Clinical Outcomes in Patients Aged 80 Years or Older Receiving Non-Invasive Respiratory Support for Hypoxemic Acute Respiratory Failure Consequent to COVID-19
As the clinical outcome of octogenarian patients hospitalised for COVID-19 is very poor, here we assessed the clinical characteristics and outcomes of patients aged 80 year or older hospitalised for COVID-19 receiving non-invasive respiratory support (NIRS). A multicentre, retrospective, observational study was conducted in seven hospitals in Northern Italy. All patients aged ≥80 years with COVID-19 associated hypoxemic acute respiratory failure (hARF) undergoing NIRS between 24 February 2020, and 31 March 2021, were included. Out of 252 study participants, 156 (61.9%) and 163 (64.6%) died during hospital stay and within 90 days from hospital admission, respectively. In this case, 228 (90.5%) patients only received NIRS (NIRS group), while 24 (9.5%) were treated with invasive mechanical ventilation (IMV) after NIRS failure (NIRS+IMV group). In-hospital mortality did not significantly differ between NIRS and NIRS+IMV group (61.0% vs. 70.8%, respectively; p = 0.507), while survival probability at 90 days was significantly higher for NIRS compared to NIRS+IMV patients (0.379 vs. 0.147; p = 0.0025). The outcome of octogenarian patients with COVID-19 receiving NIRS is quite poor. Caution should be used when considering transition from NIRS to IMV after NIRS failure.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2022 |
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| Erschienen: |
2022 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:11 |
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| Enthalten in: |
Journal of clinical medicine - 11(2022), 5 vom: 02. März |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Vianello, Andrea [VerfasserIn] |
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| Links: |
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| Themen: |
Acute respiratory failure |
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| Anmerkungen: |
Date Revised 16.03.2022 published: Electronic Citation Status PubMed-not-MEDLINE |
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| doi: |
10.3390/jcm11051372 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM337993114 |
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| 520 | |a As the clinical outcome of octogenarian patients hospitalised for COVID-19 is very poor, here we assessed the clinical characteristics and outcomes of patients aged 80 year or older hospitalised for COVID-19 receiving non-invasive respiratory support (NIRS). A multicentre, retrospective, observational study was conducted in seven hospitals in Northern Italy. All patients aged ≥80 years with COVID-19 associated hypoxemic acute respiratory failure (hARF) undergoing NIRS between 24 February 2020, and 31 March 2021, were included. Out of 252 study participants, 156 (61.9%) and 163 (64.6%) died during hospital stay and within 90 days from hospital admission, respectively. In this case, 228 (90.5%) patients only received NIRS (NIRS group), while 24 (9.5%) were treated with invasive mechanical ventilation (IMV) after NIRS failure (NIRS+IMV group). In-hospital mortality did not significantly differ between NIRS and NIRS+IMV group (61.0% vs. 70.8%, respectively; p = 0.507), while survival probability at 90 days was significantly higher for NIRS compared to NIRS+IMV patients (0.379 vs. 0.147; p = 0.0025). The outcome of octogenarian patients with COVID-19 receiving NIRS is quite poor. Caution should be used when considering transition from NIRS to IMV after NIRS failure | ||
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| 700 | 1 | |a De Vita, Nello |e verfasserin |4 aut | |
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| 700 | 1 | |a Confalonieri, Marco |e verfasserin |4 aut | |
| 700 | 1 | |a Bonato, Valeria |e verfasserin |4 aut | |
| 700 | 1 | |a Molena, Beatrice |e verfasserin |4 aut | |
| 700 | 1 | |a Maestrone, Carlo |e verfasserin |4 aut | |
| 700 | 1 | |a Airoldi, Gianluca |e verfasserin |4 aut | |
| 700 | 1 | |a Olivieri, Carlo |e verfasserin |4 aut | |
| 700 | 1 | |a Sainaghi, Pier Paolo |e verfasserin |4 aut | |
| 700 | 1 | |a Lionello, Federico |e verfasserin |4 aut | |
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| 700 | 1 | |a Della Corte, Francesco |e verfasserin |4 aut | |
| 700 | 1 | |a Navalesi, Paolo |e verfasserin |4 aut | |
| 700 | 1 | |a Vaschetto, Rosanna |e verfasserin |4 aut | |
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