Mitochondria-lysosome contact site dynamics and misregulation in neurodegenerative diseases
Copyright © 2022 Elsevier Ltd. All rights reserved..
Neurons rely heavily on properly regulated mitochondrial and lysosomal homeostasis, with multiple neurodegenerative diseases linked to dysfunction in these two organelles. Interestingly, mitochondria-lysosome membrane contact sites have been identified as a key pathway mediating their crosstalk in neurons. Recent studies have further elucidated the regulation of mitochondria-lysosome contact dynamics via distinct tethering/untethering protein machinery. Moreover, this pathway has been shown to have additional functions in regulating organelle network dynamics and metabolite transfer between lysosomes and mitochondria. In this review, we highlight recent advances in the field of mitochondria-lysosome contact sites and their misregulation across multiple neurodegenerative disorders, which further underscore a potential role for this pathway in neuronal homeostasis and disease.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2022 |
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| Erschienen: |
2022 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:45 |
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| Enthalten in: |
Trends in neurosciences - 45(2022), 4 vom: 04. Apr., Seite 312-322 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Cisneros, Jasmine [VerfasserIn] |
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| Links: |
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| Themen: |
Charcot-Marie-Tooth disease |
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| Anmerkungen: |
Date Completed 07.04.2022 Date Revised 02.04.2023 published: Print Citation Status MEDLINE |
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| doi: |
10.1016/j.tins.2022.01.005 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM337808074 |
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| 520 | |a Neurons rely heavily on properly regulated mitochondrial and lysosomal homeostasis, with multiple neurodegenerative diseases linked to dysfunction in these two organelles. Interestingly, mitochondria-lysosome membrane contact sites have been identified as a key pathway mediating their crosstalk in neurons. Recent studies have further elucidated the regulation of mitochondria-lysosome contact dynamics via distinct tethering/untethering protein machinery. Moreover, this pathway has been shown to have additional functions in regulating organelle network dynamics and metabolite transfer between lysosomes and mitochondria. In this review, we highlight recent advances in the field of mitochondria-lysosome contact sites and their misregulation across multiple neurodegenerative disorders, which further underscore a potential role for this pathway in neuronal homeostasis and disease | ||
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| 700 | 1 | |a Molakal, Catherine G |e verfasserin |4 aut | |
| 700 | 1 | |a Wong, Yvette C |e verfasserin |4 aut | |
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