Post COVID-19 Myelin Oligodendrocyte Glycoprotein Antibody-Associated Optic Neuritis
© 2021 Taylor & Francis Group, LLC..
Neurological manifestations of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) are relatively common. Although some may be consequences of direct cellular viral invasion (neurotropism), many represent post-infectious inflammation mediated by autoimmune mechanisms. We herein report the case of a 69-year-old diabetic male who presented with bilateral sub-acute, progressive loss of vision 45 days after suffering a presumed SARS-CoV-2 related pneumonia. He had bilateral optic disc oedema. Magnetic resonance imaging showed uniform contrast enhancement of both optic nerves without spinal cord involvement. He tested positive for SARS-CoV-2 IgG and myelin oligodendrocyte glycoprotein (MOG) IgG antibodies. He was treated with intravenous methylprednisolone for 5 days. The optic disc oedema resolved within 6 weeks with improvement in visual acuity, although optic atrophy developed by week 16. The MOG-IgG antibody test turned negative after 24 weeks.
Medienart: |
E-Artikel |
---|
Erscheinungsjahr: |
2022 |
---|---|
Erschienen: |
2022 |
Enthalten in: |
Zur Gesamtaufnahme - volume:46 |
---|---|
Enthalten in: |
Neuro-ophthalmology (Aeolus Press) - 46(2022), 2 vom: 25., Seite 115-121 |
Sprache: |
Englisch |
---|
Beteiligte Personen: |
Rojas-Correa, Daniela Ximena [VerfasserIn] |
---|
Links: |
---|
Themen: |
COVID-19 |
---|
Anmerkungen: |
Date Revised 16.07.2022 published: Electronic-eCollection Citation Status PubMed-not-MEDLINE |
---|
doi: |
10.1080/01658107.2021.1916044 |
---|
funding: |
|
---|---|
Förderinstitution / Projekttitel: |
|
PPN (Katalog-ID): |
NLM338042520 |
---|
LEADER | 01000naa a22002652 4500 | ||
---|---|---|---|
001 | NLM338042520 | ||
003 | DE-627 | ||
005 | 20231225235758.0 | ||
007 | cr uuu---uuuuu | ||
008 | 231225s2022 xx |||||o 00| ||eng c | ||
024 | 7 | |a 10.1080/01658107.2021.1916044 |2 doi | |
028 | 5 | 2 | |a pubmed24n1126.xml |
035 | |a (DE-627)NLM338042520 | ||
035 | |a (NLM)35273416 | ||
040 | |a DE-627 |b ger |c DE-627 |e rakwb | ||
041 | |a eng | ||
100 | 1 | |a Rojas-Correa, Daniela Ximena |e verfasserin |4 aut | |
245 | 1 | 0 | |a Post COVID-19 Myelin Oligodendrocyte Glycoprotein Antibody-Associated Optic Neuritis |
264 | 1 | |c 2022 | |
336 | |a Text |b txt |2 rdacontent | ||
337 | |a ƒaComputermedien |b c |2 rdamedia | ||
338 | |a ƒa Online-Ressource |b cr |2 rdacarrier | ||
500 | |a Date Revised 16.07.2022 | ||
500 | |a published: Electronic-eCollection | ||
500 | |a Citation Status PubMed-not-MEDLINE | ||
520 | |a © 2021 Taylor & Francis Group, LLC. | ||
520 | |a Neurological manifestations of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) are relatively common. Although some may be consequences of direct cellular viral invasion (neurotropism), many represent post-infectious inflammation mediated by autoimmune mechanisms. We herein report the case of a 69-year-old diabetic male who presented with bilateral sub-acute, progressive loss of vision 45 days after suffering a presumed SARS-CoV-2 related pneumonia. He had bilateral optic disc oedema. Magnetic resonance imaging showed uniform contrast enhancement of both optic nerves without spinal cord involvement. He tested positive for SARS-CoV-2 IgG and myelin oligodendrocyte glycoprotein (MOG) IgG antibodies. He was treated with intravenous methylprednisolone for 5 days. The optic disc oedema resolved within 6 weeks with improvement in visual acuity, although optic atrophy developed by week 16. The MOG-IgG antibody test turned negative after 24 weeks | ||
650 | 4 | |a Case Reports | |
650 | 4 | |a COVID-19 | |
650 | 4 | |a SARS-CoV-2 | |
650 | 4 | |a myelin oligodendrocyte glycoprotein (MOG) | |
650 | 4 | |a optic neuritis | |
700 | 1 | |a Reche-Sainz, José Alberto |e verfasserin |4 aut | |
700 | 1 | |a Insausti-García, Alfredo |e verfasserin |4 aut | |
700 | 1 | |a Calleja-García, Cristina |e verfasserin |4 aut | |
700 | 1 | |a Ferro-Osuna, Manuel |e verfasserin |4 aut | |
773 | 0 | 8 | |i Enthalten in |t Neuro-ophthalmology (Aeolus Press) |d 1987 |g 46(2022), 2 vom: 25., Seite 115-121 |w (DE-627)NLM083836187 |x 0165-8107 |7 nnns |
773 | 1 | 8 | |g volume:46 |g year:2022 |g number:2 |g day:25 |g pages:115-121 |
856 | 4 | 0 | |u http://dx.doi.org/10.1080/01658107.2021.1916044 |3 Volltext |
912 | |a GBV_USEFLAG_A | ||
912 | |a GBV_NLM | ||
951 | |a AR | ||
952 | |d 46 |j 2022 |e 2 |b 25 |h 115-121 |