Case series of HIV SARS-CoV-2 co-infection in Chinese adults
© 2022 The Authors. Published by Elsevier Ltd..
Objectives: Little is known whether differences exist in virus shedding, immune and inflammatory response related to SARS-CoV-2 in people living with human immunodeficiency virus (PLWH). We assessed viral RNA and cytokine profiles of HIV and SARS-CoV-2 coinfection in Hong Kong.
Methods: PLWH hospitalized with SARS-CoV-2 infection in Hong Kong were included, compared with age-matched and disease severity-matched SARS-CoV-2 infected controls (ratio of 1:5) from February 1st 2020 to July 31st 2020. SARS-CoV-2 infection was confirmed by public health laboratory and virus concentration was quantified by an in-house real-time reverse transcription-quantitative polymerase chain reaction. A panel of cytokines and chemokines were performed.
Results: HIV patients had a similar respiratory shedding profile compared to controls. Duration of faecal shedding of patient A, B, C and D were at least 9, 10, 33, and 11 days, respectively. HIV patients had lower plasma levels of IL-10 and NT-pro-BNP. All 4 PLWH cases showed seroconversion to SARS-CoV-2 with anti-SARS-CoV-2 S antibodies detected in serum collected between day 18 and 30 after symptom onset.
Conclusions: PLWH behaves similarly with HIV-negative controls in respiratory viral load, but with decrease in IL-10 and NT-proBNP. PLWH may have a lower risk of immunostimulatory effect due to lower IL-10.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2022 |
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| Erschienen: |
2022 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:2 |
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| Enthalten in: |
Journal of clinical virology plus - 2(2022), 1 vom: 08. Feb., Seite 100062 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Ng, Rita Wai-Yin [VerfasserIn] |
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| Links: |
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| Themen: |
Adults |
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| Anmerkungen: |
Date Revised 10.03.2022 published: Print-Electronic Citation Status PubMed-not-MEDLINE |
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| doi: |
10.1016/j.jcvp.2022.100062 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM337929408 |
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| 245 | 1 | 0 | |a Case series of HIV SARS-CoV-2 co-infection in Chinese adults |
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| 500 | |a published: Print-Electronic | ||
| 500 | |a Citation Status PubMed-not-MEDLINE | ||
| 520 | |a © 2022 The Authors. Published by Elsevier Ltd. | ||
| 520 | |a Objectives: Little is known whether differences exist in virus shedding, immune and inflammatory response related to SARS-CoV-2 in people living with human immunodeficiency virus (PLWH). We assessed viral RNA and cytokine profiles of HIV and SARS-CoV-2 coinfection in Hong Kong | ||
| 520 | |a Methods: PLWH hospitalized with SARS-CoV-2 infection in Hong Kong were included, compared with age-matched and disease severity-matched SARS-CoV-2 infected controls (ratio of 1:5) from February 1st 2020 to July 31st 2020. SARS-CoV-2 infection was confirmed by public health laboratory and virus concentration was quantified by an in-house real-time reverse transcription-quantitative polymerase chain reaction. A panel of cytokines and chemokines were performed | ||
| 520 | |a Results: HIV patients had a similar respiratory shedding profile compared to controls. Duration of faecal shedding of patient A, B, C and D were at least 9, 10, 33, and 11 days, respectively. HIV patients had lower plasma levels of IL-10 and NT-pro-BNP. All 4 PLWH cases showed seroconversion to SARS-CoV-2 with anti-SARS-CoV-2 S antibodies detected in serum collected between day 18 and 30 after symptom onset | ||
| 520 | |a Conclusions: PLWH behaves similarly with HIV-negative controls in respiratory viral load, but with decrease in IL-10 and NT-proBNP. PLWH may have a lower risk of immunostimulatory effect due to lower IL-10 | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a Adults | |
| 650 | 4 | |a COVID-19 | |
| 650 | 4 | |a Coinfection | |
| 650 | 4 | |a Human immunodeficiency virus | |
| 650 | 4 | |a Severe respiratory syndrome coronavirus 2 | |
| 700 | 1 | |a Wong, Chun-Kwok |e verfasserin |4 aut | |
| 700 | 1 | |a Lui, Grace Chung-Yan |e verfasserin |4 aut | |
| 700 | 1 | |a Tso, Eugene Yuk-Keung |e verfasserin |4 aut | |
| 700 | 1 | |a Chen, Zigui |e verfasserin |4 aut | |
| 700 | 1 | |a Tsang, Owen Tak-Yin |e verfasserin |4 aut | |
| 700 | 1 | |a Boon, Siaw Shi |e verfasserin |4 aut | |
| 700 | 1 | |a Lai, Christopher Koon-Chi |e verfasserin |4 aut | |
| 700 | 1 | |a Fung, Kitty Sau-Chun |e verfasserin |4 aut | |
| 700 | 1 | |a Yeung, Apple Chung-Man |e verfasserin |4 aut | |
| 700 | 1 | |a Ho, Wendy Ching-Sze |e verfasserin |4 aut | |
| 700 | 1 | |a Hui, David Shu-Cheong |e verfasserin |4 aut | |
| 700 | 1 | |a Chan, Paul Kay-Sheung |e verfasserin |4 aut | |
| 700 | 1 | |a Chan, Jacky Man-Chun |e verfasserin |4 aut | |
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