Epidemiology of familial multiple sclerosis in Iran : a national registry-based study
© 2022. The Author(s)..
BACKGROUND: Admittedly, little is known about the epidemiological signatures of familial multiple sclerosis (FMS) in different geographical regions of Iran.
OBJECTIVE: To determine the epidemiology and the risk of FMS incidence in several provinces of Iran with a different ethnic population including, Fars, Tehran, Isfahan (Persians), and Mazandaran (Mazanis), Kermanshah (Kurds), and Chaharmahal and Bakhtiari (Lors).
METHODS: This cross-sectional registry-based study was performed on nationwide MS registry of Iran (NMSRI) data collected from 2018 to 2021. This system, registers baseline characteristics, clinical presentations and symptoms, diagnostic and treatments at regional and national levels.
RESULTS: A total of 9200 patients including, 7003 (76.1%) female and 2197 (23.9%) male, were participated. About 19% of patients reported a family history of MS; the order from highest to lowest FMS prevalence was as follows: Fars (26.5%), Chaharmahal and Bakhtiari (21.1%), Tehran (20.5%), Isfahan (20.3%), Mazandaran (18.0%), and Kermanshah (12.5%). Of all FMS cases, 74.7% (1308 cases) were female and 25.3% (442 cases) were male. FMS occurrence was much more common in females than males (P-value = 0.001). Further, the mean age at onset was 30 years among FMS cases. A substantially higher probability of relapsing-remitting MS and secondary-progressive MS was found among FMS cases than sporadic MS (SMS) (P_value = 0.001). There was no significant difference in Expanded Disability Status Scale (EDSS) scores between FMS and SMS. The majority of FMS cases were observed among first-degree relatives, with the highest rate in siblings. There was a significant association between MS risk and positive familial history in both maternal and paternal aunt/uncle (P_value = 0.043 and P_value = 0.019, respectively). Multiple sclerosis occurrence among offspring of females was higher than males (P_value = 0.027).
CONCLUSIONS: In summary, our findings imply a noteworthy upward trend of FMS in Iran, even more than the global prevalence, which suggests a unique Atlas of FMS prevalence in this multi-ethnic population. Despite the highest rate of FMS within Persian and Lor ethnicities, no statistically significant difference was observed among the provinces.
| Medienart: |
E-Artikel |
|---|
| Erscheinungsjahr: |
2022 |
|---|---|
| Erschienen: |
2022 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:22 |
|---|---|
| Enthalten in: |
BMC neurology - 22(2022), 1 vom: 05. März, Seite 76 |
| Sprache: |
Englisch |
|---|
| Beteiligte Personen: |
Salehi, Zahra [VerfasserIn] |
|---|
| Links: |
|---|
| Themen: |
Familial multiple sclerosis |
|---|
| Anmerkungen: |
Date Completed 08.03.2022 Date Revised 18.03.2022 published: Electronic Citation Status MEDLINE |
|---|
| doi: |
10.1186/s12883-022-02609-1 |
|---|
| funding: |
|
|---|---|
| Förderinstitution / Projekttitel: |
|
| PPN (Katalog-ID): |
NLM337790841 |
|---|
| LEADER | 01000naa a22002652 4500 | ||
|---|---|---|---|
| 001 | NLM337790841 | ||
| 003 | DE-627 | ||
| 005 | 20231225235219.0 | ||
| 007 | cr uuu---uuuuu | ||
| 008 | 231225s2022 xx |||||o 00| ||eng c | ||
| 024 | 7 | |a 10.1186/s12883-022-02609-1 |2 doi | |
| 028 | 5 | 2 | |a pubmed24n1125.xml |
| 035 | |a (DE-627)NLM337790841 | ||
| 035 | |a (NLM)35248009 | ||
| 040 | |a DE-627 |b ger |c DE-627 |e rakwb | ||
| 041 | |a eng | ||
| 100 | 1 | |a Salehi, Zahra |e verfasserin |4 aut | |
| 245 | 1 | 0 | |a Epidemiology of familial multiple sclerosis in Iran |b a national registry-based study |
| 264 | 1 | |c 2022 | |
| 336 | |a Text |b txt |2 rdacontent | ||
| 337 | |a ƒaComputermedien |b c |2 rdamedia | ||
| 338 | |a ƒa Online-Ressource |b cr |2 rdacarrier | ||
| 500 | |a Date Completed 08.03.2022 | ||
| 500 | |a Date Revised 18.03.2022 | ||
| 500 | |a published: Electronic | ||
| 500 | |a Citation Status MEDLINE | ||
| 520 | |a © 2022. The Author(s). | ||
| 520 | |a BACKGROUND: Admittedly, little is known about the epidemiological signatures of familial multiple sclerosis (FMS) in different geographical regions of Iran | ||
| 520 | |a OBJECTIVE: To determine the epidemiology and the risk of FMS incidence in several provinces of Iran with a different ethnic population including, Fars, Tehran, Isfahan (Persians), and Mazandaran (Mazanis), Kermanshah (Kurds), and Chaharmahal and Bakhtiari (Lors) | ||
| 520 | |a METHODS: This cross-sectional registry-based study was performed on nationwide MS registry of Iran (NMSRI) data collected from 2018 to 2021. This system, registers baseline characteristics, clinical presentations and symptoms, diagnostic and treatments at regional and national levels | ||
| 520 | |a RESULTS: A total of 9200 patients including, 7003 (76.1%) female and 2197 (23.9%) male, were participated. About 19% of patients reported a family history of MS; the order from highest to lowest FMS prevalence was as follows: Fars (26.5%), Chaharmahal and Bakhtiari (21.1%), Tehran (20.5%), Isfahan (20.3%), Mazandaran (18.0%), and Kermanshah (12.5%). Of all FMS cases, 74.7% (1308 cases) were female and 25.3% (442 cases) were male. FMS occurrence was much more common in females than males (P-value = 0.001). Further, the mean age at onset was 30 years among FMS cases. A substantially higher probability of relapsing-remitting MS and secondary-progressive MS was found among FMS cases than sporadic MS (SMS) (P_value = 0.001). There was no significant difference in Expanded Disability Status Scale (EDSS) scores between FMS and SMS. The majority of FMS cases were observed among first-degree relatives, with the highest rate in siblings. There was a significant association between MS risk and positive familial history in both maternal and paternal aunt/uncle (P_value = 0.043 and P_value = 0.019, respectively). Multiple sclerosis occurrence among offspring of females was higher than males (P_value = 0.027) | ||
| 520 | |a CONCLUSIONS: In summary, our findings imply a noteworthy upward trend of FMS in Iran, even more than the global prevalence, which suggests a unique Atlas of FMS prevalence in this multi-ethnic population. Despite the highest rate of FMS within Persian and Lor ethnicities, no statistically significant difference was observed among the provinces | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a Familial multiple sclerosis | |
| 650 | 4 | |a Iran | |
| 650 | 4 | |a Multiple sclerosis | |
| 650 | 4 | |a Sporadic multiple sclerosis | |
| 700 | 1 | |a Almasi-Hashiani, Amir |e verfasserin |4 aut | |
| 700 | 1 | |a Sahraian, Mohammad Ali |e verfasserin |4 aut | |
| 700 | 1 | |a Ashtari, Fereshteh |e verfasserin |4 aut | |
| 700 | 1 | |a Baghbanian, Seyed Mohammad |e verfasserin |4 aut | |
| 700 | 1 | |a Razazian, Nazanin |e verfasserin |4 aut | |
| 700 | 1 | |a Moghadasi, Abdorreza Naser |e verfasserin |4 aut | |
| 700 | 1 | |a Bayati, Asghar |e verfasserin |4 aut | |
| 700 | 1 | |a Azimi, Amir Reza |e verfasserin |4 aut | |
| 700 | 1 | |a Beladimoghadam, Nahid |e verfasserin |4 aut | |
| 700 | 1 | |a Harirchian, Mohammad Hossein |e verfasserin |4 aut | |
| 700 | 1 | |a Poursadeghfard, Maryam |e verfasserin |4 aut | |
| 700 | 1 | |a Navardi, Samira |e verfasserin |4 aut | |
| 700 | 1 | |a Shirkoohi, Reza |e verfasserin |4 aut | |
| 700 | 1 | |a Heidari, Hora |e verfasserin |4 aut | |
| 700 | 1 | |a Ghaffari, Mehran |e verfasserin |4 aut | |
| 700 | 1 | |a Eskandarieh, Sharareh |e verfasserin |4 aut | |
| 773 | 0 | 8 | |i Enthalten in |t BMC neurology |d 2001 |g 22(2022), 1 vom: 05. März, Seite 76 |w (DE-627)NLM11120092X |x 1471-2377 |7 nnns |
| 773 | 1 | 8 | |g volume:22 |g year:2022 |g number:1 |g day:05 |g month:03 |g pages:76 |
| 856 | 4 | 0 | |u http://dx.doi.org/10.1186/s12883-022-02609-1 |3 Volltext |
| 912 | |a GBV_USEFLAG_A | ||
| 912 | |a GBV_NLM | ||
| 951 | |a AR | ||
| 952 | |d 22 |j 2022 |e 1 |b 05 |c 03 |h 76 | ||