Nanoemulsions for enhanced skin permeation and controlled delivery of chlorohexidine digluconate
Chlorhexidine digluconate (CHG) is a widely used antiseptic for skin disinfection, as it exhibits poor skin permeability. Therefore, aim of the present study was preparation and evaluation of CHG nanoemulsions (NEs) using high-speed homogenisation (HSH) combined with ultra-probe sonication to improve skin permeability. CHG-NEs were prepared using eucalyptus oil (EO) and olive oil (OO), with a surfactant-to-cosurfactant ratio of 2:1. Optimised NEs had a mean droplet diameter of 257.5 ± 12.4 nm and PDI of 0.56 ± 0.13. In In vitro permeation studies EO based NEs delivered more CHG into the skin, 6.15 ± 0.12 µg/mg compared to 3.01 ± 0.02 µg/mg for a control solution. Additionally NEs were incorporated into an in situ forming dressing and results showed controlled delivery of CHG within skin. Together, these findings bring new possibilities for topical antimicrobial treatment and prophylactic strategies in wound management.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2022 |
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| Erschienen: |
2022 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:39 |
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| Enthalten in: |
Journal of microencapsulation - 39(2022), 2 vom: 07. März, Seite 110-124 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Kakadia, Pratibha G [VerfasserIn] |
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| Links: |
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| Themen: |
Anti-Bacterial Agents |
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| Anmerkungen: |
Date Completed 20.06.2022 Date Revised 20.06.2022 published: Print-Electronic Citation Status MEDLINE |
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| doi: |
10.1080/02652048.2022.2050318 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM337805105 |
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| 520 | |a Chlorhexidine digluconate (CHG) is a widely used antiseptic for skin disinfection, as it exhibits poor skin permeability. Therefore, aim of the present study was preparation and evaluation of CHG nanoemulsions (NEs) using high-speed homogenisation (HSH) combined with ultra-probe sonication to improve skin permeability. CHG-NEs were prepared using eucalyptus oil (EO) and olive oil (OO), with a surfactant-to-cosurfactant ratio of 2:1. Optimised NEs had a mean droplet diameter of 257.5 ± 12.4 nm and PDI of 0.56 ± 0.13. In In vitro permeation studies EO based NEs delivered more CHG into the skin, 6.15 ± 0.12 µg/mg compared to 3.01 ± 0.02 µg/mg for a control solution. Additionally NEs were incorporated into an in situ forming dressing and results showed controlled delivery of CHG within skin. Together, these findings bring new possibilities for topical antimicrobial treatment and prophylactic strategies in wound management | ||
| 650 | 4 | |a Journal Article | |
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