: Print-Electronic | ||
| 500 | |a Citation Status MEDLINE | ||
| 520 | |a Copyright © 2022. Published by Elsevier Masson SAS. | ||
| 520 | |a OBJECTIVE: To evaluate the effect of a second-stage piezocision on the biological response | ||
| 520 | |a MATERIALS AND METHODS: 60 rats were randomly allocated to 6 experimental groups of 10 rats. Rats undergoing a one-stage piezocision were sacrified on day 7, 28 and 42 (groups 1-3) while rats undergoing a two-satge piezocision were sacrified on day 42, 63 and 90 (groups 4-6), respectively. The biological response was investigated in 3D at the tissue level using Nano-computed tomography (Nano-CT) and, at the molecular level using the qRT-PCR technique. Bone Volume Fraction (BVF) loss was the primary endpoint | ||
| 520 | |a RESULTS: Similar loss of BVF were observed both after the first and second piezocisions. The change in BVF loss between 7 and 28 days after each piezocision were 25.1 ± 13.0 (SE)% and 11.2 ± 11.6 (SE)% respectively and did not differ from each other (p = 0.43). Changes in BVF loss from 7 to 42 days were also comparable in one-stage and two-stage piezocision (4.9 ± 12.3 (SE) vs. -19.9 ± 13.4 (SE), p = 0.19). At the molecular level, all parameters except Translating Ribosome Affinity Purification (TRAP) protein had identical patterns | ||
| 520 | |a CONCLUSION: Within the limits of the present study, a second piezocision allowed to re-induce the Regional Acceleratory Phenomenon (RAP) effect. Nevertheless, the relevance of the findings to the clinical effect has not been tested | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a Accelerated orthodontics | |
| 650 | 4 | |a Corticotomy | |
| 650 | 4 | |a Piezocision | |
| 650 | 4 | |a Piezosurgery | |
| 650 | 4 | |a Regional acceleratory phenomenon | |
| 700 | 1 | |a Van Hede, Dorien |e verfasserin |4 aut | |
| 700 | 1 | |a Anania, Sandy |e verfasserin |4 aut | |
| 700 | 1 | |a Maes, Nathalie |e verfasserin |4 aut | |
| 700 | 1 | |a Albert, Adelin |e verfasserin |4 aut | |
| 700 | 1 | |a Lambert, France |e verfasserin |4 aut | |
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