Acute hepatitis B among HIV positive persons : A two-decade review of cases from a Spanish cohort
Copyright © 2020 Sociedad Española de Enfermedades Infecciosas y Microbiología Clínica. Published by Elsevier España, S.L.U. All rights reserved..
PURPOSE: To review the incidence and characteristics of acute hepatitis B (AHB) in a large cohort of HIV infected persons from a low prevalence region during the last two decades.
METHODS: Retrospective review of an HIV Cohort from a single reference centre in Madrid, Spain, between 2000 and 2018. AHB was diagnosed in persons with newly acquired HBAgS and acute hepatitis with positive IgM anti-HBc.
RESULTS: Out of 5443 HIV+ patients in our cohort (3098 anti-HBc negative), 18 developed AHB from 2000 to 2018. The global incidence was 0.02 (0.01-0.04) per 100 patient-year in the entire population and 0.06 (0.01-0.1) per 100 patient-year in the anti-HBc negative population. A statistically significant decrease in AHB incidence was observed during these years (β=-0.006; p=0.047). All 18 patients diagnosed with AHB were men, the majority (16) occurred in men who have sex with men. AHB was observed in 4 persons previously unresponsive to vaccination. Regarding antiretroviral treatment (ART), 15 were not receiving ART, two persons were on ART with any HBV active drugs and one person had lamivudine in the regimen. Two persons (11%) developed chronic hepatitis B. There were no cases of fulminant hepatitis.
CONCLUSION: The incidence of AHB in HIV positive persons in our cohort was low and shows a progressive decline in the last 20 years. Cases occurred in persons not protected against VHB: not vaccinated or non-responders to vaccine that were not receiving tenofovir.
| Medienart: |
E-Artikel |
|---|
| Erscheinungsjahr: |
2022 |
|---|---|
| Erschienen: |
2022 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:40 |
|---|---|
| Enthalten in: |
Enfermedades infecciosas y microbiologia clinica (English ed.) - 40(2022), 3 vom: 14. März, Seite 121-124 |
| Sprache: |
Englisch |
|---|
| Beteiligte Personen: |
Martín-Carbonero, Luz [VerfasserIn] |
|---|
| Links: |
|---|
| Themen: |
Acute hepatitis B |
|---|
| Anmerkungen: |
Date Completed 09.03.2022 Date Revised 31.05.2022 published: Print Citation Status MEDLINE |
|---|
| doi: |
10.1016/j.eimce.2020.09.008 |
|---|
| funding: |
|
|---|---|
| Förderinstitution / Projekttitel: |
|
| PPN (Katalog-ID): |
NLM337807345 |
|---|
| LEADER | 01000naa a22002652 4500 | ||
|---|---|---|---|
| 001 | NLM337807345 | ||
| 003 | DE-627 | ||
| 005 | 20231225235242.0 | ||
| 007 | cr uuu---uuuuu | ||
| 008 | 231225s2022 xx |||||o 00| ||eng c | ||
| 024 | 7 | |a 10.1016/j.eimce.2020.09.008 |2 doi | |
| 028 | 5 | 2 | |a pubmed24n1125.xml |
| 035 | |a (DE-627)NLM337807345 | ||
| 035 | |a (NLM)35249671 | ||
| 035 | |a (PII)S2529-993X(22)00023-5 | ||
| 040 | |a DE-627 |b ger |c DE-627 |e rakwb | ||
| 041 | |a eng | ||
| 100 | 1 | |a Martín-Carbonero, Luz |e verfasserin |4 aut | |
| 245 | 1 | 0 | |a Acute hepatitis B among HIV positive persons |b A two-decade review of cases from a Spanish cohort |
| 264 | 1 | |c 2022 | |
| 336 | |a Text |b txt |2 rdacontent | ||
| 337 | |a ƒaComputermedien |b c |2 rdamedia | ||
| 338 | |a ƒa Online-Ressource |b cr |2 rdacarrier | ||
| 500 | |a Date Completed 09.03.2022 | ||
| 500 | |a Date Revised 31.05.2022 | ||
| 500 | |a published: Print | ||
| 500 | |a Citation Status MEDLINE | ||
| 520 | |a Copyright © 2020 Sociedad Española de Enfermedades Infecciosas y Microbiología Clínica. Published by Elsevier España, S.L.U. All rights reserved. | ||
| 520 | |a PURPOSE: To review the incidence and characteristics of acute hepatitis B (AHB) in a large cohort of HIV infected persons from a low prevalence region during the last two decades | ||
| 520 | |a METHODS: Retrospective review of an HIV Cohort from a single reference centre in Madrid, Spain, between 2000 and 2018. AHB was diagnosed in persons with newly acquired HBAgS and acute hepatitis with positive IgM anti-HBc | ||
| 520 | |a RESULTS: Out of 5443 HIV+ patients in our cohort (3098 anti-HBc negative), 18 developed AHB from 2000 to 2018. The global incidence was 0.02 (0.01-0.04) per 100 patient-year in the entire population and 0.06 (0.01-0.1) per 100 patient-year in the anti-HBc negative population. A statistically significant decrease in AHB incidence was observed during these years (β=-0.006; p=0.047). All 18 patients diagnosed with AHB were men, the majority (16) occurred in men who have sex with men. AHB was observed in 4 persons previously unresponsive to vaccination. Regarding antiretroviral treatment (ART), 15 were not receiving ART, two persons were on ART with any HBV active drugs and one person had lamivudine in the regimen. Two persons (11%) developed chronic hepatitis B. There were no cases of fulminant hepatitis | ||
| 520 | |a CONCLUSION: The incidence of AHB in HIV positive persons in our cohort was low and shows a progressive decline in the last 20 years. Cases occurred in persons not protected against VHB: not vaccinated or non-responders to vaccine that were not receiving tenofovir | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a Review | |
| 650 | 4 | |a Acute hepatitis B | |
| 650 | 4 | |a HIV | |
| 650 | 4 | |a Hepatitis B aguda | |
| 650 | 4 | |a Tenofovir | |
| 650 | 4 | |a VIH | |
| 650 | 4 | |a Vaccines | |
| 650 | 4 | |a Vacunas | |
| 650 | 7 | |a Hepatitis B Antibodies |2 NLM | |
| 700 | 1 | |a de Miguel, Rosa |e verfasserin |4 aut | |
| 700 | 1 | |a Serrano, Lucía |e verfasserin |4 aut | |
| 700 | 1 | |a Bernardino, Jose I |e verfasserin |4 aut | |
| 700 | 1 | |a Valencia, Eulalia |e verfasserin |4 aut | |
| 700 | 1 | |a Busca, Carmen |e verfasserin |4 aut | |
| 700 | 1 | |a Micán, Rafael |e verfasserin |4 aut | |
| 700 | 1 | |a Montejano, Rocío |e verfasserin |4 aut | |
| 700 | 1 | |a Moreno, Victoria |e verfasserin |4 aut | |
| 700 | 1 | |a Pérez-Valero, Ignacio |e verfasserin |4 aut | |
| 700 | 1 | |a Arribas, Jose Ramón |e verfasserin |4 aut | |
| 700 | 1 | |a González-García, Juan |e verfasserin |4 aut | |
| 700 | 1 | |a Montes, Marisa |e verfasserin |4 aut | |
| 773 | 0 | 8 | |i Enthalten in |t Enfermedades infecciosas y microbiologia clinica (English ed.) |d 2012 |g 40(2022), 3 vom: 14. März, Seite 121-124 |w (DE-627)NLM220666776 |x 2529-993X |7 nnns |
| 773 | 1 | 8 | |g volume:40 |g year:2022 |g number:3 |g day:14 |g month:03 |g pages:121-124 |
| 856 | 4 | 0 | |u http://dx.doi.org/10.1016/j.eimce.2020.09.008 |3 Volltext |
| 912 | |a GBV_USEFLAG_A | ||
| 912 | |a GBV_NLM | ||
| 951 | |a AR | ||
| 952 | |d 40 |j 2022 |e 3 |b 14 |c 03 |h 121-124 | ||