Efficacy of careHPV™ human papillomavirus screening versus conventional cytology tests for the detection of precancerous and cancerous cervical lesions among women living with HIV-1 in Lao People's Democratic Republic
© 2022 The Authors. Cancer Medicine published by John Wiley & Sons Ltd..
BACKGROUND: In the Lao People's Democratic Republic (Lao PDR), cervical cancer is the third leading cause of women cancer.
AIMS: The objective of this cross-sectional study was to compare the efficacy of careHPV™ test versus conventional Pap smear or Siriraj liquid-based cytology in the detection of cervical cancer in women living with human immunodeficiency virus type 1 (HIV-1).
MATERIALS & METHODS: Overall, 631 women consented to participate. Four cervical specimens were taken for the purpose of conventional Pap smear, Siriraj liquid-based cytology, careHPV™ test, and HPV-16 genotyping. The exact McNemar test was used to compare the efficacy and diagnostic performance of the tests.
RESULTS: Of the 631 women with follow-up, 331 were human papillomavirus (HPV) negative. High-grade squamous intraepithelial lesions were found in 37 women, biopsy-proven high-grade cervical intraepithelial neoplasia in 50 women, and invasive carcinoma in seven women. The proportion of women with high-grade cervical lesion or carcinoma detected after abnormal careHPV™ test was higher (6.02%; 95% confidence interval [CI]: 4.4-8.1) than that detected by conventional Pap smear (4.59%; 95% CI: 3.2-6.5). careHPV™ and HPV-16 genotyping had, respectively, the highest sensitivity (80.8%; 95% CI: 67.4-89.5) and specificity (92.2%; 95% CI: 89.8-94.2). HPV-16 was the most frequently detected genotype.
CONCLUSIONS: careHPV™ test represents a screening option in Lao PDR, particularly in women living with HIV-1 because of higher prevalence of chronic HPV in this population.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2022 |
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| Erschienen: |
2022 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:11 |
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| Enthalten in: |
Cancer medicine - 11(2022), 9 vom: 07. Mai, Seite 1984-1994 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Paboriboune, Phimpha [VerfasserIn] |
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| Links: |
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| Themen: |
CareHPV™ |
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| Anmerkungen: |
Date Completed 12.05.2022 Date Revised 16.09.2023 published: Print-Electronic Citation Status MEDLINE |
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| doi: |
10.1002/cam4.4502 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| 100 | 1 | |a Paboriboune, Phimpha |e verfasserin |4 aut | |
| 245 | 1 | 0 | |a Efficacy of careHPV™ human papillomavirus screening versus conventional cytology tests for the detection of precancerous and cancerous cervical lesions among women living with HIV-1 in Lao People's Democratic Republic |
| 264 | 1 | |c 2022 | |
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| 500 | |a Date Completed 12.05.2022 | ||
| 500 | |a Date Revised 16.09.2023 | ||
| 500 | |a published: Print-Electronic | ||
| 500 | |a Citation Status MEDLINE | ||
| 520 | |a © 2022 The Authors. Cancer Medicine published by John Wiley & Sons Ltd. | ||
| 520 | |a BACKGROUND: In the Lao People's Democratic Republic (Lao PDR), cervical cancer is the third leading cause of women cancer | ||
| 520 | |a AIMS: The objective of this cross-sectional study was to compare the efficacy of careHPV™ test versus conventional Pap smear or Siriraj liquid-based cytology in the detection of cervical cancer in women living with human immunodeficiency virus type 1 (HIV-1) | ||
| 520 | |a MATERIALS & METHODS: Overall, 631 women consented to participate. Four cervical specimens were taken for the purpose of conventional Pap smear, Siriraj liquid-based cytology, careHPV™ test, and HPV-16 genotyping. The exact McNemar test was used to compare the efficacy and diagnostic performance of the tests | ||
| 520 | |a RESULTS: Of the 631 women with follow-up, 331 were human papillomavirus (HPV) negative. High-grade squamous intraepithelial lesions were found in 37 women, biopsy-proven high-grade cervical intraepithelial neoplasia in 50 women, and invasive carcinoma in seven women. The proportion of women with high-grade cervical lesion or carcinoma detected after abnormal careHPV™ test was higher (6.02%; 95% confidence interval [CI]: 4.4-8.1) than that detected by conventional Pap smear (4.59%; 95% CI: 3.2-6.5). careHPV™ and HPV-16 genotyping had, respectively, the highest sensitivity (80.8%; 95% CI: 67.4-89.5) and specificity (92.2%; 95% CI: 89.8-94.2). HPV-16 was the most frequently detected genotype | ||
| 520 | |a CONCLUSIONS: careHPV™ test represents a screening option in Lao PDR, particularly in women living with HIV-1 because of higher prevalence of chronic HPV in this population | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a Research Support, Non-U.S. Gov't | |
| 650 | 4 | |a HIV-1 | |
| 650 | 4 | |a Lao PDR | |
| 650 | 4 | |a Papanicolaou test | |
| 650 | 4 | |a careHPV™ | |
| 650 | 4 | |a cervical cancer | |
| 650 | 4 | |a liquid-based cytology | |
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| 700 | 1 | |a Arounlangsy, Phetsamone |e verfasserin |4 aut | |
| 700 | 1 | |a Flaissier, Bruno |e verfasserin |4 aut | |
| 700 | 1 | |a Aphayarath, Oukham |e verfasserin |4 aut | |
| 700 | 1 | |a Phimmasone, Prasit |e verfasserin |4 aut | |
| 700 | 1 | |a Banchongphanith, Ketmala |e verfasserin |4 aut | |
| 700 | 1 | |a Xayaovong, Mixi |e verfasserin |4 aut | |
| 700 | 1 | |a Jourdain, Gonzague |e verfasserin |4 aut | |
| 700 | 1 | |a Schott, Anne-Marie |e verfasserin |4 aut | |
| 700 | 1 | |a Saadatian-Elahi, Mitra |e verfasserin |4 aut | |
| 700 | 1 | |a Magaud, Laurent |e verfasserin |4 aut | |
| 700 | 1 | |a Klich, Amna |e verfasserin |4 aut | |
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| 700 | 1 | |a Rabilloud, Muriel |e verfasserin |4 aut | |
| 700 | 1 | |a Picot, Valentina Sanchez |e verfasserin |4 aut | |
| 700 | 1 | |a Longuet, Christophe |e verfasserin |4 aut | |
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